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    v1.0.28
    OpenPayerBilling CodesEndoscopic Small Intestine ProceduresCPT cpt-44378-upper-gi-endoscopy-bleeding-control
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    CPT 44378: Upper GI Endoscopy with Therapeutic Hemostasis

    CPT code 44378 describes an upper gastrointestinal endoscopic procedure in which the provider performs a visual examination from the esophagus through the small intestine to identify sources of bleeding and employs endoscopic techniques to control hemorrhage; service type: upper GI endoscopy with therapeutic hemostasis; typical site of service: endoscopy suite or operating room in an outpatient or inpatient hospital setting.

    For related coverage guidance, see recent payer policy updates: Esophagogastroduodenoscopy (EGD) Coverage Policy, Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD), Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant Testing.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old male presents to the emergency department with acute onset melena and lightheadedness. He has a history of chronic NSAID use for osteoarthritis and chronic alcohol use. Hemoglobin is 7.8 g/dL and vital signs show transient orthostatic hypotension. After initial resuscitation with IV fluids and transfusion as needed, the gastroenterology team performs an urgent diagnostic and therapeutic upper endoscopy using a lighted endoscope to evaluate the entire upper gastrointestinal tract from esophagus to ileum for active bleeding. During the procedure the endoscopist identifies a bleeding duodenal ulcer and applies endoscopic hemostatic techniques (injection of epinephrine, thermal coagulation, and placement of endoscopic clips). The typical workflow includes pre-procedure consent and review of anticoagulation status, sedation or anesthesia evaluation (conscious sedation or monitored anesthesia care), the procedure in an endoscopy suite or operating room, post-procedure recovery with monitoring for rebleeding, and documentation of findings and therapeutic maneuvers performed.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43235Upper gastrointestinal endoscopy including esophagus, stomach, and either the duodenum; diagnostic, with or without collection of specimen(s)Diagnostic upper endoscopy often performed when bleeding source is suspected; may be billed when no therapeutic hemostasis is performed or when separate diagnostic scope precedes therapy.
    43255Upper gastrointestinal endoscopy with control of bleeding, any methodAlternate endoscopic code for control of bleeding in the upper GI tract; used for specific therapeutic maneuvers depending on CPT guidance and anatomy.
    43239Upper gastrointestinal endoscopy, flexible, transoral; with biopsy, single or multiplePerformed when biopsies are obtained during the endoscopic evaluation of a bleeding lesion.
    43840Laparoscopic repair of perforation of gastroduodenal ulcer, with or without vagotomySurgical code representing operative management when endoscopic therapy fails and surgery is required for complications such as perforation.
    43254Upper gastrointestinal endoscopy with gastric dilationPerformed when dilation is needed for associated strictures encountered during evaluation; may be adjunctive to bleeding control if indicated.
    91110Chromoendoscopy or application of hemostatic agent (injectable) (example procedural adjunct)Represents therapeutic adjuncts used during endoscopic hemostasis; billed separately only when supported by payer policy and documentation.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    207VM0101XMaternal & Fetal Medicine PhysicianAn obstetrician/gynecologist who cares for, or provides consultation on, patients with complications of pregnancy. This specialist has advanced knowle…
    163WP1700XPerinatal Registered NurseNursing Service Providers · Registered Nurse
    364SN0000XNeonatal Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    207LH0002XHospice and Palliative Medicine (Anesthesiology) PhysicianAn anesthesiologist with special knowledge and skills to prevent and relieve the suffering experienced by patients with life-limiting illnesses. This …

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    D50.9Iron deficiency anemia, unspecified
    D62Acute posthemorrhagic anemia
    I85.00Esophageal varices without bleeding
    I85.01Esophageal varices with bleeding
    K21.9Gastro-esophageal reflux disease without esophagitis
    K25.0Acute gastric ulcer with hemorrhage
    K25.2Acute gastric ulcer with both hemorrhage and perforation
    K26.0Acute duodenal ulcer with hemorrhage
    K26.2Acute duodenal ulcer with both hemorrhage and perforation
    K27.0Acute peptic ulcer, site unspecified, with hemorrhage

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    7 rows

    PolicyPayerEffective Date
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01
    Celiac Disease TestingOscar Health2026-10-01

    Related Codes

    CPT-44360-UPPER-SMALL-BOWEL-ENDOSCOPY-JEJUNUM-BRUSHING

    CPT 44360: Endoscopic Exam of Duodenum and Jejunum with Brushing

    CPT-44361-ENDOSCOPY-PROXIMAL-SMALL-INTESTINE-BIOPSY

    CPT 44361: Endoscopy Beyond Second Duodenum with Biopsy

    CPT-44363-ENDOSCOPIC-JEJUNAL-INTUBATION-FOREIGN-BODY-REMOVAL

    CPT 44363: Endoscopy of Duodenum and Jejunum with Foreign Body Removal

    CPT-44364-SMALL-BOWEL-ENDOSCOPY-SNARE-POLYPECTOMY

    CPT 44364: Small-Bowel Enteroscopy with Snare Polypectomy

    CPT-44365-SMALL-INTESTINE-ENDOSCOPY-LESION-REMOVAL

    CPT 44365: Endoscopy Beyond Second Duodenum with Hot Biopsy or Bipolar Cautery

    CPT-44366-UPPER-SMALL-BOWEL-ENDOSCOPY-HEMOSTASIS

    CPT 44366: Endoscopic Small-Bowel Exam Beyond Duodenum with Hemostasis

    CPT-44369-ENDOSCOPIC-LASER-RADIOFREQUENCY-ABLATION-SMALL-BOWEL

    CPT 44369: Endoscopic Small Bowel Laser/Radiofrequency Ablation

    CPT-44370-UPPER-GI-ENDOSCOPY-DILATION-STENT-PLACEMENT

    CPT 44370: Endoscopic Dilation and Stent Placement in Upper GI

    CPT-44372-ENDOSCOPIC-JEJUNAL-FEEDING-TUBE-PLACEMENT

    CPT 44372: Endoscopic Jejunostomy Tube Placement

    CPT-44373-GASTROSTOMY-TO-JEJUNOSTOMY-CONVERSION-ENDOSCOPIC

    CPT 44373: Conversion of Gastrostomy Tube to Jejunostomy via Abdominal Approach

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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