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    OpenPayerBilling CodesRenal Transplantation ProceduresCPT cpt-50300-nephrectomy-kidney-removal
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    CPT 50300: Nephrectomy, Kidney Removal

    CPT code 50300 describes a nephrectomy, the surgical removal of a kidney or part of a kidney, typically performed as an inpatient or outpatient surgical procedure in an operating room or ambulatory surgery center for treatment of renal disease or injury; the service includes surgical excision of renal tissue and related operative care and is used for coding and billing the primary nephrectomy procedure.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 62-year-old male with a solitary renal mass discovered on imaging after hematuria and flank pain. Cross-sectional imaging (CT abdomen/pelvis with contrast) demonstrates a 6.2 cm enhancing mass in the left kidney suspicious for renal cell carcinoma. Preoperative evaluation includes labs (CBC, BMP, coagulation studies), anesthesia assessment, and review of renal function to determine feasibility of partial versus radical nephrectomy. The patient is consented for nephrectomy with possible conversion between partial and radical techniques depending on intraoperative findings.

    Surgical workflow: the patient presents to an ambulatory or inpatient surgical suite (typical site: hospital operating room or ambulatory surgery center for selected cases). After general anesthesia and positioning, the surgeon performs either a laparoscopic/robotic or open approach. Intraoperative steps include vascular control of the renal artery and vein, mobilization of the kidney, resection of tumor or entire kidney, hemostasis, and possible placement of drains. If partial nephrectomy is attempted, intraoperative ultrasound, temporary vascular occlusion (clamping), and renorrhaphy are performed. The specimen is sent to pathology. Postoperative care includes monitoring in PACU, pain control, serial labs for renal function, and discharge planning or admission for further care if indicated.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    50590Laparoscopy, surgical; nephrectomy or nephroureterectomy, including partial or total nephrectomyAlternative minimally invasive approach for partial or radical nephrectomy; billed when a laparoscopic technique is used instead of open 50300.
    50220Nephrectomy, partial, including partial ureterectomy, when performed; with renal reconstruction (including collecting system)Used when a partial nephrectomy with reconstruction is performed instead of a simple or radical nephrectomy.
    50240Nephrectomy, complete, including adrenalectomy when performed; for a nonfunctioning kidneyRelated complete nephrectomy code used for specific indications like nonfunctioning kidney; may be used instead of 50300 depending on documentation.
    50960Renal artery or vein thrombectomy or embolectomy (open); with or without angioplasty, with/without bypassPerformed when vascular complications or tumor thrombus in renal vein require additional vascular work during nephrectomy.
    20985Surgical implant/space placeholder (example)Represents potential implantable device coding when spacer/mesh or drains are placed; used ancillary to nephrectomy when implantable materials are used.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2086S0120X
    207RC0000X
    207VM0101X
    374700000X
    172V00000X
    101YS0200X
    156FX1900X
    2251X0800X

    Related Payer Policy Updates

    Specialty: Nephrology1 / 3

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-50320-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50320: Nephrectomy, Removal of Kidney or Partial Kidney

    CPT-50323-CADAVER-DONOR-KIDNEY-BACK-TABLE-PREPARATION

    CPT 50323: Donor Kidney Back Table Preparation (Cadaver)

    CPT-50325-DONOR-KIDNEY-BACK-TABLE-PREPARATION

    CPT 50325: Living Donor Kidney Back Table Preparation

    CPT-50327-RENAL-VEIN-BACKBENCH-RECONSTRUCTION

    CPT 50327: Backbench Venous Reconstruction of Donor Kidney

    CPT-50328-ARTERIAL-ALLOGRAFT-PREPARATION-FOR-KIDNEY-TRANSPLANT

    CPT 50328: Arterial Allograft Preparation for Kidney Transplant

    CPT-50329-RENAL-ALLOGRAFT-PREPARATION-WITH-ARTERIAL-ANASTOMOSIS

    CPT 50329: Renal Allograft Preparation with Arterial Joining

    CPT-50340-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50340: Nephrectomy, Kidney Removal

    CPT-50360-KIDNEY-AND-URETER-TRANSPLANTATION

    CPT 50360: Kidney and Ureter Transplantation

    CPT-50365-KIDNEY-TRANSPLANT-WITH-RECIPIENT-NEPHRECTOMY

    CPT 50365: Kidney and Ureter Transplant with Recipient Nephrectomy

    CPT-50370-KIDNEY-ALLOGRAFT-EXPLANTATION-DUE-TO-REJECTION

    CPT 50370: Removal of Failed Transplanted Kidney

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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