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    v1.0.30
    OpenPayerBilling CodesDiagnostic Radiology (Diagnostic Imaging) Procedures of the Urinary TractCPT cpt-74425-antegrade-urography-imaging-interpretation
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    CPT 74425: Antegrade Urography with Contrast Radiographs

    Medicare pays $93 on average nationally for this procedure.

    CPT code 74425 describes imaging supervision and interpretation for an antegrade urography procedure in which contrast is injected in the direction of normal urinary flow and radiographs are obtained; service type: imaging supervision and interpretation for contrast urography; typical site of service: radiology suite or interventional fluoroscopy room in an outpatient or hospital setting.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old male with a history of recurrent nephrolithiasis presents with flank pain and hematuria. Non-contrast CT suggests obstructing calculi in the proximal ureter and impaired antegrade flow of urine from the affected kidney. The urology team schedules an antegrade pyelography (antegrade urography) to evaluate the collecting system anatomy, confirm level of obstruction, and guide possible percutaneous nephrostomy or stent placement. The patient is transported to the radiology/interventional suite. Under sterile technique, a percutaneous renal access is obtained and contrast is injected in the direction of normal urinary flow while the radiologist supervises imaging acquisition and performs interpretation. Fluoroscopic images and radiographs are obtained to document contrast opacification of the renal pelvis, calyces, ureter, and bladder. Findings are communicated to the urology team, and the report documents technique, volumes and type of contrast used, any complications, and interpretation. Typical site of service: hospital radiology or interventional radiology suite, or outpatient ambulatory surgical center when percutaneous access is performed electively. Service type: imaging supervision and interpretation for antegrade urography with contrast injection in the direction of normal urinary flow.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    50392Percutaneous nephrostomy, with or without injection for radiological evaluation, with catheter placementOften performed immediately before or in conjunction with antegrade urography to establish access and allow contrast injection.
    74420Pyelography, radiologic, antegrade, other than by retrograde catheterization, radiological supervision and interpretationRelated imaging of the renal collecting system; used for antegrade studies depending on technique and coding guidance.
    74430Pyelography, retrograde, radiological supervision and interpretationPerformed when retrograde access via cystoscopy is used instead of antegrade percutaneous approach; may be an alternative in workflow.
    74240Urography, excretory (IVP), radiological supervision and interpretationIntravenous urography performed when antegrade assessment is not indicated or as complementary imaging.
    50432Placement of percutaneous nephroureteral stent with imagingTherapeutic procedures such as stent placement often follow antegrade urography if obstruction is confirmed.
    76942Ultrasonic guidance for needle placement (e.g., for percutaneous renal access)Frequently used to obtain initial percutaneous access prior to contrast injection for antegrade urography.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    27Modifier 27 indicates a separate, subsequent outpatient hospital E/M service provided to the same patient on the same date by a different provider in a hospital outpatient setting. It is a…- Use modifier -27 on facility (hospital outpatient/ambulatory service center) claims to report a subsequent, separate, and distinct outpatient E/M service provided to the same patient on the same…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2086S0102X
    208800000X
    207LC0200X
    3336C0002X
    3140N1450X
    310500000X
    225000000X
    172V00000X

    Related Payer Policy Updates

    Specialty: Nephrology1 / 3

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-74400-INTRAVENOUS-UROGRAPHY-KUB-PYELOGRAPHY

    CPT 74400: Intravenous Urography/Pyelography, Kidneys-Ureters-Bladder

    CPT-74410-IVP-CONTRAST-KIDNEYS-URETERS-BLADDER

    CPT 74410: Intravenous Urography (KUB) with Contrast

    CPT-74415-IV-PYELOGRAPHY-NEPHROTOMOGRAPHY-URINARY-TRACT-XRAY

    CPT 74415: Intravenous Pyelogram with Nephrotomography

    CPT-74420-RETROGRADE-UROGRAPHY-RETROGRADE-PYELOGRAPHY

    CPT 74420: Retrograde Urography (Retrograde Pyelography)

    CPT-74430-URINARY-BLADDER-RADIOGRAPHIC-IMAGING-THREE-VIEWS

    CPT 74430: Radiographic Imaging of Urinary Bladder, ≥3 Views

    CPT-74440-VAS-DEFERENS-SEMINAL-VESICLE-EPIDIDYMIS-IMAGING

    CPT 74440: Imaging of Vas Deferens, Seminal Vesicles, or Epididymis

    CPT-74445-CORPORA-CAVERNOSA-IMAGING-SUPERVISION-INTERPRETATION

    CPT 74445: Corpora Cavernosa Imaging Supervision and Interpretation

    CPT-74450-RETROGRADE-URETHROCYSTOGRAPHY-IMAGING-SUPERVISION-INTERPRETATION

    CPT 74450: Urethrocystography, Retrograde Imaging Supervision and Interpretation

    CPT-74455-VOIDING-URETHROCYSTOGRAPHY-IMAGING-INTERPRETATION

    CPT 74455: Voiding Urethrocystography, Imaging Supervision and Interpretation

    CPT-74470-CONTRAST-IMAGING-FOR-RENAL-CYST-LOCALIZATION

    CPT 74470: Imaging Supervision and Interpretation for Renal Cyst Localization

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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