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    OpenPayerBilling CodesUltrasonic Guidance ProceduresCPT cpt-76946-ultrasound-guidance-amniocentesis-supervision-interpretation
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    CPT 76946: Ultrasound Guidance for Amniocentesis Supervision/Interpretation

    Medicare pays $24 on average nationally for this procedure.

    CPT code 76946 describes ultrasound guidance for imaging supervision and interpretation provided during a separately reportable amniocentesis; the service is an imaging supervision and interpretation procedure used to guide needle placement and confirm sampling of amniotic fluid for fetal testing, typically performed as an invasive diagnostic procedure in an outpatient clinic, hospital outpatient department, or perinatal specialty setting.

    For related coverage guidance, see recent payer policy updates: Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillation, Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillation, Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillation.

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    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old pregnant patient at 16 weeks' gestation is referred for diagnostic amniocentesis after a positive maternal serum screening and abnormal cell-free DNA result indicating increased risk for trisomy 21. The patient is counseled by Maternal-Fetal Medicine and elects to proceed. On the day of procedure, the patient is positioned supine in an ultrasound procedure room within the outpatient obstetric clinic. A targeted ultrasound exam is performed to confirm fetal viability, placental location, and an adequate amniotic fluid pocket. Under sterile conditions and local anesthesia, the operator uses real-time ultrasound guidance to direct a spinal needle through the maternal abdomen into the amniotic sac. A sample of amniotic fluid is withdrawn for genetic and cytogenetic testing. The provider documents imaging supervision and interpretation of the ultrasound guidance during the amniocentesis performed by the same or another qualified clinician. Post-procedure ultrasound confirms fetal motion and absence of immediate complications. The patient is observed briefly and given discharge instructions for signs of complications and follow-up for laboratory results.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    59000Amniocentesis, diagnostic; performed with ultrasound guidance when performedPrimary invasive procedure that yields the amniotic fluid sample; ultrasound guidance for this procedure is reported separately with 76946.
    76801Ultrasound, pregnant uterus, real time with image documentation, fetal and maternal evaluation, first trimesterPre-procedure or concurrent ultrasound evaluation to assess gestational age and anatomy; may be performed before amniocentesis.
    76815Ultrasound, pregnant uterus, real time with image documentation, transabdominal, fetal and maternal evaluation, after first trimesterStandard obstetric ultrasound used to localize fetus and amniotic fluid pockets immediately prior to or during amniocentesis.
    76942Ultrasonic guidance for needle placement (e.g., biopsy, aspiration, injection, localization device), imaging supervision and interpretationRelated ultrasound guidance code used for other non-obstetric needle procedures; provides context for reporting image guidance services.
    99000Application of a sterile dressing (listed under general services)Ancillary service commonly provided after invasive procedures such as amniocentesis for wound care.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208U00000X
    207V00000X
    2084P0800X
    363L00000X
    207Q00000X
    1041S0200X
    3104A0625X
    2355A2700X

    Related ICD-10-CM Codes

    16 rows

    ICD-10-CM CodeDescription
    O09.512Supervision of elderly primigravida, second trimester
    O09.519Supervision of elderly primigravida, unspecified trimester
    O09.522Supervision of elderly multigravida, second trimester
    O09.529Supervision of elderly multigravida, unspecified trimester
    O09.92Supervision of high risk pregnancy, unspecified, second trimester
    O28.1Abnormal biochemical finding on antenatal screening of mother
    O28.3Abnormal ultrasonic finding on antenatal screening of mother
    O36.4XX0Maternal care for intrauterine death, not applicable or unspecified
    O36.4XX1Maternal care for intrauterine death, fetus 1
    O36.80X0Pregnancy with inconclusive fetal viability, not applicable or unspecified

    Showing 1–10 of 16

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2027-02-05
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2027-02-05
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2027-02-05
    Percutaneous Left Atrial Appendage Closure - Medical PolicyHealth-New-England2027-02-01
    Transcatheter Mitral Valve Repair Medical PolicyHealth-New-England2027-02-01
    Cardiac Electrophysiological (EP) Studies and Cardiac Ablation of Abnormal Electrical RhythmsCigna2027-01-15
    Biomarkers for Myocardial Infarction and Chronic Heart Failure Reimbursement PolicyHealthfirst2026-11-01
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2026-11-01
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2026-11-01
    Cardiology - TryvioCigna2026-11-01

    Related Codes

    CPT-76932-ULTRASOUND-GUIDANCE-ENDOMYOCARDIAL-BIOPSY-IMAGING-INTERPRETATION

    CPT 76932: Ultrasound-Guided Endomyocardial Biopsy Supervision and Interpretation

    CPT-76936-ULTRASOUND-GUIDED-PSEUDOANEURYSM-COMPRESSION-REPAIR

    CPT 76936: Ultrasound Guidance for Pseudoaneurysm/AV Fistula Compression

    CPT-76937-ULTRASOUND-GUIDANCE-VASCULAR-ACCESS

    CPT 76937: Ultrasound Guidance for Vascular Access

    CPT-76940-ULTRASOUND-GUIDANCE-PARENCHYMAL-ABLATION-MONITORING

    CPT 76940: Ultrasound Guidance for Parenchymal Tissue Ablation

    CPT-76941-ULTRASOUND-GUIDANCE-INTRAUTERINE-FETAL-TRANSFUSION-CORDOCENTESIS

    CPT 76941: Imaging Supervision for Intrauterine Fetal Transfusion/Cordocentesis

    CPT-76942-ULTRASOUND-GUIDANCE-NEEDLE-PLACEMENT

    CPT 76942: Ultrasound Guidance for Needle Placement

    CPT-76945-ULTRASOUND-GUIDANCE-CHORIONIC-VILLUS-SAMPLING-SUPERVISION

    CPT 76945: Ultrasound Supervision and Interpretation for Chorionic Villus Sampling

    CPT-76948-ULTRASOUND-SUPERVISION-INTERPRETATION-OVA-ASPIRATION

    CPT 76948: Ultrasound Guidance for Ovum Aspiration

    CPT-76965-ULTRASOUND-GUIDED-INTERSTITIAL-BRACHYTHERAPY-PLACEMENT

    CPT 76965: Ultrasound-Guided Interstitial Radioelement Placement

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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