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    v1.0.30
    OpenPayerBilling CodesOrgan or Disease Oriented PanelsCPT cpt-80076-hepatic-function-panel-liver-chemistry
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    CPT 80076: Hepatic Function Panel (Liver Chemistry Tests)

    CPT code 80076 describes a hepatic function panel performed by a laboratory analyst that measures blood levels of total protein, albumin, alkaline phosphatase, bilirubin (total and direct), and liver enzymes; service type: clinical laboratory chemistry panel; typical site of service: clinical laboratory or hospital laboratory draw station.

    For related coverage guidance, see recent payer policy updates: Long-Acting Injectable Antiretroviral Agents for HIV, B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays.

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old outpatient with a history of chronic alcohol use and intermittent right upper quadrant pain presents to the primary care clinic for evaluation of fatigue and jaundice. The clinician orders a hepatic function panel to assess liver synthetic function and cholestasis. A phlebotomist obtains a venous blood specimen at the clinic lab; the specimen is transported to the laboratory where the lab analyst performs the hepatic function panel measuring total protein, albumin, alkaline phosphatase, total and direct bilirubin, and liver enzymes (AST, ALT). Results are reported to the ordering provider electronically; abnormal values prompt further workup such as hepatitis serologies, abdominal ultrasound, or referral to hepatology. Typical sites of service include outpatient clinics, hospital outpatient laboratories, and ambulatory surgery centers where routine preoperative or diagnostic liver testing is required.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80048Basic metabolic panel (Calcium, total)Often ordered alongside hepatic panels to assess metabolic status and electrolytes in patients with liver disease.
    82565Creatine kinase, totalMay be included in broader lab workups when muscle injury or systemic disease is considered; occasionally ordered with hepatic testing.
    84460Assay of liver enzyme, alanine aminotransferase (ALT)Individual component of a hepatic panel; may be ordered separately if targeted assessment is needed.
    84450Assay of aspartate aminotransferase (AST)Individual component of a hepatic panel; used when monitoring specific enzyme trends.
    80053Comprehensive metabolic panelFrequently ordered instead of or in addition to a hepatic function panel for broader metabolic and liver assessment.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RG0300X
    207L00000X
    207RH0000X
    3336C0003X
    163WC1500X
    261QP0904X
    207ZP0007X
    261QE0800X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    B18.2Chronic viral hepatitis C
    B19.20Unspecified viral hepatitis C without hepatic coma
    C22.0Liver cell carcinoma
    C22.9Malignant neoplasm of liver, not specified as primary or secondary
    D51.0Vitamin B12 deficiency anemia due to intrinsic factor deficiency
    E10.9Type 1 diabetes mellitus without complications
    E11.69Type 2 diabetes mellitus with other specified complication
    E78.5Hyperlipidemia, unspecified
    E83.49Other disorders of magnesium metabolism
    I85.00Esophageal varices without bleeding

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    CPT-80047-BASIC-METABOLIC-PANEL-BMP

    CPT 80047: Basic Metabolic Panel (BMP)

    CPT-80048-BASIC-METABOLIC-PANEL-BMP

    CPT 80048: Basic Metabolic Panel (BMP)

    CPT-80050-GENERAL-HEALTH-PANEL-SCREENING-LAB

    CPT 80050: General Health Panel Screening

    CPT-80051-ELECTROLYTE-PANEL-NA-CL-K-CLO-CO2

    CPT 80051: Electrolyte Panel (Na, K, Cl, CO2)

    CPT-80053-COMPREHENSIVE-METABOLIC-PANEL-CMP

    CPT 80053: Comprehensive Metabolic Panel (CMP)

    CPT-80055-OBSTETRIC-PANEL-PRENATAL-LAB-TESTING

    CPT 80055: Obstetric Laboratory Panel

    CPT-80061-LIPID-PANEL-CHOLESTEROL-TRIGLYCERIDES

    CPT 80061: Lipid Panel (Cholesterol and Triglycerides)

    CPT-80069-RENAL-FUNCTION-PANEL-LAB-TEST

    CPT 80069: Renal Function Panel, Blood

    CPT-80074-ACUTE-HEPATITIS-PANEL-SEROLOGY

    CPT 80074: Acute Hepatitis Serology Panel

    CPT-80081-OBSTETRIC-PANEL-INITIAL-PRENATAL-TESTING

    CPT 80081: Obstetric Screening Panel for Prenatal Care

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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