Summary & Overview
CPT 82030: Quantitative cAMP Assay on Plasma or Urine
CPT code 82030 denotes a quantitative cyclic adenosine monophosphate (cAMP) assay performed on plasma or urine. The assay aids in differentiating causes of altered calcium and vitamin D metabolism, notably in the workup of suspected hyperparathyroidism and vitamin D deficiency. As a specialized biochemical laboratory test, it is ordered by clinicians managing disorders of mineral metabolism, endocrinology teams, and inpatient services when biochemical clarification is required.
Key payers commonly involved in coverage for this service include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find clinical context for when the test is used, typical sites of service, and the operational implications for laboratories and ordering clinicians. The publication also covers billing considerations and common modifiers used with laboratory services (general overview), payment benchmarks and variability across major national payers, and policy developments that affect laboratory reimbursement and medical necessity review for specialized endocrine assays.
This summary targets laboratory managers, billing professionals, clinicians in endocrinology and primary care, and policy analysts seeking a concise national view of CPT code 82030, its clinical role, and payer coverage landscape.
Billing Code Overview
CPT code 82030 describes a quantitative cyclic adenosine, 5–monophosphate (cAMP) assay performed on plasma or urine. The test measures levels of cyclic adenosine monophosphate and is used in the differential diagnosis of hyperparathyroidism and vitamin D deficiency.
Service Type: Laboratory diagnostic test, quantitative biochemical assay
Typical Site of Service: Clinical laboratory or hospital laboratory; outpatient specimen collection (phlebotomy) or urine collection site
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Clinical & Coding Specifications
Clinical Context
A 52-year-old outpatient referred by an endocrinologist for biochemical evaluation of suspected primary hyperparathyroidism after routine labs show hypercalcemia and an elevated parathyroid hormone. The clinician orders a quantitative cyclic adenosine 5′-monophosphate (cAMP) assay on urine (or plasma if urine unavailable) to help differentiate parathyroid hormone–related hypercalcemia from other causes such as vitamin D deficiency or renal tubular disorders. The patient presents to the outpatient laboratory fasting, with a timed urine collection started in the morning and processed per laboratory protocol. The lab analyst performs 82030 (quantitative cAMP) with appropriate specimen handling, analytic run, and reporting of numerical results. Results are routed to the ordering endocrinologist who integrates them with serum calcium, serum PTH, 25-hydroxyvitamin D, and renal function to support diagnosis and management planning. Typical sites of service include outpatient hospital laboratories, independent reference laboratories, and hospital-based clinical laboratories supporting ambulatory care and specialty clinics.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | Unspecified or not applicable | Rarely used; indicates no specific modifier applies when billing system requires a placeholder |