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    v1.0.30
    OpenPayerBilling CodesTherapeutic Nuclear Medicine ProceduresCPT cpt-79300-interstitial-brachytherapy-implantation
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    CPT 79300: Brachytherapy Radioactive Seed/Wire Implantation

    Medicare pays $64 on average nationally for this procedure.

    CPT code 79300 describes implantation of a colloidal radioactive substance contained in wires, small tubes, or seeds placed directly over or into a tumor for localized radiotherapy; service type: brachytherapy seed or implant placement procedure; typical site of service: hospital outpatient department or ambulatory surgical center where invasive radiotherapy implants are performed.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old patient with a localized prostate carcinoma is referred for brachytherapy implantation of radioactive seeds. The patient has undergone preoperative imaging (transrectal ultrasound and CT) to map tumor location and prostate volume. On the day of service the patient presents to an ambulatory surgical center or hospital operating room. Under spinal or general anesthesia, the radiation oncologist and urologist use transrectal ultrasound guidance to place radioactive seeds (I-125 or Pd-103) in needles or strands directly into the prostate peripheral zone covering the tumor and margin. The procedure includes intraoperative dosimetry verification and documentation of seed placement. Postprocedure, the patient is monitored for urinary retention, bleeding, and seed migration, receives discharge instructions, and has planned follow-up with radiation oncology for dosimetric review and oncologic surveillance.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    55875Placement of brachytherapy source, tightly linked (separate procedure code for placement of radioactive source into the prostate via transperineal approach)Alternative prostate brachytherapy technique; may be billed for specific seed implantation approaches or in combination when separate work is performed.
    76930Ultrasound, transrectal; guidance for needle placementOften performed intraoperatively to guide seed placement and dosimetry.
    77295Therapeutic radiology port film for localization and/or verificationUsed for verification imaging of implant position and dosimetry planning when performed separately.
    77811Interstitial radiation source application, complex (e.g., high-energy brachytherapy with special techniques)Brachytherapy-related code for more complex interstitial radiation delivery; may be used for higher-complexity implants or regional techniques.
    77778Brachytherapy physics consultation and treatment planMedical physics services for treatment planning and dose calculations associated with seed implantation.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208600000X
    208800000X
    207P00000X
    207L00000X
    207QG0300X
    310500000X
    103G00000X
    152WP0200X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    C15.3Malignant neoplasm of upper third of esophagus
    C16.9Malignant neoplasm of stomach, unspecified
    C18.9Malignant neoplasm of colon, unspecified
    C22.0Liver cell carcinoma
    C25.9Malignant neoplasm of pancreas, unspecified
    C33Malignant neoplasm of trachea
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C43.9Malignant melanoma of skin, unspecified
    C44.311Basal cell carcinoma of skin of nose
    C49.9Malignant neoplasm of connective and soft tissue, unspecified

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Nephrology1 / 2

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-79005-ORAL-RADIOPHARMACEUTICAL-THERAPY

    CPT 79005: Oral Radiopharmaceutical Therapy

    CPT-79101-RADIOPHARMACEUTICAL-INTRAVENOUS-THERAPY

    CPT 79101: Intravenous Radiopharmaceutical Therapy

    CPT-79200-INTRACAVITARY-RADIOPHARMACEUTICAL-ADMINISTRATION

    CPT 79200: Intracavitary Radiopharmaceutical Administration

    CPT-79403-RADIOLABELED-MONOCLONAL-ANTIBODY-INFUSION

    CPT 79403: Intravenous Radiolabeled Monoclonal Antibody Infusion

    CPT-79440-RADIOPHARMACEUTICAL-INJECTION-FOR-SYNOVIAL-INFLAMMATION

    CPT 79440: Therapeutic Radioactive Joint Injection

    CPT-79445-TRANSARTERIAL-RADIOEMBOLIZATION-INTRA-ARTERIAL-RADIOACTIVE-INJECTION

    CPT 79445: Transarterial Radioembolization (Intra-arterial Embolization)

    CPT-79999-RADIOPHARMACEUTICAL-THERAPY-UNLISTED-PROCEDURE

    CPT 79999: Radiopharmaceutical Therapy, Unlisted Procedure

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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