CPT code 45308 denotes a proctosigmoidoscopic procedure in which a provider inspects the anus, rectum, and sigmoid colon with a proctosigmoid scope and removes a single tumor, polyp, or lesion using hot biopsy forceps or bipolar cautery. Nationally, this code reflects a common minor endoscopic surgical intervention that combines diagnostic visualization with definitive lesion removal in the distal colon and rectum.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise clinical context for the procedure, typical sites of service, and the common operational considerations that influence coding and billing for endoscopic lesion removal. The publication outlines benchmark-oriented elements such as utilization patterns, relative place-of-service expectations, and coding comparators where available. It also flags areas for policy attention, including payer-specific coverage variances and documentation expectations that commonly affect claim adjudication.

The piece is intended for revenue cycle leaders, coding professionals, and clinical managers seeking a national-level primer on the clinical purpose and billing context of CPT code 45308, along with an overview of what to examine when validating claims or evaluating practice workflows.