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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-84460-alt-serum-alanine-aminotransferase-test
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    CPT 84460: Alanine Aminotransferase (ALT) Quantitative

    Commercial payers pay $10 on average nationally for this procedure.

    CPT code 84460 reports a laboratory quantitative alanine aminotransferase (ALT/SGPT) test performed on serum or plasma using automated chemistry analyzers to assess liver injury or dysfunction; service type: clinical laboratory chemistry test; typical site of service: clinical laboratory or hospital laboratory (outpatient or inpatient collection with laboratory processing).

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing, Bone Turnover Markers Testing.

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    National Reimbursement Benchmarks

    For CPT 84460, national commercial pricing centers on BUCA’s average commercial rate of $9.9, with individual payers showing distinct centering and spread. Blue Cross Blue Shield posts the highest mean at $12.9 and a wide upper tail, while Aetna and Cigna cluster lower with means of $7.3 and $6.1 respectively. UnitedHealth Group’s mean of $4.7 sits below BUCA, indicating that BUCA’s commercial average is above several major national payers but below Blue Cross Blue Shield’s mean.

    Comparing dispersion (P75 minus P25) highlights variation in market consistency: Blue Cross Blue Shield’s spread is $7.6, UnitedHealth Group’s is $3.0, Cigna’s is $3.2, Aetna’s is $3.4, and BUCA’s interquartile spread is $5.8. Blue Cross Blue Shield therefore exhibits the widest IQR-driven dispersion, while UnitedHealth Group is the tightest, suggesting the greatest and least variability in mid-market commercial rates respectively.

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    National Payer Mean Reimbursement Rates

    State Reimbursement Rates

    State: Alaska1 / 51

    Rate by payer

    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old patient presents to a primary care clinic with fatigue and mild right upper quadrant discomfort. The clinician orders routine liver chemistries to evaluate possible hepatocellular injury given a history of chronic alcohol use and prior positive hepatitis C antibody. A venous blood sample is collected in the outpatient phlebotomy area and sent to the hospital clinical laboratory. The lab technologist performs a quantitative serum alanine aminotransferase measurement using automated chemistry analyzers. Results are reported electronically to the ordering provider and entered into the electronic health record for interpretation alongside other liver function tests.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    84450Aspartate aminotransferase (AST) (SGOT)Often ordered concurrently with 84460 to compare AST and ALT patterns in liver injury.
    80076Hepatic function panelIncludes multiple hepatic tests; 84460 may be part of or replaced by this panel depending on order set.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    291U00000XClinical Medical Laboratory(1) A clinical laboratory is a facility for the biological, microbiological, serological, chemical, immunohematological, hematological, biophysical, c…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    282NR1301XRural Acute Care HospitalHospitals · General Acute Care Hospital
    333300000XEmergency Response System CompaniesA supplier of a personal emergency response system (PERS), which is an electronic device that enables a patient to receive emergency assistance when n…
    364SN0800XNeuroscience Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    385HR2050XRespite Care CampA camping facility that provides specialized respite care to individuals requiring enhanced services to enable them to remain in the community, (e.g.,…
    207N00000XDermatology PhysicianA dermatologist is trained to diagnose and treat pediatric and adult patients with benign and malignant disorders of the skin, mouth, external genital…

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Diabetes Mellitus Testing — Coverage CriteriaOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01
    Thyroid Disease Testingblue cross blue shield - louisiana2026-09-15
    Thyroid Disease TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Parathyroid Hormone, Phosphorous, Calcium and Magnesium TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Testosterone laboratory testing and managementPremera Bluecross2026-09-04

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    82947Glucose; quantitative, blood (except reagent strip)Frequently ordered alongside liver tests for metabolic assessment during the visit.
    83036Hemoglobin; glycosylated (A1C)Ordered in patients with risk factors for metabolic liver disease; may be part of comprehensive evaluation.