Loading...

    Explore
    • Policy Monitoring
    • Live Policy Feed
    • Billing Codes
    • NPI Medicare & Medicaid
    • Healthcare Providers
    • Health Insurance Payers
    • States
    • Service Lines
    • Taxonomy Codes
    Lookup tools
    • Billing Code Lookup
    • CPT Modifier Lookup
    • Provider Taxonomy Code Lookup
    • Healthcare Provider & Facility Lookup
    • Health Insurance Payer Lookup
    • Payer Contact Directory

    Policy & Benchmark Tools

    • Prior Authorization Lookup
    • Coverage Criteria Lookup
    • Timely Filing Lookup
    • Billing Code Reimbursement Rates
    • Payer Comparison Dashboard
    • Facility Comparison Dashboard
    • All tools

    Company

    • About OpenPayer
    • Data Sources
    • Trek Health
    OpenPayerby Trek Health
    LinkedInYouTube

    © 2026 Trek Health. All rights reserved.

    OpenPayer is built and maintained by Trek Health.

    v1.0.30
    OpenPayerBilling CodesRenal Transplantation ProceduresCPT cpt-50320-nephrectomy-kidney-removal
    Ask Trek AI about this page

    CPT 50320: Nephrectomy, Removal of Kidney or Partial Kidney

    Medicare pays $1502 on average nationally for this procedure.

    CPT code 50320 describes a nephrectomy, a surgical procedure for removal of a kidney or part of a kidney, typically performed as an open surgical major operative procedure for conditions such as renal tumor, severe trauma, or nonfunctioning kidney; the service is commonly provided in an inpatient hospital or ambulatory surgery center setting depending on clinical complexity and patient status.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

    Customize your policy alerts

    Sign up for cpt 50320 policy alerts

    Get alerted when payer policies referencing 50320 are released or updated.

    Monitor payer policy activity

    Receive email alerts as soon as relevant payer policies are published or updated.

    Table of contents

    Progress1 / 7

    Explore openpayer tools

    • Billing CodesCPT, HCPCS, DRG & more
    • Reimbursement RatesCommercial vs. Medicare rate reports
    • Facility ComparisonBeds, revenue & payer mix
    • ProvidersHospitals & facilities
    • PayersPlans & market footprint
    • Taxonomy CodesNUCC specialty codes
    • ModifiersCPT modifiers & usage
    • Prior AuthorizationPA policies by payer & drug
    • Timely FilingFiling deadlines by payer
    • Coverage CriteriaMedical necessity by payer
    • Payer ContactsClaims, PA & appeals contacts
    View all tools

    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 62-year-old adult presenting with a renal mass identified incidentally on abdominal imaging or with hematuria and flank pain. After cross-sectional imaging (CT or MRI) and preoperative assessment, the patient is scheduled for a nephrectomy — either radical nephrectomy for suspected or confirmed renal cell carcinoma or partial nephrectomy for a small, localized tumor. The clinical workflow includes preoperative evaluation (history, labs, anesthesia assessment), imaging review, informed consent, perioperative antibiotics, general anesthesia with possible regional block, intraoperative removal of the kidney or portion of the kidney with hemostasis, possible lymph node sampling, placement of drains if needed, and postoperative monitoring in PACU with discharge planning or inpatient admission for postoperative care and pathology follow-up.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    50220Nephroureterectomy, partial or complete, with removal of ureter and bladder cuffPerformed when tumor involves the renal pelvis or ureter; may be indicated instead of simple nephrectomy.
    50590Lithotripsy, percutaneous, nephrostolithotomy, with or without ultrasonic fragmentationPerformed for large renal calculi; may be done preoperatively or in staged care if stones complicate renal surgery.
    50545Nephrostomy, percutaneous, with or without aspiration, single kidneyMay be placed preoperatively for drainage of infected hydronephrosis or decompression prior to nephrectomy.
    88305Level IV surgical pathology, gross and microscopic examinationPathology examination of nephrectomy specimen to establish tumor type, margins, and staging.
    99223Initial hospital care, per day, high severityTypical inpatient evaluation and management code for complex postoperative care after major nephrectomy.

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    2080P0210X
    2086S0122X
    2278H0200X
    246QH0600X
    405300000X
    207SG0201X
    3418M1120X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    C64.1Malignant neoplasm of right kidney, except renal pelvis
    C64.2Malignant neoplasm of left kidney, except renal pelvis
    C64.9Malignant neoplasm of unspecified kidney, except renal pelvis
    C65.9Malignant neoplasm of unspecified renal pelvis
    D09.0Carcinoma in situ of bladder
    I12.9Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
    I13.10Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
    I13.11Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease
    N03.9Chronic nephritic syndrome with unspecified morphologic changes
    N04.9Nephrotic syndrome with unspecified morphologic changes

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Nephrology1 / 3

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-50300-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50300: Nephrectomy, Kidney Removal

    CPT-50323-CADAVER-DONOR-KIDNEY-BACK-TABLE-PREPARATION

    CPT 50323: Donor Kidney Back Table Preparation (Cadaver)

    CPT-50325-DONOR-KIDNEY-BACK-TABLE-PREPARATION

    CPT 50325: Living Donor Kidney Back Table Preparation

    CPT-50327-RENAL-VEIN-BACKBENCH-RECONSTRUCTION

    CPT 50327: Backbench Venous Reconstruction of Donor Kidney

    CPT-50328-ARTERIAL-ALLOGRAFT-PREPARATION-FOR-KIDNEY-TRANSPLANT

    CPT 50328: Arterial Allograft Preparation for Kidney Transplant

    CPT-50329-RENAL-ALLOGRAFT-PREPARATION-WITH-ARTERIAL-ANASTOMOSIS

    CPT 50329: Renal Allograft Preparation with Arterial Joining

    CPT-50340-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50340: Nephrectomy, Kidney Removal

    CPT-50360-KIDNEY-AND-URETER-TRANSPLANTATION

    CPT 50360: Kidney and Ureter Transplantation

    CPT-50365-KIDNEY-TRANSPLANT-WITH-RECIPIENT-NEPHRECTOMY

    CPT 50365: Kidney and Ureter Transplant with Recipient Nephrectomy

    CPT-50370-KIDNEY-ALLOGRAFT-EXPLANTATION-DUE-TO-REJECTION

    CPT 50370: Removal of Failed Transplanted Kidney

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
    Published by

    Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.