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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-84060-total-acid-phosphatase-serum-enzyme-assay
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    CPT 84060: Total Acid Phosphatase Measurement

    CPT code 84060 describes a laboratory assay measuring total acid phosphatase, typically performed on a serum specimen to evaluate enzyme activity arising from the liver, bone, spleen, kidneys, and prostate (in males); this is a clinical chemistry service commonly provided in clinical laboratories and hospital laboratory departments for diagnostic or monitoring purposes.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Bone Turnover Markers Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male with a history of prostate cancer presents for routine oncologic surveillance. His oncologist orders a serum total acid phosphatase to evaluate for potential prostate disease activity and to assess for other causes of elevated acid phosphatase such as hepatic or bone pathology. A phlebotomist draws a serum specimen in an outpatient laboratory or hospital outpatient phlebotomy station. The specimen is processed by the clinical laboratory; the lab analyst performs a quantitative enzymatic assay to measure total acid phosphatase activity. Results are reported to the ordering provider and placed in the electronic medical record for comparison with prior values. Typical sites of service include hospital outpatient laboratory, independent clinical laboratory, ambulatory surgery center laboratory, and physician office-based laboratory services.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    84153Prostate specific antigen (PSA); totalCommonly ordered alongside acid phosphatase for prostate cancer screening and surveillance
    80053Comprehensive metabolic panelOrdered to assess liver and renal function when interpreting elevated acid phosphatase levels
    82040Albumin; totalFrequently included in chemistry panels to evaluate hepatic synthetic function when acid phosphatase is abnormal
    84443Thyroid stimulating hormone (TSH)Evaluated in broader diagnostic workups affecting metabolic status that may influence enzyme levels
    88305Surgical pathology, intermediate levelIf prostate biopsy or surgical tissue is obtained to correlate with biochemical markers, pathology coding applies

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RP1001XPulmonary Disease PhysicianAn internist who treats diseases of the lungs and airways. The pulmonologist diagnoses and treats cancer, pneumonia, pleurisy, asthma, occupational an…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    3336S0011XSpecialty PharmacyA pharmacy that dispenses generally low volume and high cost medicinal preparations to patients who are undergoing intensive therapies for illnesses t…
    207XS0106XOrthopaedic Hand Surgery PhysicianAn orthopaedic surgeon trained in the investigation, preservation and restoration by medical, surgical and rehabilitative means of all structures of t…
    2080I0007XPediatric Clinical & Laboratory Immunology PhysicianA pediatrician who specializes in clinical and laboratory immunology disease management.
    246W00000XCardiology TechnicianAn individual who has knowledge of specific techniques, instruments, and equipment required in performing specific cardiovascular/peripheral vascular …
    246Y00000XHealth Information Specialist/TechnologistAn individual with a high school diploma, on-the-job experience and coding education from seminars or college classes who passes a national certificat…

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    5 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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