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    v1.0.30
    OpenPayerBilling CodesOther Transcatheteral ProceduresCPT cpt-37195-cerebral-thrombolytic-infusion
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    CPT 37195: Catheter-Directed Intracerebral Thrombolytic Infusion

    CPT code 37195 describes catheter-directed infusion of a thrombolytic agent into a cerebral (brain) blood vessel to dissolve an intracranial clot and restore cerebral blood flow; this is an endovascular thrombolytic infusion procedure typically performed by interventional neuroradiology or endovascular neurosurgery teams and is usually provided in an inpatient hospital or specialized endovascular suite for acute ischemic stroke management.

    For related coverage guidance, see recent payer policy updates: Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood Pressure, Cardiology - Ivabradine, Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA).

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old patient presents to the emergency department with sudden-onset right-sided weakness, facial droop, and expressive aphasia that began 90 minutes earlier. Neurologic exam and an NIH Stroke Scale score suggest an acute ischemic stroke. Non-contrast head CT excludes hemorrhage. CT angiography demonstrates an occlusion of a major cerebral artery. The interventional team is consulted and prepares for intra-arterial thrombolytic infusion. The patient is transported to the angiography suite. Under conscious sedation or general anesthesia depending on airway and agitation, vascular access is obtained (commonly via common femoral arterial access) and a microcatheter is navigated to the site of occlusion. A thrombolytic agent is infused through the catheter into the cerebral vessel to dissolve the clot. The team monitors neurologic status, hemodynamics, and post-procedure neuroimaging is performed to assess reperfusion and rule out hemorrhagic conversion. The procedure is billed using 37195 for intra-arterial thrombolytic infusion to a cerebral vessel. Typical workflow involves ED stroke activation, rapid imaging, interventional radiology or neurointerventionalist consultation, angiographic procedure with intra-arterial drug delivery, and post-procedure ICU or stroke unit monitoring.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36215Selective catheter placement, cerebral, internal carotid, vertebral, or major branch, with angiography when performed; initial vesselOften performed before 37195 to access and visualize the occluded cerebral artery and guide catheter placement.
    36245Selective catheter placement, intracranial, with angiography; each additional branch, or separately catheterized vesselUsed for additional intracranial vessel catheterizations during the same angiographic session as 37195.
    61645Cerebral thrombectomy, percutaneous, mechanical (includes radiological supervision and interpretation)Mechanical thrombectomy is commonly performed alongside or instead of intra-arterial thrombolytic infusion; may be combined depending on case.
    70496CT angiography, head and neck, with contrast (includes non-invasive vascular imaging)CT angiography is commonly performed prior to 37195 for diagnosis and procedural planning.
    99152Moderate sedation services provided by the same physician performing the procedure (for initial 15 minutes)Moderate sedation is often billed when conscious sedation is used during intra-arterial procedures; report per payer rules.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    2084P0800X
    208D00000X
    163WN0003X
    2081S0010X
    305S00000X
    111NI0013X
    202K00000X

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood PressureBluecross Idaho2026-11-01
    Cardiology - IvabradineCigna2026-10-15
    Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA)univerahealthcare2026-10-15
    Percutaneous Ventricular Assist DeviceUnitedHealthcare2026-10-01
    Cardiovascular Disease Risk AssessmentOscar Health2026-10-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2026-10-01
    Multiple Procedure Payment Reduction for Diagnostic Cardiovascular ProceduresBlue Cross Blue Shield - Maine2026-10-01
    Left Atrial Appendage Closure Devicesexcellus_health_plan_inc2026-09-17
    Left Atrial Appendage Closure Devicesuniverahealthcare2026-09-17
    Cardiac Omnibus CodesCigna2026-09-15

    Related Codes

    CPT-37191-INFERIOR-VENA-CAVA-FILTER-PLACEMENT

    CPT 37191: Inferior Vena Cava Filter Placement, Percutaneous

    CPT-37192-IVC-FILTER-REPOSITIONING-IMAGE-GUIDED

    CPT 37192: Reposition Inferior Vena Cava Filter

    CPT-37193-IVC-FILTER-REMOVAL-PERCUTANEOUS

    CPT 37193: Percutaneous IVC Filter Removal

    CPT-37197-PERCUTANEOUS-ENDOVASCULAR-FOREIGN-BODY-REMOVAL

    CPT 37197: Endovascular Percutaneous Removal of Foreign Body

    CPT-37200-TRANSCATHETER-VASCULAR-BIOPSY

    CPT 37200: Transcatheter Vascular Biopsy

    CPT-37211-CATHETER-DIRECTED-THROMBOLYSIS-ARTERIAL

    CPT 37211: Catheter-Directed Arterial Thrombolysis, Initial Day

    CPT-37212-CATHETER-DIRECTED-THROMBOLYSIS-VENOUS

    CPT 37212: Catheter-Directed Venous Thrombolysis with Radiologic Supervision

    CPT-37213-CATHETER-DIRECTED-THROMBOLYTIC-INFUSION

    CPT 37213: Catheter-Directed Thrombolysis, Subsequent Day (Noncoronary)

    CPT-37214-CATHETER-DIRECTED-THROMBOLYTIC-INFUSION

    CPT 37214: Catheter-Directed Thrombolysis for Noncoronary Vessels

    CPT-37215-CAROTID-ARTERY-STENT-PLACEMENT-EMBOLIC-PROTECTION

    CPT 37215: Carotid Artery Stent Placement with Embolic Protection

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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