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    v1.0.30
    OpenPayerBilling CodesTherapeutic Nuclear Medicine ProceduresCPT cpt-79999-radiopharmaceutical-therapy-unlisted-procedure
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    CPT 79999: Radiopharmaceutical Therapy, Unlisted Procedure

    CPT code 79999 is an unlisted procedure code used to report a radiopharmaceutical therapy procedure that does not have a specific CPT code; it represents miscellaneous or novel therapeutic radiopharmaceutical services typically performed by nuclear medicine or radiation oncology teams as an interventional treatment and is usually provided in an outpatient infusion or procedural setting such as a hospital outpatient department, ambulatory surgery center, or specialized infusion center.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

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    • Billing CodesCPT, HCPCS, DRG & more
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    Clinical & Coding Specifications

    Clinical Context

    A patient with an uncommon malignancy or a rare indication is referred for radiopharmaceutical therapy that does not have a published, discrete CPT code. Typical patients are adults with metastatic neuroendocrine tumors, refractory thyroid cancer, oligometastatic bone disease, or experimental/compassionate-use indications receiving an institutional radiopharmaceutical that lacks a specific code. The clinical workflow begins with multidisciplinary review (medical oncology, nuclear medicine, and radiation oncology), informed consent, and eligibility confirmation (performance status, organ function, recent imaging). Pre-procedure preparation includes medication review, hydration, and thyroid blockade if applicable. On procedure day the patient is admitted to an outpatient infusion suite or an inpatient nuclear medicine ward depending on radiation safety and observation needs. The radiopharmaceutical is administered intravenously by a nuclear medicine physician or trained advanced practice provider with appropriate radiation-safety oversight. Post-administration monitoring includes vitals, symptom assessment, and radiation surveys. Follow-up includes delayed imaging to assess biodistribution, laboratory monitoring for marrow or organ toxicity, and scheduled clinical visits to assess response and adverse events. Billing uses 79999 to report the therapy when no specific radiopharmaceutical therapy CPT exists; documentation must support the procedure, dosage, indications, and time spent for appropriate valuation and potential use of applicable modifiers.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    77402Radiation therapy management, design and direction, simple or complexRadiation oncology management codes used when radiation oncologist directs overall therapy planning concurrent with radiopharmaceutical treatment.
    78800Radiopharmaceutical therapy; any method, single administrationUsed for some radiopharmaceutical therapies that have a specific code; 79999 used when no specific code applies.
    78320Bone imaging, whole body; planarDiagnostic nuclear medicine imaging commonly performed before or after therapy to assess disease distribution.
    78106Hepatobiliary imaging, static or dynamic, per study protocolExample of diagnostic nuclear medicine studies that may be used for organ function assessment prior to certain radiopharmaceuticals.
    96365Intravenous infusion, therapeutic, non-chemotherapy; initial 1 hourUsed to report infusion time for some radionuclide administrations when billing rules allow separate infusion codes.
    99070Supplies and materials (e.g., radiopharmaceutical preparation)Used to capture additional non-covered supplies or special preparation materials associated with an investigational or custom radiopharmaceutical.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    2084P0800X
    208000000X
    282N00000X
    363L00000X
    163WP0218X
    177F00000X
    335V00000X

    Related ICD-10-CM Codes

    30 rows

    ICD-10-CM CodeDescription
    C22.0Liver cell carcinoma
    C25.9Malignant neoplasm of pancreas, unspecified
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C50.912Malignant neoplasm of unspecified site of left female breast
    C56.9Malignant neoplasm of unspecified ovary
    C61Malignant neoplasm of prostate
    C64.9Malignant neoplasm of unspecified kidney, except renal pelvis
    C71.9Malignant neoplasm of brain, unspecified
    C73Malignant neoplasm of thyroid gland
    C74.90Malignant neoplasm of unspecified part of unspecified adrenal gland

    Showing 1–10 of 30

    Related Payer Policy Updates

    Specialty: Nephrology1 / 2

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-79005-ORAL-RADIOPHARMACEUTICAL-THERAPY

    CPT 79005: Oral Radiopharmaceutical Therapy

    CPT-79101-RADIOPHARMACEUTICAL-INTRAVENOUS-THERAPY

    CPT 79101: Intravenous Radiopharmaceutical Therapy

    CPT-79200-INTRACAVITARY-RADIOPHARMACEUTICAL-ADMINISTRATION

    CPT 79200: Intracavitary Radiopharmaceutical Administration

    CPT-79300-INTERSTITIAL-BRACHYTHERAPY-IMPLANTATION

    CPT 79300: Brachytherapy Radioactive Seed/Wire Implantation

    CPT-79403-RADIOLABELED-MONOCLONAL-ANTIBODY-INFUSION

    CPT 79403: Intravenous Radiolabeled Monoclonal Antibody Infusion

    CPT-79440-RADIOPHARMACEUTICAL-INJECTION-FOR-SYNOVIAL-INFLAMMATION

    CPT 79440: Therapeutic Radioactive Joint Injection

    CPT-79445-TRANSARTERIAL-RADIOEMBOLIZATION-INTRA-ARTERIAL-RADIOACTIVE-INJECTION

    CPT 79445: Transarterial Radioembolization (Intra-arterial Embolization)

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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