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    v1.0.30
    OpenPayerBilling CodesUltrasonic Guidance ProceduresCPT cpt-76965-ultrasound-guided-interstitial-brachytherapy-placement
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    CPT 76965: Ultrasound-Guided Interstitial Radioelement Placement

    Medicare pays $67 on average nationally for this procedure.

    CPT code 76965 describes ultrasound-guided placement of an interstitial radioelement for destruction of a tumor, a minimally invasive image-guided brachytherapy procedure; the service type is image-guided interstitial radioactive element placement, typically performed in an operating room, procedure suite, or interventional radiology suite under sterile conditions using real-time ultrasonic guidance to localize and position the radioactive source within the tumor bed.

    For related coverage guidance, see recent payer policy updates: Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillation, Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillation, Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillation.

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    Table of contents

    Progress1 / 7

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with a localized malignant tumor (for example, a recurrent head and neck squamous cell carcinoma or a small soft-tissue or prostate tumor) for which brachytherapy is indicated. The patient presents to an outpatient surgical or interventional radiology suite after multidisciplinary tumor board review where imaging and pathology confirmed a target amenable to interstitial radioactive seed placement. Pre-procedure planning includes review of prior cross-sectional imaging (CT or MRI), informed consent, review of coagulation status, and administration of local or monitored anesthesia care. In the procedure, the interventionalist uses real-time ultrasonic guidance to place radioactive seeds or sources into the interstitial space of the tumor to deliver a therapeutic radiation dose. Immediate post-placement imaging (ultrasound or CT) confirms positioning and dosimetry. The patient is recovered in the PACU or same-day observation area and discharged with radiation safety instructions and follow-up arranged with radiation oncology for dose verification and surveillance.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    76930Ultrasonic guidance for needle placement (e.g., biopsy, aspiration, injection, localization device), imaging supervision and interpretationOften used when real-time ultrasound guidance is billed for needle or catheter placement associated with interstitial seed insertion.
    77295Therapeutic radiology simulation-aided field settingMay be used in the brachytherapy planning process for dosimetry and treatment setup.
    77778Brachytherapy physics consultation and reviewUsed for physics planning, dosimetry calculations, and quality assurance related to interstitial radioactive element placement.
    57455Colposcopy of the cervix including biopsy(s) and endocervical curettage (when applicable for gynecologic interstitial brachytherapy planning)Performed when gynecologic evaluation or biopsy is necessary before gynecologic brachytherapy.
    51720Implantation of a temporary intraluminal device (e.g., urethral) for radionuclide insertion (example for prostate-related procedures)Performed in select genitourinary brachytherapy workflows when adjunctive devices are placed.

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    58Modifier 58 (Staged or related procedure/service by the same physician during the postoperative period) indicates that a subsequent procedure performed by the same provider during the…- Use modifier 58 when the same physician/QHP performs a procedure during the postoperative/global period of an earlier procedure and the subsequent procedure is either planned or anticipated…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208D00000X
    2084P0800X
    207Q00000X
    207L00000X
    347C00000X
    225XG0600X
    2278P3900X
    207QB0002X

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    C16.9Malignant neoplasm of stomach, unspecified
    C18.9Malignant neoplasm of colon, unspecified
    C20Malignant neoplasm of rectum
    C22.0Liver cell carcinoma
    C25.9Malignant neoplasm of pancreas, unspecified
    C32.9Malignant neoplasm of larynx, unspecified
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C43.9Malignant melanoma of skin, unspecified
    C44.92Squamous cell carcinoma of skin, unspecified
    C50.912Malignant neoplasm of unspecified site of left female breast

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2027-02-05
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2027-02-05
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2027-02-05
    Percutaneous Left Atrial Appendage Closure - Medical PolicyHealth-New-England2027-02-01
    Transcatheter Mitral Valve Repair Medical PolicyHealth-New-England2027-02-01
    Cardiac Electrophysiological (EP) Studies and Cardiac Ablation of Abnormal Electrical RhythmsCigna2027-01-15
    Biomarkers for Myocardial Infarction and Chronic Heart Failure Reimbursement PolicyHealthfirst2026-11-01
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2026-11-01
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2026-11-01
    Cardiology - TryvioCigna2026-11-01

    Related Codes

    CPT-76932-ULTRASOUND-GUIDANCE-ENDOMYOCARDIAL-BIOPSY-IMAGING-INTERPRETATION

    CPT 76932: Ultrasound-Guided Endomyocardial Biopsy Supervision and Interpretation

    CPT-76936-ULTRASOUND-GUIDED-PSEUDOANEURYSM-COMPRESSION-REPAIR

    CPT 76936: Ultrasound Guidance for Pseudoaneurysm/AV Fistula Compression

    CPT-76937-ULTRASOUND-GUIDANCE-VASCULAR-ACCESS

    CPT 76937: Ultrasound Guidance for Vascular Access

    CPT-76940-ULTRASOUND-GUIDANCE-PARENCHYMAL-ABLATION-MONITORING

    CPT 76940: Ultrasound Guidance for Parenchymal Tissue Ablation

    CPT-76941-ULTRASOUND-GUIDANCE-INTRAUTERINE-FETAL-TRANSFUSION-CORDOCENTESIS

    CPT 76941: Imaging Supervision for Intrauterine Fetal Transfusion/Cordocentesis

    CPT-76942-ULTRASOUND-GUIDANCE-NEEDLE-PLACEMENT

    CPT 76942: Ultrasound Guidance for Needle Placement

    CPT-76945-ULTRASOUND-GUIDANCE-CHORIONIC-VILLUS-SAMPLING-SUPERVISION

    CPT 76945: Ultrasound Supervision and Interpretation for Chorionic Villus Sampling

    CPT-76946-ULTRASOUND-GUIDANCE-AMNIOCENTESIS-SUPERVISION-INTERPRETATION

    CPT 76946: Ultrasound Guidance for Amniocentesis Supervision/Interpretation

    CPT-76948-ULTRASOUND-SUPERVISION-INTERPRETATION-OVA-ASPIRATION

    CPT 76948: Ultrasound Guidance for Ovum Aspiration

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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