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    v1.0.28
    OpenPayerBilling CodesQualitative or Semiquantitative ImmunoassaysCPT cpt-86635-coccidioides-antibody-immunoassay-blood-csf
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    CPT 86635: Coccidioides Antibody Immunoassay

    CPT code 86635 describes an immunoassay performed by a laboratory analyst to detect antibodies to the fungus Coccidioides in blood or cerebrospinal fluid; this is a laboratory infectious disease serology test commonly performed as a diagnostic immunoassay in clinical laboratories or hospital laboratory settings for patients with suspected coccidioidomycosis, including evaluation of systemic or central nervous system infection.

    For related coverage guidance, see recent payer policy updates: Diagnosis of Idiopathic Environmental Intolerance, Allergen Testing, Allergen Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A patient presents to an outpatient laboratory or hospital clinical laboratory with symptoms of a systemic or pulmonary fungal infection — for example, fever, cough, weight loss, night sweats, arthralgia, or a progressive respiratory illness in a person who lives in or has traveled to endemic areas for Coccidioides (Valley fever). The ordering clinician (infectious disease specialist, pulmonologist, emergency physician, or primary care provider) requests serologic testing to detect IgM and/or IgG antibodies to Coccidioides in serum or cerebrospinal fluid when disseminated disease or meningitis is suspected.

    The typical workflow: the clinician orders the test; a phlebotomist collects blood (serum) or a provider collects cerebrospinal fluid during lumbar puncture; the specimen is transported to the laboratory with appropriate labeling and requisition. A laboratory technologist or immunology specialist performs the immunoassay (enzyme immunoassay or other FDA-cleared method) and interprets results. Results are returned to the ordering provider, often with reflex testing recommendations (e.g., complement fixation, culture, or repeat serology) documented in the lab report. Common sites of service include outpatient laboratories, hospital inpatient laboratories, emergency departments, and ambulatory clinics where phlebotomy is performed.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    86635Antibody; Coccidioides (immunoassay)Primary immunoassay used to detect antibodies to Coccidioides in serum or CSF.
    86664Antibody; Histoplasma capsulatum (immunoassay)Other fungal serology that may be ordered in the differential diagnosis of endemic mycoses.
    86661Antibody; Blastomyces dermatitidis (immunoassay)Alternative fungal serology for differential diagnosis of systemic/mycotic infections.
    87070Culture, bacterial; any source, other than blood, aerobic with isolation and presumptive identification of isolatesMay be performed when attempting to culture respiratory or other specimens for fungal pathogens as part of the workup.
    87077Culture, fungal, any source, with isolation and presumptive identificationFungal culture that can be ordered alongside serology when direct organism detection is indicated.
    36556Collection of blood specimen from a central venous catheterProcedure code relevant when blood for serology is drawn from an indwelling catheter rather than peripheral venipuncture.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    208C00000XColon & Rectal Surgery PhysicianA colon and rectal surgeon is trained to diagnose and treat various diseases of the intestinal tract, colon, rectum, anal canal and perianal area by m…
    261QA0900XAmputee Clinic/CenterAn entity, facility, or distinct part of a facility providing counseling, fitting, custom design, prescriptive, and training services related to conge…
    2080H0002XPediatric Hospice and Palliative Medicine PhysicianA pediatrician with special knowledge and skills to prevent and relieve the suffering experienced by patients with life-limiting illnesses. This speci…
    207ZD0900XDermatopathology (Pathology) PhysicianA dermatopathologist is an expert in diagnosing and monitoring diseases of the skin including infectious, immunologic, degenerative, and neoplastic di…

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B38.0Acute pulmonary coccidioidomycosis
    B38.1Chronic pulmonary coccidioidomycosis
    B38.2Pulmonary coccidioidomycosis, unspecified
    B38.3Cutaneous coccidioidomycosis
    B38.4Coccidioidomycosis meningitis
    B38.7Disseminated coccidioidomycosis
    B95.3Streptococcus pneumoniae as the cause of diseases classified elsewhere
    B96.89Other specified bacterial agents as the cause of diseases classified elsewhere
    B99.9Unspecified infectious disease

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Allergy/Clinical Immunology1 / 3

    9 rows

    PolicyPayerEffective Date
    Diagnosis of Idiopathic Environmental IntoleranceOscar Health2026-10-01
    Allergen Testingblue cross blue shield - louisiana2026-09-15
    Allergen TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Hereditary Angioedema - EkterlyCigna2026-08-15
    Omalizumab products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab Products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab ProductsPremera Bluecross2026-08-01
    Allergy Testinguniverahealthcare2026-07-16
    Omalizumab (Xolair) and related biologics coverageMass General Brigham Health Plan2026-07-01

    Related Codes

    86803-QUALITATIVE-OR-SEMIQUANTITATIVE-IMMUNOASSAYS-HEPATITIS-C

    CPT 86803: Hepatitis C Antibody Immunoassay in Serum

    CPT-86000-FEBRILE-AGGLUTININS-SEROLOGIC-TEST

    CPT 86000: Febrile Agglutinins (Serologic Agglutination) Test

    CPT-86001-ALLERGEN-SPECIFIC-IGG-LABORATORY-TEST

    CPT 86001: Allergen-Specific IgG Assay, Technical Component

    CPT-86003-ALLERGEN-SPECIFIC-IGE-ASSAY-TECHNICAL

    CPT 86003: Allergen‑Specific IgE Assay Using Crude Allergen Extract

    CPT-86005-MULTI-ALLERGEN-IGE-SCREENING-QUALITATIVE

    CPT 86005: Multi-Allergen Allergen-Specific IgE Screening

    CPT-86008-ALLERGEN-COMPONENT-SPECIFIC-IGE-ASSAY

    CPT 86008: Allergen Component–Specific IgE Assay

    CPT-86015-ANTI-ACTIN-SMOOTH-MUSCLE-ANTIBODY-ASMA

    CPT 86015: Actin (Smooth Muscle) Antibody (ASMA) Immunoassay

    CPT-86021-LEUKOCYTE-ANTIBODY-IDENTIFICATION-LAB-TECHNICAL

    CPT 86021: Leukocyte Antibody Identification Laboratory Test

    CPT-86022-PLATELET-ANTIBODY-IDENTIFICATION-TECHNICAL-TEST

    CPT 86022: Platelet Antibody Detection and Identification

    CPT-86023-PLATELET-ASSOCIATED-IMMUNOGLOBULIN-DETECTION

    CPT 86023: Platelet-Associated Immunoglobulin Assay

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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