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    OpenPayerBilling CodesEndoscopic Small Intestine ProceduresCPT cpt-44365-small-intestine-endoscopy-lesion-removal
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    CPT 44365: Endoscopy Beyond Second Duodenum with Hot Biopsy or Bipolar Cautery

    Medicare pays $164 on average nationally for this procedure.

    CPT code 44365 describes an endoscopic examination of the small intestine extending beyond the second portion of the duodenum but not including the ileum, performed with removal of one or more tumors, polyps, or other lesions using hot biopsy forceps or bipolar cautery; service type: diagnostic and operative endoscopy, typical site of service: outpatient endoscopy suite or ambulatory surgical center (or hospital outpatient department).

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old male presents to the outpatient endoscopy suite with intermittent melena and iron-deficiency anemia. Prior noninvasive testing (fecal occult blood and labs) suggests occult GI blood loss. The gastroenterology team schedules an upper endoscopic evaluation extending past the second portion of the duodenum to inspect the jejunum up to but not including the ileum using a push enteroscope. During the procedure, the provider identifies one or more pedunculated and sessile polyps in the proximal jejunum and removes them using hot biopsy forceps and bipolar cautery to achieve complete excision and hemostasis. The clinical workflow includes pre-procedure consent and chart review, administration of moderate sedation in the endoscopy suite, endoscopic inspection and lesion removal with electrocautery, specimen collection for pathology, post-procedure recovery and discharge instructions, and documentation of procedural details, findings, and immediate complications if any. Typical site of service: hospital outpatient endoscopy unit or ambulatory surgical center. Service type: diagnostic and therapeutic endoscopy (push enteroscopy) with electrocautery polypectomy using hot biopsy forceps/bipolar cautery.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43235Upper gastrointestinal endoscopy including esophagus, stomach, and either the duodenum and/or jejunum when performed — diagnostic, with or without collection of specimen(s) by brushing or washingPerformed when proximal upper GI exam is required; may precede push enteroscopy or be an alternative diagnostic approach.
    44388Colonoscopy, flexible, proximal to the splenic flexure; with endoscopic mucosal resection (EMR)Related therapeutic polypectomy technique in the lower GI tract; similar principles of lesion removal and hemostasis.
    45380Colonoscopy, flexible; with removal of tumor(s), polyp(s), or other lesion(s) by hot biopsy forcepsAnalogous technique in colon that uses hot biopsy forceps; coding parallels for technique-based removal.
    43239Upper gastrointestinal endoscopy with biopsy, single or multipleOften performed alongside diagnostic endoscopy to obtain mucosal biopsies if additional small-bowel biopsies are indicated.
    99152Moderate sedation services provided by the same physician performing the procedure (initial 15 minutes) — (Note: verify local payer rules)Sedation billing that may be relevant when provider documents and bills for moderate sedation during endoscopy per payer policy.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    207PE0004X
    1835X0200X
    207LP2900X
    261QB0400X
    2278P1005X
    152WP0200X
    261QM1103X

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-44360-UPPER-SMALL-BOWEL-ENDOSCOPY-JEJUNUM-BRUSHING

    CPT 44360: Endoscopic Exam of Duodenum and Jejunum with Brushing

    CPT-44361-ENDOSCOPY-PROXIMAL-SMALL-INTESTINE-BIOPSY

    CPT 44361: Endoscopy Beyond Second Duodenum with Biopsy

    CPT-44363-ENDOSCOPIC-JEJUNAL-INTUBATION-FOREIGN-BODY-REMOVAL

    CPT 44363: Endoscopy of Duodenum and Jejunum with Foreign Body Removal

    CPT-44364-SMALL-BOWEL-ENDOSCOPY-SNARE-POLYPECTOMY

    CPT 44364: Small-Bowel Enteroscopy with Snare Polypectomy

    CPT-44366-UPPER-SMALL-BOWEL-ENDOSCOPY-HEMOSTASIS

    CPT 44366: Endoscopic Small-Bowel Exam Beyond Duodenum with Hemostasis

    CPT-44369-ENDOSCOPIC-LASER-RADIOFREQUENCY-ABLATION-SMALL-BOWEL

    CPT 44369: Endoscopic Small Bowel Laser/Radiofrequency Ablation

    CPT-44370-UPPER-GI-ENDOSCOPY-DILATION-STENT-PLACEMENT

    CPT 44370: Endoscopic Dilation and Stent Placement in Upper GI

    CPT-44372-ENDOSCOPIC-JEJUNAL-FEEDING-TUBE-PLACEMENT

    CPT 44372: Endoscopic Jejunostomy Tube Placement

    CPT-44373-GASTROSTOMY-TO-JEJUNOSTOMY-CONVERSION-ENDOSCOPIC

    CPT 44373: Conversion of Gastrostomy Tube to Jejunostomy via Abdominal Approach

    CPT-44376-DIAGNOSTIC-UPPER-ENDOSCOPY-BRUSHING-LAVAGE

    CPT 44376: Upper GI Endoscopy with Brush Cytology

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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