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    v1.0.28
    OpenPayerBilling CodesDefinitive Drug Testing ProceduresCPT cpt-80359-methylenedioxyamphetamines-assay
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    CPT 80359: Detection of Methylenedioxyamphetamines

    CPT code 80359 describes a laboratory test in which the lab analyst measures the amount of or detects the presence of methylenedioxyamphetamines in a patient specimen, a toxicology drug detection service typically performed in a clinical laboratory or pathology setting using validated analytical methods for forensic, clinical, or monitoring purposes.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient scenario involves an adult who presents to an emergency department, urgent care, inpatient unit, or outpatient clinic with altered mental status, suspected recreational designer drug use, acute agitation, unexplained tachycardia or hypertension, or possible drug-facilitated assault. A clinician orders toxicology testing to detect methylenedioxyamphetamines (MDMA, MDA, MDEA) in a blood or urine specimen. The specimen is collected, labeled, and sent to the hospital clinical laboratory or a reference laboratory. A laboratory analyst performs an immunoassay screen or confirmatory analytical method (such as GC-MS or LC-MS/MS) specific for methylenedioxyamphetamines and documents the presence or quantitative amount. Results are reported back to the ordering clinician to inform acute management, disposition, forensic reporting, or occupational health decisions.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80307Drug test, presumptive, any number of drug classes, any number of devices or procedures, non-quantitative; multiple drug classesOften used as an initial immunoassay screen for amphetamines including methylenedioxy derivatives prior to specific confirmatory testing.
    80305Drug test, presumptive, any number of drug classes, any number of devices or procedures, qualitative; 1-2 drug classesMay be used for point-of-care or limited presumptive testing when amphetamine class is one of the classes tested.
    80374Mass spectrometry, qualitative or quantitative, drug confirmation (eg, GC-MS, LC-MS/MS), per specimenCommonly used for confirmatory testing to identify and quantify methylenedioxyamphetamines after a positive screen.
    86003Antibody, microorganism specific; quantitative or semi-quantitative, eachNot typically used for drugs of abuse; included only when immunoassay methods using antibodies are documented.
    99000Handling and/or conveyance of specimenNot an official CPT code for this context; Data not available in the input.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    193400000XSingle Specialty GroupA business group of one or more individual practitioners, all of who practice with the same area of specialization.
    2080P0203XPediatric Critical Care Medicine PhysicianA pediatrician expert in advanced life support for children from the term or near-term neonate to the adolescent. This competence extends to the criti…
    2472E0500XEEG TechnicianTechnologists, Technicians & Other Technical Service Providers · Technician, Other
    251X00000XSupports Brokerage AgencyA provider of service/function that assists participating individuals to make informed decisions about what will work best for them is consistent with…
    261QC1500XCommunity Health Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    207ZP0101XAnatomic Pathology PhysicianA pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis and treatment through knowledge gained by the labora…

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    F10.129Alcohol abuse with intoxication, unspecified
    F10.920Alcohol use, unspecified with intoxication, uncomplicated
    F11.10Opioid abuse, uncomplicated
    F11.151Opioid abuse with opioid-induced psychotic disorder with hallucinations
    F11.20Opioid dependence, uncomplicated
    F11.21Opioid dependence, in remission
    F12.10Cannabis abuse, uncomplicated
    F12.151Cannabis abuse with psychotic disorder with hallucinations
    F12.21Cannabis dependence, in remission
    F13.10Sedative, hypnotic or anxiolytic abuse, uncomplicated

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    CPT-80320-ALCOHOL-DETECTION-IN-SPECIMEN

    CPT 80320: Alcohol Detection and Quantification

    CPT-80321-ALCOHOL-BIOMARKER-ASSAY

    CPT 80321: Alcohol Biomarker Assay, One or Two Compounds

    CPT-80322-ALCOHOL-BIOMARKER-PANEL-MULTI-ANALYTE

    CPT 80322: Alcohol Biomarker Panel, Three or More Compounds

    CPT-80323-ALKALOID-DRUG-LEVEL-ANALYSIS

    CPT 80323: Alkaloid Drug Identification and Quantitation

    CPT-80324-AMPHETAMINE-DRUG-TESTING-LAB-ASSAY

    CPT 80324: Amphetamine Detection and Quantification

    CPT-80325-AMPHETAMINES-DETECTION-AND-QUANTIFICATION

    CPT 80325: Detection of Three or Four Amphetamines

    CPT-80326-AMPHETAMINES-PANEL-5-OR-MORE

    CPT 80326: Detection/Quantification of Five or More Amphetamines

    CPT-80334-SEROTONERGIC-ANTIDEPRESSANT-PANEL

    CPT 80334: Detection of Six or More Serotonergic Antidepressants

    CPT-80335-TRICYCLIC-ANTIDEPRESSANT-ASSAY

    CPT 80335: Tricyclic and Cyclical Antidepressant Assay

    CPT-80344-MULTI-ANTIPSYCHOTIC-PANEL-SEVEN-PLUS-DRUGS

    CPT 80344: Multiplex Antipsychotic Drug Detection (7+ agents)

    Showing 1–10 of 24

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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