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    OpenPayerBilling CodesRenal Transplantation ProceduresCPT cpt-50340-nephrectomy-kidney-removal
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    CPT 50340: Nephrectomy, Kidney Removal

    Medicare pays $950 on average nationally for this procedure.

    CPT code 50340 describes a nephrectomy, the surgical removal of a kidney or part of a kidney, typically performed as an operative procedure for conditions such as renal tumor, severe trauma, or nonfunctioning kidney; the service is a surgical procedure usually delivered in an inpatient or outpatient hospital operating room setting depending on clinical factors and approach.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

    Progress1 / 7

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old male with a 3-month history of flank pain and hematuria is diagnosed with a 6.5 cm enhancing mass in the right kidney on contrast CT scan consistent with renal cell carcinoma. After staging shows no metastatic disease, the urologic surgeon schedules a right radical nephrectomy to remove the entire kidney and perinephric fat. The typical clinical workflow includes preoperative evaluation (history, physical, labs including CBC/chemistry, coagulation studies), anesthesia assessment, informed consent with discussion of risks and benefits, perioperative antibiotic prophylaxis, intraoperative removal of the kidney via an open or laparoscopic approach, specimen submission to pathology, postoperative monitoring for hemodynamic stability and urine output from the contralateral kidney, pain control, DVT prophylaxis, and discharge planning with follow-up for pathology results and surveillance.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    50590Ureterolithotomy; pyelolithotomy; extraction of stone from renal pelvis or calyces (separate procedure)May be performed prior to or instead of nephrectomy when stones are source of obstruction; not typical with radical nephrectomy but listed as related renal surgery
    50220Nephroureterectomy, including partial cystectomy; for renal pelvic tumor (radical)Related oncologic procedure when tumor involves renal pelvis and ureter; may be combined or selected instead of 50340 depending on tumor extent
    50335Nephrectomy, partial, including cortical wedge resection (partial nephrectomy)Performed when nephron-sparing surgery is indicated for smaller renal masses; alternative to radical nephrectomy represented by 50340
    47562Laparoscopy, surgical; nephrectomy (including partial nephrectomy), morcellation if performedRepresents laparoscopic approach codes often used for minimally invasive nephrectomy procedures related to 50340 which is an open code
    99223Initial hospital care, typically 70 minutes or moreCommon inpatient E/M for preoperative or postoperative management of a complex patient undergoing nephrectomy

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    2080P0201X
    226300000X
    207ZN0500X
    111NI0013X
    163WD1100X
    343900000X
    246XS1301X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C64.1Malignant neoplasm of right kidney, except renal pelvis
    C64.9Malignant neoplasm of unspecified kidney, except renal pelvis
    C65.9Malignant neoplasm of unspecified renal pelvis
    C66.9Malignant neoplasm of unspecified ureter
    C68.9Malignant neoplasm of urinary organ, unspecified
    D63.1Anemia in chronic kidney disease
    I12.0Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease
    I13.10Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
    N13.2Hydronephrosis with renal and ureteral calculous obstruction
    N18.4Chronic kidney disease, stage 4 (severe)

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Nephrology1 / 3

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-50300-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50300: Nephrectomy, Kidney Removal

    CPT-50320-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50320: Nephrectomy, Removal of Kidney or Partial Kidney

    CPT-50323-CADAVER-DONOR-KIDNEY-BACK-TABLE-PREPARATION

    CPT 50323: Donor Kidney Back Table Preparation (Cadaver)

    CPT-50325-DONOR-KIDNEY-BACK-TABLE-PREPARATION

    CPT 50325: Living Donor Kidney Back Table Preparation

    CPT-50327-RENAL-VEIN-BACKBENCH-RECONSTRUCTION

    CPT 50327: Backbench Venous Reconstruction of Donor Kidney

    CPT-50328-ARTERIAL-ALLOGRAFT-PREPARATION-FOR-KIDNEY-TRANSPLANT

    CPT 50328: Arterial Allograft Preparation for Kidney Transplant

    CPT-50329-RENAL-ALLOGRAFT-PREPARATION-WITH-ARTERIAL-ANASTOMOSIS

    CPT 50329: Renal Allograft Preparation with Arterial Joining

    CPT-50360-KIDNEY-AND-URETER-TRANSPLANTATION

    CPT 50360: Kidney and Ureter Transplantation

    CPT-50365-KIDNEY-TRANSPLANT-WITH-RECIPIENT-NEPHRECTOMY

    CPT 50365: Kidney and Ureter Transplant with Recipient Nephrectomy

    CPT-50370-KIDNEY-ALLOGRAFT-EXPLANTATION-DUE-TO-REJECTION

    CPT 50370: Removal of Failed Transplanted Kidney

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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