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    v1.0.30
    OpenPayerBilling CodesOrgan or Disease Oriented PanelsCPT cpt-80074-acute-hepatitis-panel-serology
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    CPT 80074: Acute Hepatitis Serology Panel

    CPT code 80074 describes an acute hepatitis panel performed by a laboratory analyst that includes testing for hepatitis A IgM antibody, hepatitis B core IgM antibody, hepatitis B surface antigen, and hepatitis C antibody; the service is a clinical laboratory serology panel typically provided in hospital laboratories, outpatient clinical laboratories, and reference laboratory settings for evaluation of suspected acute viral hepatitis.

    For related coverage guidance, see recent payer policy updates: Long-Acting Injectable Antiretroviral Agents for HIV, B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays.

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    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old outpatient with acute onset jaundice, right upper-quadrant pain, dark urine, and recent travel to an area with viral hepatitis exposure presents to an urgent care clinic. The clinician orders an acute hepatitis panel to evaluate for recent infection. A phlebotomy technician draws blood; the specimen is sent to the clinical laboratory. The lab analyst performs serologic testing that must include hepatitis A IgM antibody, hepatitis B core IgM antibody, hepatitis B surface antigen, and hepatitis C antibody as a bundled panel. Results are reviewed by the laboratory director and released to the ordering clinician; positive acute markers prompt immediate clinician notification for public health reporting and patient counseling. Typical sites of service include hospital outpatient laboratories, independent reference laboratories, urgent care centers, and emergency departments where acute viral hepatitis is in the differential diagnosis.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipunctureVenipuncture is commonly performed immediately prior to sending specimens for the acute hepatitis panel.
    80053Comprehensive metabolic panel (CMP)Ordered alongside the hepatitis panel to assess liver function and metabolic status during acute evaluation.
    82728Hepatitis B surface antibody; quantitationPerformed when immune status or response to vaccination needs evaluation after initial hepatitis B surface antigen testing.
    87340Hepatitis C antibody, EIA; screeningAlternative/supplemental hepatitis C antibody testing methodology that may be used in some labs.
    86709Hepatitis A antibody, IgMIndividual component test that is part of or used to verify the acute hepatitis panel results.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    2080P0208X
    207RP1001X
    163W00000X
    311500000X
    305S00000X
    1835P0018X
    229N00000X

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    CPT-80047-BASIC-METABOLIC-PANEL-BMP

    CPT 80047: Basic Metabolic Panel (BMP)

    CPT-80048-BASIC-METABOLIC-PANEL-BMP

    CPT 80048: Basic Metabolic Panel (BMP)

    CPT-80050-GENERAL-HEALTH-PANEL-SCREENING-LAB

    CPT 80050: General Health Panel Screening

    CPT-80051-ELECTROLYTE-PANEL-NA-CL-K-CLO-CO2

    CPT 80051: Electrolyte Panel (Na, K, Cl, CO2)

    CPT-80053-COMPREHENSIVE-METABOLIC-PANEL-CMP

    CPT 80053: Comprehensive Metabolic Panel (CMP)

    CPT-80055-OBSTETRIC-PANEL-PRENATAL-LAB-TESTING

    CPT 80055: Obstetric Laboratory Panel

    CPT-80061-LIPID-PANEL-CHOLESTEROL-TRIGLYCERIDES

    CPT 80061: Lipid Panel (Cholesterol and Triglycerides)

    CPT-80069-RENAL-FUNCTION-PANEL-LAB-TEST

    CPT 80069: Renal Function Panel, Blood

    CPT-80076-HEPATIC-FUNCTION-PANEL-LIVER-CHEMISTRY

    CPT 80076: Hepatic Function Panel (Liver Chemistry Tests)

    CPT-80081-OBSTETRIC-PANEL-INITIAL-PRENATAL-TESTING

    CPT 80081: Obstetric Screening Panel for Prenatal Care

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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