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    v1.0.30
    OpenPayerBilling CodesTherapeutic Nuclear Medicine ProceduresCPT cpt-79005-oral-radiopharmaceutical-therapy
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    CPT 79005: Oral Radiopharmaceutical Therapy

    Medicare pays $91 on average nationally for this procedure.

    CPT code 79005 describes oral administration of a radiopharmaceutical agent for therapeutic purposes, typically used to treat cancer or related conditions; this service is a radiopharmaceutical therapy procedure (oral administration) usually delivered in an outpatient oncology clinic or specialized nuclear medicine facility where oral dosing and monitoring occur.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with metastatic thyroid carcinoma or neuroendocrine tumor scheduled to receive an oral radiopharmaceutical for targeted systemic therapy. The patient presents to an outpatient nuclear medicine or oncology infusion clinic after multidisciplinary tumor board recommendation. Pre-procedure evaluation includes verification of indication, recent labs (renal and hepatic function), pregnancy test for women of childbearing potential, medication reconciliation, and consent. The nuclear medicine physician or authorized oncology provider reviews prior imaging, documents dosing based on body weight or institutional protocol, and ensures radiation safety counseling. The radiopharmaceutical is administered orally by a licensed provider or authorized nurse under direct supervision. Post-administration monitoring occurs in a designated area for a short observation period to assess for acute adverse effects, with discharge instructions covering radiation precautions, hydration, and follow-up imaging or lab work scheduled as indicated.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    79005Radiopharmaceutical therapy administration, oral; therapeutic, single administrationThis is the primary procedure for oral radiopharmaceutical administration as described.
    78800Radiopharmaceutical localization of tumor or distribution of radiopharmaceutical agent, qualitative; multiple areas, single day imagingPerformed for post-therapy imaging to assess distribution of the agent when required.
    79101Sampling and assay of radioactivity in blood and/or urineUsed when pharmacokinetic monitoring or dosimetry requires bioassay after administration.
    77307Special treatment procedures, includes those requiring complex dosimetry (radiation therapy)May be used for complex dosimetry planning associated with therapeutic radiopharmaceuticals when billed by radiation oncology.
    96413Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drugIncluded as a workflow comparator for systemic therapy visits; not the same route but similar billing and monitoring considerations.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RG0300X
    2085R0202X
    2084N0400X
    363A00000X
    207L00000X
    261QP2400X
    175L00000X
    1223D0004X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C16.9Malignant neoplasm of stomach, unspecified
    C18.9Malignant neoplasm of colon, unspecified
    C20Malignant neoplasm of rectum
    C21.8Malignant neoplasm of overlapping sites of rectum, anus and anal canal
    C22.0Liver cell carcinoma
    C25.9Malignant neoplasm of pancreas, unspecified
    C26.9Malignant neoplasm of ill-defined sites within the digestive system
    C33Malignant neoplasm of trachea
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C50.912Malignant neoplasm of unspecified site of left female breast

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Nephrology1 / 2

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-79101-RADIOPHARMACEUTICAL-INTRAVENOUS-THERAPY

    CPT 79101: Intravenous Radiopharmaceutical Therapy

    CPT-79200-INTRACAVITARY-RADIOPHARMACEUTICAL-ADMINISTRATION

    CPT 79200: Intracavitary Radiopharmaceutical Administration

    CPT-79300-INTERSTITIAL-BRACHYTHERAPY-IMPLANTATION

    CPT 79300: Brachytherapy Radioactive Seed/Wire Implantation

    CPT-79403-RADIOLABELED-MONOCLONAL-ANTIBODY-INFUSION

    CPT 79403: Intravenous Radiolabeled Monoclonal Antibody Infusion

    CPT-79440-RADIOPHARMACEUTICAL-INJECTION-FOR-SYNOVIAL-INFLAMMATION

    CPT 79440: Therapeutic Radioactive Joint Injection

    CPT-79445-TRANSARTERIAL-RADIOEMBOLIZATION-INTRA-ARTERIAL-RADIOACTIVE-INJECTION

    CPT 79445: Transarterial Radioembolization (Intra-arterial Embolization)

    CPT-79999-RADIOPHARMACEUTICAL-THERAPY-UNLISTED-PROCEDURE

    CPT 79999: Radiopharmaceutical Therapy, Unlisted Procedure

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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