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    v1.0.30
    OpenPayerBilling CodesRenal Transplantation ProceduresCPT cpt-50365-kidney-transplant-with-recipient-nephrectomy
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    CPT 50365: Kidney and Ureter Transplant with Recipient Nephrectomy

    Medicare pays $2825 on average nationally for this procedure.

    CPT code 50365 describes transplantation of a kidney and ureter from a cadaveric or living donor into a recipient with concurrent removal of the recipient’s native kidney (nephrectomy); service type: organ transplant surgery; typical site of service: inpatient hospital operating room and transplant unit.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with end-stage renal disease (ESRD) or irreversible chronic kidney failure who is scheduled to receive a kidney transplant. The recipient may be receiving a kidney from a living related or unrelated donor or from a deceased (cadaveric) donor. The surgical team performs removal of the recipient's failed native kidney (nephrectomy) as part of the transplant operation when indicated (for example, a large polycystic kidney, recurrent infection, or space considerations) and implants the donor kidney and ureter into the recipient's iliac fossa with vascular anastomoses to the external or internal iliac vessels and ureteroneocystostomy to the bladder.

    Key clinical workflow steps:

    • Preoperative evaluation: transplant surgeon, nephrologist, anesthesiology assessment, crossmatch and immunologic testing, infectious disease screening, and preoperative imaging.

    • Operative procedure: general anesthesia; recipient nephrectomy performed if indicated; donor kidney and ureter implanted; arterial and venous anastomoses performed; ureter implanted into bladder with stent as needed; hemostasis and closure.

    • Immediate postoperative care: ICU or step-down monitoring for hemodynamics, urine output, fluid/electrolyte management, immunosuppression initiation, and monitoring for graft function and surgical complications.

    • Follow-up: inpatient recovery, serial labs (creatinine, electrolytes), imaging as indicated, transplant clinic follow-up, and adjustment of immunosuppressive therapy.

    Typical site of service: hospital inpatient operating room with possible immediate ICU or transplant unit admission postoperatively.

    Service type: major surgical procedure — kidney transplant with recipient nephrectomy (open surgical transplant).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    50360Transplantation of kidney from living donor; with recipient nephrectomyAlternate code used when donor is living and specific descriptor differs — closely related surgical variant
    88305Surgical pathology, gross and microscopic examinationPerformed on native nephrectomy specimens when pathologic evaluation is required
    36556Insertion of non-tunneled centrally inserted central venous catheter; age 5 years or olderUsed for perioperative vascular access for plasmapheresis, dialysis, or medication administration as part of transplant care
    36415Collection of venous blood by venipunctureRoutine pre- and postoperative laboratory testing for transplant patients
    93975Duplex scan of renal transplant (e.g., arterial and venous evaluation)

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2080P0206X
    208800000X
    207RH0000X
    207XX0005X
    207SG0203X
    2471B0102X
    261QC0050X
    163WN0003X

    Related Payer Policy Updates

    Specialty: Nephrology1 / 3

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-50300-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50300: Nephrectomy, Kidney Removal

    CPT-50320-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50320: Nephrectomy, Removal of Kidney or Partial Kidney

    CPT-50323-CADAVER-DONOR-KIDNEY-BACK-TABLE-PREPARATION

    CPT 50323: Donor Kidney Back Table Preparation (Cadaver)

    CPT-50325-DONOR-KIDNEY-BACK-TABLE-PREPARATION

    CPT 50325: Living Donor Kidney Back Table Preparation

    CPT-50327-RENAL-VEIN-BACKBENCH-RECONSTRUCTION

    CPT 50327: Backbench Venous Reconstruction of Donor Kidney

    CPT-50328-ARTERIAL-ALLOGRAFT-PREPARATION-FOR-KIDNEY-TRANSPLANT

    CPT 50328: Arterial Allograft Preparation for Kidney Transplant

    CPT-50329-RENAL-ALLOGRAFT-PREPARATION-WITH-ARTERIAL-ANASTOMOSIS

    CPT 50329: Renal Allograft Preparation with Arterial Joining

    CPT-50340-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50340: Nephrectomy, Kidney Removal

    CPT-50360-KIDNEY-AND-URETER-TRANSPLANTATION

    CPT 50360: Kidney and Ureter Transplantation

    CPT-50370-KIDNEY-ALLOGRAFT-EXPLANTATION-DUE-TO-REJECTION

    CPT 50370: Removal of Failed Transplanted Kidney

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    Performed postoperatively to evaluate graft perfusion and vascular patency
    99223Initial hospital care, high severityTypical inpatient initial hospital care code used by admitting physicians for complex transplant recipients