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    v1.0.30
    OpenPayerBilling CodesOther Transcatheteral ProceduresCPT cpt-37213-catheter-directed-thrombolytic-infusion
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    CPT 37213: Catheter-Directed Thrombolysis, Subsequent Day (Noncoronary)

    Medicare pays $203 on average nationally for this procedure.

    CPT code 37213 describes catheter-directed infusion of thrombolytic medication with radiological supervision and interpretation for treatment of a thrombus on a subsequent day of therapy (noncoronary vessel); the service involves insertion and management of a catheter with catheter contrast injection and catheter repositioning or replacement as needed, typically performed by an interventional radiologist or vascular specialist in an inpatient or outpatient hospital interventional suite or endovascular lab.

    For related coverage guidance, see recent payer policy updates: Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood Pressure, Cardiology - Ivabradine, Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 65-year-old individual presenting with acute limb ischemia due to an arterial thrombus of a lower extremity. After vascular surgery and interventional radiology evaluation, the care team initiates catheter-directed thrombolysis to restore distal perfusion. The procedure is performed in an interventional radiology or endovascular suite under conscious sedation or monitored anesthesia care. The interventionalist obtains arterial access (commonly common femoral artery), advances a multi-sidehole infusion catheter into the thrombosed segment under fluoroscopic guidance, and begins continuous infusion of a thrombolytic agent (for example, alteplase) with serial angiographic assessments. The documented service for a subsequent treatment day of an ongoing thrombolytic infusion (when clot lysis requires repeated catheter-directed infusion but is not a coronary vessel) is billed with 37213. Clinical workflow elements include pre-procedure consent and coagulation assessment, vascular access and catheter placement, radiological supervision and interpretation during infusion and possible catheter repositioning or contrast injection, monitoring in the recovery area or ICU during therapy, and documentation of daily procedural notes that justify subsequent-day catheter-directed infusion therapy using 37213.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36215Selective catheter placement, arterial, initial third order or more selective catheterization, radiological supervision and interpretation.Performed prior to or during 37213 to obtain access and selectively catheterize the target arterial segment for thrombolytic infusion.
    36216Selective catheter placement, arterial, each additional second-order or more selective catheter, radiological supervision and interpretation.Used when additional selective catheterization is required in the same vascular territory during the infusion course.
    75898Transcatheter therapy, infusion for thrombolysis; radiological supervision and interpretation.Alternate or adjunct code set for transcatheter infusion procedures; may be used in different payer systems for similar services.
    92941Thrombolysis, intracoronary, pharmacological agent via catheter (used for coronary vessels).Not used for non-coronary vessel thrombolysis but important to differentiate since 37213 excludes coronary vessels.
    76937Ultrasound guidance for vascular access.Often used when ultrasound guidance is applied for arterial access placement prior to catheter-directed thrombolysis.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2080P0206X
    208100000X
    208D00000X
    207RG0100X
    363L00000X
    261QA0005X
    261QR0401X
    163WM0102X

    Related ICD-10-CM Codes

    20 rows

    ICD-10-CM CodeDescription
    G45.8Other transient cerebral ischemic attacks and related syndromes
    G45.9Transient cerebral ischemic attack, unspecified
    I21.3ST elevation (STEMI) myocardial infarction of unspecified site
    I26.99Other pulmonary embolism without acute cor pulmonale
    I74.01Saddle embolus of abdominal aorta
    I74.09Other arterial embolism and thrombosis of abdominal aorta
    I74.3Embolism and thrombosis of arteries of the lower extremities
    I80.219Phlebitis and thrombophlebitis of unspecified iliac vein
    I82.401Acute embolism and thrombosis of unspecified deep veins of right lower extremity
    I82.402Acute embolism and thrombosis of unspecified deep veins of left lower extremity

    Showing 1–10 of 20

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood PressureBluecross Idaho2026-11-01
    Cardiology - IvabradineCigna2026-10-15
    Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA)univerahealthcare2026-10-15
    Percutaneous Ventricular Assist DeviceUnitedHealthcare2026-10-01
    Cardiovascular Disease Risk AssessmentOscar Health2026-10-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2026-10-01
    Multiple Procedure Payment Reduction for Diagnostic Cardiovascular ProceduresBlue Cross Blue Shield - Maine2026-10-01
    Left Atrial Appendage Closure Devicesexcellus_health_plan_inc2026-09-17
    Left Atrial Appendage Closure Devicesuniverahealthcare2026-09-17
    Cardiac Omnibus CodesCigna2026-09-15

    Related Codes

    CPT-37191-INFERIOR-VENA-CAVA-FILTER-PLACEMENT

    CPT 37191: Inferior Vena Cava Filter Placement, Percutaneous

    CPT-37192-IVC-FILTER-REPOSITIONING-IMAGE-GUIDED

    CPT 37192: Reposition Inferior Vena Cava Filter

    CPT-37193-IVC-FILTER-REMOVAL-PERCUTANEOUS

    CPT 37193: Percutaneous IVC Filter Removal

    CPT-37195-CEREBRAL-THROMBOLYTIC-INFUSION

    CPT 37195: Catheter-Directed Intracerebral Thrombolytic Infusion

    CPT-37197-PERCUTANEOUS-ENDOVASCULAR-FOREIGN-BODY-REMOVAL

    CPT 37197: Endovascular Percutaneous Removal of Foreign Body

    CPT-37200-TRANSCATHETER-VASCULAR-BIOPSY

    CPT 37200: Transcatheter Vascular Biopsy

    CPT-37211-CATHETER-DIRECTED-THROMBOLYSIS-ARTERIAL

    CPT 37211: Catheter-Directed Arterial Thrombolysis, Initial Day

    CPT-37212-CATHETER-DIRECTED-THROMBOLYSIS-VENOUS

    CPT 37212: Catheter-Directed Venous Thrombolysis with Radiologic Supervision

    CPT-37214-CATHETER-DIRECTED-THROMBOLYTIC-INFUSION

    CPT 37214: Catheter-Directed Thrombolysis for Noncoronary Vessels

    CPT-37215-CAROTID-ARTERY-STENT-PLACEMENT-EMBOLIC-PROTECTION

    CPT 37215: Carotid Artery Stent Placement with Embolic Protection

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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