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    v1.0.30
    OpenPayerBilling CodesEndoscopic Small Intestine ProceduresCPT cpt-44376-diagnostic-upper-endoscopy-brushing-lavage
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    CPT 44376: Upper GI Endoscopy with Brush Cytology

    Medicare pays $253 on average nationally for this procedure.

    CPT code 44376 describes a diagnostic upper gastrointestinal endoscopic visual examination using a lighted endoscope from the esophagus through the ileum with collection of mucosal specimens by brushing or irrigation and suction for submission to pathology; service type: endoscopic diagnostic procedure with brush cytology; typical site of service: endoscopy suite or hospital outpatient department.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient presents to the gastroenterology clinic with progressive dysphagia, intermittent upper abdominal pain, and unexplained weight loss. The gastroenterologist schedules an upper endoscopic evaluation with mucosal brushing and washings for cytology to evaluate for suspected esophageal or gastric malignancy and to sample suspicious mucosal lesions. The patient arrives at an ambulatory endoscopy suite where nursing performs pre-procedure assessment and obtains informed consent. Conscious sedation is administered by the procedural team (or monitored anesthesia care if indicated). The provider advances a diagnostic upper endoscope from the oropharynx through the esophagus, stomach, and duodenum to the ileum as clinically indicated, performs a systematic visual inspection, documents mucosal findings, and, when abnormal mucosa is seen, collects cytologic specimens by passing a brush through the endoscope and/or performs a lavage with instillation and suctioning of warmed saline. Specimens are placed in appropriate media and sent to pathology for cytologic and histopathologic analysis. Post-procedure recovery is monitored in the endoscopy recovery area and discharge instructions are provided. Typical site of service is an outpatient ambulatory surgery center or hospital endoscopy suite. Service type: diagnostic endoscopic upper gastrointestinal evaluation with brushing/washings for cytology/histopathology.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43235Esophagogastroduodenoscopy, flexible, transoral; with biopsy, single or multipleFrequently performed in the same session when tissue biopsy (forceps) is taken in addition to brushings/washings.
    43239Esophagogastroduodenoscopy, flexible, transoral; with removal of foreign body(s)May be used when a foreign body is encountered and removed during diagnostic endoscopy.
    43249Endoscopy, flexible; small intestine, enteroscopy, diagnostic, beyond the duodenum, without biopsyUsed when the exam is extended into the small bowel beyond standard upper EGD for additional visualization.
    44388Colonoscopy, flexible; diagnostic, including collection of specimens by brushing or washingRelated specimen collection techniques in the lower GI tract; analogous procedure code for colon evaluations using brushings/washings.
    43202Esophagoscopy, rigid or flexible; with dilationMay be used when therapeutic dilation is performed during the endoscopic session for stenosis discovered on diagnostic exam.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    208000000X
    363LF0000X
    111NR0200X
    207X00000X
    347B00000X
    207RS0012X
    2279P3800X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    C15.9Malignant neoplasm of esophagus, unspecified
    C16.9Malignant neoplasm of stomach, unspecified
    D12.6Benign neoplasm of colon, unspecified
    K21.9Gastro-esophageal reflux disease without esophagitis
    K22.2Esophageal obstruction
    K25.9Gastric ulcer, unspecified as acute or chronic, without hemorrhage or perforation
    K26.9Duodenal ulcer, unspecified as acute or chronic, without hemorrhage or perforation
    K27.9Peptic ulcer, site unspecified, unspecified as acute or chronic, without hemorrhage or perforation
    K28.9Gastrojejunal ulcer, unspecified as acute or chronic, without hemorrhage or perforation
    K29.70Gastritis, unspecified, without bleeding

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-44360-UPPER-SMALL-BOWEL-ENDOSCOPY-JEJUNUM-BRUSHING

    CPT 44360: Endoscopic Exam of Duodenum and Jejunum with Brushing

    CPT-44361-ENDOSCOPY-PROXIMAL-SMALL-INTESTINE-BIOPSY

    CPT 44361: Endoscopy Beyond Second Duodenum with Biopsy

    CPT-44363-ENDOSCOPIC-JEJUNAL-INTUBATION-FOREIGN-BODY-REMOVAL

    CPT 44363: Endoscopy of Duodenum and Jejunum with Foreign Body Removal

    CPT-44364-SMALL-BOWEL-ENDOSCOPY-SNARE-POLYPECTOMY

    CPT 44364: Small-Bowel Enteroscopy with Snare Polypectomy

    CPT-44365-SMALL-INTESTINE-ENDOSCOPY-LESION-REMOVAL

    CPT 44365: Endoscopy Beyond Second Duodenum with Hot Biopsy or Bipolar Cautery

    CPT-44366-UPPER-SMALL-BOWEL-ENDOSCOPY-HEMOSTASIS

    CPT 44366: Endoscopic Small-Bowel Exam Beyond Duodenum with Hemostasis

    CPT-44369-ENDOSCOPIC-LASER-RADIOFREQUENCY-ABLATION-SMALL-BOWEL

    CPT 44369: Endoscopic Small Bowel Laser/Radiofrequency Ablation

    CPT-44370-UPPER-GI-ENDOSCOPY-DILATION-STENT-PLACEMENT

    CPT 44370: Endoscopic Dilation and Stent Placement in Upper GI

    CPT-44372-ENDOSCOPIC-JEJUNAL-FEEDING-TUBE-PLACEMENT

    CPT 44372: Endoscopic Jejunostomy Tube Placement

    CPT-44373-GASTROSTOMY-TO-JEJUNOSTOMY-CONVERSION-ENDOSCOPIC

    CPT 44373: Conversion of Gastrostomy Tube to Jejunostomy via Abdominal Approach

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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