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    v1.0.30
    OpenPayerBilling CodesRenal Transplantation ProceduresCPT cpt-50370-kidney-allograft-explantation-due-to-rejection
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    CPT 50370: Removal of Failed Transplanted Kidney

    Medicare pays $1183 on average nationally for this procedure.

    CPT code 50370 describes the surgical removal of a previously transplanted donor kidney due to graft failure or rejection; the service is a transplant nephrectomy performed in an operating room or surgical suite and is categorized as an inpatient or outpatient surgical procedure depending on clinical status and institutional setting.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

    Progress1 / 7

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old man with a history of end-stage renal disease underwent deceased-donor kidney transplantation three years prior. He now presents with progressive graft dysfunction over weeks, rising serum creatinine, oliguria, fever, and biopsy-confirmed severe acute rejection with cortical necrosis and irreversible allograft injury. After multidisciplinary review, the transplant surgeon schedules explantation of the failed renal allograft due to medical nonviability, ongoing infection risk, and to prepare the patient for return to dialysis and potential re-transplant evaluation. The clinical workflow includes preoperative evaluation (labs, imaging, crossmatch review, and immunosuppression adjustment), informed consent documenting failed graft removal, intraoperative removal of the transplanted kidney via an open or sometimes laparoscopic approach, hemostasis and management of vascular anastomoses, and immediate postoperative monitoring in a PACU or inpatient unit with attention to hemodynamics, fluid status, wound care, and resumption or modification of immunosuppression and dialysis access planning.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    50370Removal of transplanted kidney (nephrectomy), from recipientPrimary procedure: removal of a previously transplanted donor kidney due to failed graft.
    36556Insertion of tunneled centrally inserted central venous catheter, with subcutaneous port or pump, age 5 years or olderCommonly performed preoperatively or postoperatively to provide reliable vascular access for dialysis when returning the patient to hemodialysis after graft removal.
    49560Removal of infected or nonviable prosthetic material from abdominal wall (Note: example unrelated)Data not available in the input.
    32551Tube thoracostomy, includes water seal, when performed (Note: example unrelated)Data not available in the input.
    99223Initial hospital care, typically 70 minutes or more, per day, for postoperative managementUsed for complex inpatient preoperative or postoperative evaluation and management of the transplant recipient undergoing explantation.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2080P0207X
    2084P0800X
    3336M0002X
    207QP0002X
    207QA0401X
    207RC0000X
    207X00000X
    126800000X

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    A52.03Syphilitic endocarditis
    B37.7Candidal sepsis
    I12.0Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease
    I12.9Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
    I13.0Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
    I13.11Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease
    N17.0Acute kidney failure with tubular necrosis
    N17.9Acute kidney failure, unspecified
    N18.5Chronic kidney disease, stage 5

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Nephrology1 / 3

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-50300-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50300: Nephrectomy, Kidney Removal

    CPT-50320-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50320: Nephrectomy, Removal of Kidney or Partial Kidney

    CPT-50323-CADAVER-DONOR-KIDNEY-BACK-TABLE-PREPARATION

    CPT 50323: Donor Kidney Back Table Preparation (Cadaver)

    CPT-50325-DONOR-KIDNEY-BACK-TABLE-PREPARATION

    CPT 50325: Living Donor Kidney Back Table Preparation

    CPT-50327-RENAL-VEIN-BACKBENCH-RECONSTRUCTION

    CPT 50327: Backbench Venous Reconstruction of Donor Kidney

    CPT-50328-ARTERIAL-ALLOGRAFT-PREPARATION-FOR-KIDNEY-TRANSPLANT

    CPT 50328: Arterial Allograft Preparation for Kidney Transplant

    CPT-50329-RENAL-ALLOGRAFT-PREPARATION-WITH-ARTERIAL-ANASTOMOSIS

    CPT 50329: Renal Allograft Preparation with Arterial Joining

    CPT-50340-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50340: Nephrectomy, Kidney Removal

    CPT-50360-KIDNEY-AND-URETER-TRANSPLANTATION

    CPT 50360: Kidney and Ureter Transplantation

    CPT-50365-KIDNEY-TRANSPLANT-WITH-RECIPIENT-NEPHRECTOMY

    CPT 50365: Kidney and Ureter Transplant with Recipient Nephrectomy

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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