CPT code 45315 represents proctosigmoidoscopic removal of multiple tumors, polyps, or lesions using a rigid proctosigmoidoscope with techniques such as hot biopsy forceps, bipolar cautery, or snare. This procedure is clinically important for diagnosis and treatment of distal colorectal pathology and can prevent progression of neoplastic lesions. Nationally, the code is relevant for outpatient endoscopy workflow, quality measurement for lesion removal, and payer coverage determinations for colorectal care.

Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical intent and typical sites of service, a summary of common modifiers associated with procedural billing practice, and contextual guidance on how the code is classified within outpatient endoscopy service lines. The publication covers benchmarks and utilization context, coding and billing considerations, and how payers commonly approach coverage and authorization for endoscopic polypectomy procedures.

This summary provides a national perspective useful to coding specialists, clinical billing teams, and policy analysts seeking clarity on procedural scope, service settings, and payer applicability for CPT code 45315.