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    v1.0.30
    OpenPayerBilling CodesOrgan or Disease Oriented PanelsCPT cpt-80081-obstetric-panel-initial-prenatal-testing
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    CPT 80081: Obstetric Screening Panel for Prenatal Care

    CPT code 80081 describes an obstetric screening panel performed by a laboratory analyst that includes a complete blood count with differential, hepatitis B surface antigen, a combined HIV-1 antigen/antibody test for HIV-1 and HIV-2, rubella antibody, a qualitative nontreponemal syphilis test, red blood cell antibody screen, ABO blood typing, and Rh typing; the service is a prenatal laboratory panel typically provided in an outpatient laboratory or hospital outpatient setting as part of prenatal care.

    For related coverage guidance, see recent payer policy updates: Long-Acting Injectable Antiretroviral Agents for HIV, B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays.

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    Clinical & Coding Specifications

    Clinical Context

    A pregnant patient at an initial prenatal visit has a comprehensive obstetric laboratory panel ordered to establish baseline maternal and fetal risk status. The obstetric panel is performed by the laboratory and includes a complete blood count with differential to assess anemia and infection, hepatitis B surface antigen to detect active hepatitis B infection, a single-result combined antigen/antibody test for HIV-1 and HIV-2 to identify maternal HIV infection, rubella IgG antibody to determine immunity, a qualitative nontreponemal syphilis test (e.g., RPR or VDRL) for syphilis screening, a red blood cell antibody screen to detect clinically significant alloantibodies, and ABO and Rh typing (including Rh(D)) to determine blood group and alloimmunization risk. Typical workflow: physician or midwife documents pregnancy and indications and places electronic lab orders; the patient presents to an outpatient clinic or laboratory phlebotomy unit; a phlebotomist collects specimens with appropriate tubes; the laboratory performs the specified assays, documents results in the electronic medical record, and issues critical value notifications if indicated. Results guide interventions such as hepatitis B vaccination counseling, HIV management and prophylaxis, treatment of syphilis, Rh(D) immune globulin administration planning, and referral to specialty care if infections or significant antibodies are identified.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipunctureCommonly performed immediately prior to the obstetric panel to obtain required specimens.
    84702Hepatitis B surface antigen (HBsAg), qualitative or quantitativeComponent test within the obstetric panel to detect active hepatitis B infection; may be billed separately if panel components billed individually.
    86701HIV-1 antigen(s), with HIV-1 and HIV-2 antibody(s), single resultRepresents the combined antigen/antibody HIV test required in the obstetric panel; may be reported separately in some workflows.
    86762Rubella antibody; IgGThe rubella IgG immunity test included in the obstetric panel; may be ordered individually for specific evaluation.
    86592Syphilis screen, qualitative (e.g., RPR, VDRL)The qualitative nontreponemal syphilis test required in the obstetric panel; may be billed separately if performed outside the panel.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208D00000X
    207L00000X
    207K00000X
    208M00000X
    2080P0208X
    163WH1000X
    2086S0127X
    111NN1001X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    O09.00Supervision of pregnancy with history of infertility, unspecified trimester
    O09.90Supervision of high risk pregnancy, unspecified, unspecified trimester
    O14.00Mild to moderate pre-eclampsia, unspecified trimester
    O14.10Severe pre-eclampsia, unspecified trimester
    O20.0Threatened abortion
    O26.841Uterine size-date discrepancy, first trimester
    O26.842Uterine size-date discrepancy, second trimester
    O26.843Uterine size-date discrepancy, third trimester
    O82Encounter for cesarean delivery without indication
    Z03.71Encounter for suspected problem with amniotic cavity and membrane ruled out

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    CPT-80047-BASIC-METABOLIC-PANEL-BMP

    CPT 80047: Basic Metabolic Panel (BMP)

    CPT-80048-BASIC-METABOLIC-PANEL-BMP

    CPT 80048: Basic Metabolic Panel (BMP)

    CPT-80050-GENERAL-HEALTH-PANEL-SCREENING-LAB

    CPT 80050: General Health Panel Screening

    CPT-80051-ELECTROLYTE-PANEL-NA-CL-K-CLO-CO2

    CPT 80051: Electrolyte Panel (Na, K, Cl, CO2)

    CPT-80053-COMPREHENSIVE-METABOLIC-PANEL-CMP

    CPT 80053: Comprehensive Metabolic Panel (CMP)

    CPT-80055-OBSTETRIC-PANEL-PRENATAL-LAB-TESTING

    CPT 80055: Obstetric Laboratory Panel

    CPT-80061-LIPID-PANEL-CHOLESTEROL-TRIGLYCERIDES

    CPT 80061: Lipid Panel (Cholesterol and Triglycerides)

    CPT-80069-RENAL-FUNCTION-PANEL-LAB-TEST

    CPT 80069: Renal Function Panel, Blood

    CPT-80074-ACUTE-HEPATITIS-PANEL-SEROLOGY

    CPT 80074: Acute Hepatitis Serology Panel

    CPT-80076-HEPATIC-FUNCTION-PANEL-LIVER-CHEMISTRY

    CPT 80076: Hepatic Function Panel (Liver Chemistry Tests)

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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