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    OpenPayerBilling CodesEndoscopy Procedures on the RectumCPT cpt-45384-colonoscopy-hot-biopsy-forceps-lesion-removal
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    CPT 45384: Flexible Colonoscopy with Removal Using Hot Biopsy Forceps

    Medicare pays $559 and commercial payers pay $802 on average nationally for this procedure.

    CPT code 45384 describes a flexible colonoscopy procedure in which a colonoscope is used to examine the rectum and colon and remove one or more tumors, polyps, or other lesions using hot biopsy forceps; service type: endoscopic therapeutic polypectomy/lesion removal; typical site of service: outpatient endoscopy suite or ambulatory surgery center.

    For related coverage guidance, see recent payer policy updates: Esophagogastroduodenoscopy (EGD) Coverage Policy, Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD), Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver Disease.

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    National Reimbursement Benchmarks

    Across national payers, Medicare’s mean of $558.8 sits below BUCA’s average commercial mean of $802.4, indicating that BUCA reimbursements are roughly $243.6 higher on average than Medicare for CPT 45384. This gap highlights a material difference between a federal program’s payment level and a representative commercial payer’s average, with Medicare’s 47 localities summarizing a tighter centralized schedule versus BUCA’s broader commercial positioning.

    Dispersion measured as P75 minus P25 shows variability is widest for Blue Cross Blue Shield (BCBS) with a range of $822.0 ($1,405.6 − $568.7), followed by UnitedHealth Group at $549.6 ($871.1 − $417.5). The tightest spreads are Aetna at $366.9 ($455.1 − $84.2) and Cigna at $407.2 ($743.8 − $343.6). BUCA’s interquartile range is $642.0 ($1,098.9 − $445.7), and Medicare’s IQR is $62.0 ($582 − $520), illustrating much narrower local variation for Medicare versus most commercial payers.

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    National Payer Mean Reimbursement Rates

    State Reimbursement Rates

    State: Alaska1 / 51

    Rate by payer

    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old patient presents to a gastroenterology outpatient endoscopy suite after fecal occult blood testing and colon cancer screening identified positive findings and a surveillance colonoscopy was indicated. The patient has a history of an adenomatous polyp at a prior colonoscopy and intermittent rectal bleeding. After pre-procedure assessment, moderate sedation is administered and the gastroenterologist advances a flexible colonoscope to the lesion site. One or more polyps or mucosal lesions are identified in the rectum or distal colon and are removed using hot biopsy forceps (electrocautery applied through forceps) for excision and hemostasis. Tissue is sent for pathology and the patient is recovered in the PACU before discharge with post-procedure instructions. Typical documentation captures indication, informed consent, sedation type, insertion and withdrawal times, lesion size and location, technique (hot biopsy forceps), number of specimens, complications (if any), and disposition.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    45385Colonoscopy, flexible, proximal to splenic flexure; with removal of tumor(s), polyp(s), or other lesion(s) by snare techniqueAlternative therapeutic technique for polyp removal when snare polypectomy is used instead of hot biopsy forceps; may be selected based on lesion morphology.
    45380

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    74Modifier ‑74 indicates an outpatient hospital or ASC procedure that was discontinued after anesthesia was administered and after the procedure had begun. Use this modifier when anesthesia (local,…- Use modifier -74 when a procedure in an outpatient hospital or ASC setting is terminated after anesthesia has been administered and after the procedure has commenced (for example, after incision,…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RG0100XGastroenterology PhysicianAn internist who specializes in diagnosis and treatment of diseases of the digestive organs including the stomach, bowels, liver and gallbladder. This…
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    208600000XSurgery PhysicianA general surgeon has expertise related to the diagnosis - preoperative, operative and postoperative management - and management of complications of s…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    2278G1100XGeneral Care Certified Respiratory TherapistThis level of care includes diagnostics testing, therapeutics, monitoring, rehabilitation of patients with disorders of the cardiopulmonary system, as…
    163WH0200XHome Health Registered NurseNursing Service Providers · Registered Nurse
    261QA3000XAugmentative Communication Clinic/CenterAn entity, facility, or distinct part of a facility staffed by audiology and/or speech professionals with special training in the evaluation of a pati…
    246QH0401XHemapheresis PractitionerTechnologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Pathology

    Related ICD-10-CM Codes

    20 rows

    ICD-10-CM CodeDescription
    C18.0Malignant neoplasm of cecum
    C18.1Malignant neoplasm of appendix
    C18.2Malignant neoplasm of ascending colon
    C18.3Malignant neoplasm of hepatic flexure
    C18.4Malignant neoplasm of transverse colon
    C18.5Malignant neoplasm of splenic flexure
    C18.6Malignant neoplasm of descending colon
    C18.7Malignant neoplasm of sigmoid colon
    C18.8Malignant neoplasm of overlapping sites of colon
    C19Malignant neoplasm of rectosigmoid junction

    Showing 1–10 of 20

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01
    Celiac Disease TestingOscar Health2026-10-01
    Laboratory Testing for the Diagnosis of Inflammatory Bowel DiseaseOscar Health2026-10-01
    Percutaneous Electrical Nerve Field Stimulation (PENFS)Cigna2026-09-15
    Colorectal Cancer ScreeningBlue Cross Blue Shield - New Mexico2026-09-04

    Related Codes

    CPT-45300-PROCTOSIGMOIDOSCOPY-RIGID-DIAGNOSTIC

    CPT 45300: Diagnostic Proctosigmoidoscopy with Rigid Proctoscope

    CPT-45303-PROCTOSIGMOIDOSCOPY-WITH-STRICTURE-DILATION

    CPT 45303: Proctosigmoidoscopy with Stricture Dilation

    CPT-45305-PROCTOSIGMOIDOSCOPY-WITH-BIOPSY

    CPT 45305: Proctosigmoidoscopy with Biopsy

    CPT-45307-PROCTOSIGMOIDOSCOPY-LOWER-GI-ENDOSCOPY

    CPT 45307: Proctosigmoidoscopy of Rectum and Sigmoid Colon

    CPT-45308-PROCTOSIGMOIDOSCOPIC-LESION-REMOVAL

    CPT 45308: Proctosigmoidoscopy with Removal of Single Lesion

    CPT-45309-PROCTOSIGMOIDOSCOPY-SNARE-EXCISION-LESION

    CPT 45309: Proctosigmoidoscopy with Snare Polypectomy

    CPT-45315-PROCTOSIGMOIDOSCOPIC-POLYPECTOMY-MULTIPLE-LESIONS

    CPT 45315: Proctosigmoidoscopy with Multiple Lesion Removal

    CPT-45317-PROCTOSIGMOIDOSCOPY-WITH-HEMOSTASIS

    CPT 45317: Therapeutic Proctosigmoidoscopy for Hemorrhage Control

    CPT-45320-PROCTOSIGMOIDOSCOPIC-LESION-ABLATION

    CPT 45320: Proctosigmoidoscopic Ablation of Lesion

    CPT-45321-PROCTOSIGMOIDOSCOPIC-DECOMPRESSION-SIGMOID-VOLVULUS

    CPT 45321: Proctosigmoidoscopic Decompression of Volvulus

    Showing 1–10 of 39

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    Colonoscopy, flexible, proximal to splenic flexure; with biopsy, single or multiple
    Diagnostic biopsy procedure performed when sampling mucosa without polypectomy is indicated; often performed if lesions are not amenable to removal at that encounter.