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    v1.0.30
    OpenPayerBilling CodesTier 2 Molecular Pathology ProceduresCPT cpt-81407-tier-2-level-8-molecular-pathology-technical-test
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    CPT 81407: Technical Molecular Pathology Lab Test

    Commercial payers pay $900 on average nationally for this procedure.

    CPT code 81407 describes a Tier 2, Level 8 molecular pathology service in which a laboratory analyst performs the technical component of a specified genetic analysis; the service type is technical laboratory testing and the typical site of service is a clinical or reference laboratory where molecular diagnostic assays are completed.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    National Reimbursement Benchmarks

    National commercial reimbursement for CPT 81407 clusters around the BUCA average commercial rate of $900.20, with individual payers showing distinct central tendencies: Blue Cross Blue Shield centers near a higher median ($896.90) and Cigna and Aetna show elevated means driven by higher maximums. UnitedHealth Group’s median of $507.80 sits well below BUCA and most peers, indicating lower typical payments from that carrier.

    Dispersion (P75 minus P25) highlights variability: Blue Cross Blue Shield has a range of $309.10 ($1,086.60 - $747.50) and Cigna shows the widest interquartile spread at $781.70 ($1,234.70 - $453.00). UnitedHealth Group is among the tightest with a range of $491.00 ($846.30 - $355.40), while Aetna’s interquartile range is $341.50 ($846.30 - $480.00). These differences point to meaningful payer-by-payer volatility in commercial reimbursement levels.

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    National Payer Mean Reimbursement Rates

    State Reimbursement Rates

    State: Alaska1 / 51

    Rate by payer

    Clinical & Coding Specifications

    Clinical Context

    A 32-year-old pregnant woman presents for noninvasive prenatal screening after a routine obstetric visit flagged advanced maternal age and a family history of chromosomal abnormality. Her obstetrician documents counseling and orders a plasma-based cell-free DNA assay targeting common fetal aneuploidies and specific genetic analyses. The specimen is collected at an outpatient obstetrics clinic or collection center and shipped to a reference molecular pathology laboratory. In the laboratory, a lab analyst performs the technical procedures for one of the Tier 2, Level 8 molecular pathology analyses represented by 81407 (instrument runs, library preparation, sequencing or other analytic steps) to generate raw data used by the reporting algorithm. The laboratory information system records the specimen processing steps, links the technical component to the performing pathology or molecular lab taxonomy, and forwards analytic results to the laboratory director for interpretation and reporting. Typical sites of service include an independent clinical molecular pathology laboratory, hospital-based pathology laboratory, or a reference diagnostic laboratory. Common clinical workflow elements include specimen accessioning, DNA extraction, library preparation or targeted analysis, sequencing or assay run, quality control, and handoff to the professional component for interpretation and test report issuance.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81507Fetal aneuploidy (trisomy 21, 18, and 13) DNA sequence analysis of selected regions using maternal plasma, algorithm reported as a risk score for each trisomy

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207ZP0007X
    207L00000X
    207V00000X
    207R00000X
    207Q00000X
    261QG0250X
    173F00000X
    152WL0500X

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 2

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-81400-MOLECULAR-PATHOLOGY-TECHNICAL-LAB-PROCEDURE

    CPT 81400: Molecular Pathology Tier 2, Level 1 Technical Test

    CPT-81401-MOLECULAR-PATHOLOGY-TECHNICAL-LAB-ANALYSIS

    CPT 81401: Tier 2, Level 2 Molecular Pathology Technical Test

    CPT-81402-MOLECULAR-PATHOLOGY-LEVEL-3-TECHNICAL-TEST

    CPT 81402: Molecular Pathology Tier 2 Level 3 Technical Test

    CPT-81403-TIER-2-LEVEL-4-MOLECULAR-PATHOLOGY-TECHNICAL

    CPT 81403: Molecular Pathology Technical Component, Tier 2 Level 4

    CPT-81404-TIER-2-MOLECULAR-PATHOLOGY-TECHNICAL-COMPONENT

    CPT 81404: Molecular Pathology Technical Laboratory Procedure

    CPT-81405-MOLECULAR-PATHOLOGY-TECHNICAL-LAB-TESTING

    CPT 81405: Tier 2 Level 6 Molecular Pathology Lab Test

    CPT-81406-MOLECULAR-PATHOLOGY-TECHNICAL-LAB-ANALYSIS

    CPT 81406: Molecular Pathology Tier 2, Level 7 Technical Component

    CPT-81408-MOLECULAR-PATHOLOGY-TECHNICAL-TIER-2-LEVEL-9

    CPT 81408: Tier 2 Molecular Pathology Technical Laboratory Analysis

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
    Published by

    Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

    81507 is a related analytic and reporting code representing the algorithmic interpretation and risk scoring that may accompany the technical data generated under 81407; results from 81407 technical processing feed into 81507 reporting.