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    v1.0.30
    OpenPayerBilling CodesOther Transcatheteral ProceduresCPT cpt-37211-catheter-directed-thrombolysis-arterial
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    CPT 37211: Catheter-Directed Arterial Thrombolysis, Initial Day

    Medicare pays $340 on average nationally for this procedure.

    CPT code 37211 describes catheter-directed infusion of a thrombolytic agent into an artery (excluding coronary and non‑intracranial arteries) for treatment of a localized arterial thrombus, with radiological supervision and interpretation provided by the same physician; this is the code for the initial day of treatment, typically delivered as an endovascular interventional radiology service in an inpatient or outpatient hospital angiography suite or interventional radiology lab.

    For related coverage guidance, see recent payer policy updates: Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood Pressure, Cardiology - Ivabradine, Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old patient with acute limb ischemia presents to the hospital with sudden onset severe pain, pallor, and pulselessness of the right lower extremity. Vascular surgery and interventional radiology evaluate the patient and determine catheter-directed thrombolysis is indicated to dissolve an arterial thrombus in the popliteal artery to restore perfusion. On the initial treatment day the interventionalist obtains arterial access (commonly common femoral artery), navigates a catheter into the occluded arterial segment under fluoroscopic guidance, administers a thrombolytic infusion (e.g., tissue plasminogen activator) into the clot, and performs radiological supervision and interpretation during catheter placement and infusion initiation. The procedure is typically performed in an interventional radiology suite or hybrid operating room with continuous monitoring and potential vascular surgery backup. Post-procedure, the patient is observed in a monitored bed for neurovascular checks, laboratory monitoring (including coagulation parameters), and assessment for bleeding complications; subsequent infusion days use follow-on codes for continuation of therapy if required.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    37211Catheter-directed thrombolysis, arterial, not coronary or intracranial, initial treatment day — including radiological supervision and interpretationPrimary code for the initial day of catheter-directed arterial thrombolytic infusion for a non-coronary, non-intracranial arterial occlusion.
    37212Catheter-directed thrombolysis, arterial, not coronary or intracranial, subsequent infusion(s) by same physician (per day)Billed for each additional treatment day of catheter-directed arterial thrombolysis after the initial day when continued infusion is required.
    36215Selective catheter placement, arterial system; each first-order thoracic, abdominal, or pelvic branch, inclusiveUsed for selective catheter placement into the vessel supplying the occluded segment prior to thrombolytic infusion when separate from thrombolysis work.
    36216Selective catheter placement, arterial system; each additional second-order or third-order branch, when performedUsed for additional selective catheter maneuvers in the arterial tree as needed to reach the thrombus.
    75898Radiological supervision and interpretation; intraprocedural radiological supervision and interpretation for vascular radiologic proceduresMay be reported as applicable when additional radiologic supervision/interpretation time is significant and billable separate from the global service, per payer rules.
    37618Venous thrombectomy, mechanical, percutaneous; single or multiple venous segments (when venous adjunct procedures are required)Used when concomitant percutaneous venous interventions are performed in the same setting for venous thrombotic disease; included here for completeness when differential vascular pathology is treated.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    208100000X
    208000000X
    281P00000X
    246Y00000X
    246ZB0500X
    1835I0206X
    163WR0006X

    Related ICD-10-CM Codes

    19 rows

    ICD-10-CM CodeDescription
    G45.0Vertebro-basilar artery syndrome
    G45.9Transient cerebral ischemic attack, unspecified
    I26.99Other pulmonary embolism without acute cor pulmonale
    I63.6Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
    I63.9Cerebral infarction, unspecified
    I65.21Occlusion and stenosis of right carotid artery
    I65.29Occlusion and stenosis of unspecified carotid artery
    I72.3Aneurysm of iliac artery
    I73.9Peripheral vascular disease, unspecified
    I74.2Embolism and thrombosis of arteries of the upper extremities

    Showing 1–10 of 19

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood PressureBluecross Idaho2026-11-01
    Cardiology - IvabradineCigna2026-10-15
    Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA)univerahealthcare2026-10-15
    Percutaneous Ventricular Assist DeviceUnitedHealthcare2026-10-01
    Cardiovascular Disease Risk AssessmentOscar Health2026-10-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2026-10-01
    Multiple Procedure Payment Reduction for Diagnostic Cardiovascular ProceduresBlue Cross Blue Shield - Maine2026-10-01
    Left Atrial Appendage Closure Devicesexcellus_health_plan_inc2026-09-17
    Left Atrial Appendage Closure Devicesuniverahealthcare2026-09-17
    Cardiac Omnibus CodesCigna2026-09-15

    Related Codes

    CPT-37191-INFERIOR-VENA-CAVA-FILTER-PLACEMENT

    CPT 37191: Inferior Vena Cava Filter Placement, Percutaneous

    CPT-37192-IVC-FILTER-REPOSITIONING-IMAGE-GUIDED

    CPT 37192: Reposition Inferior Vena Cava Filter

    CPT-37193-IVC-FILTER-REMOVAL-PERCUTANEOUS

    CPT 37193: Percutaneous IVC Filter Removal

    CPT-37195-CEREBRAL-THROMBOLYTIC-INFUSION

    CPT 37195: Catheter-Directed Intracerebral Thrombolytic Infusion

    CPT-37197-PERCUTANEOUS-ENDOVASCULAR-FOREIGN-BODY-REMOVAL

    CPT 37197: Endovascular Percutaneous Removal of Foreign Body

    CPT-37200-TRANSCATHETER-VASCULAR-BIOPSY

    CPT 37200: Transcatheter Vascular Biopsy

    CPT-37212-CATHETER-DIRECTED-THROMBOLYSIS-VENOUS

    CPT 37212: Catheter-Directed Venous Thrombolysis with Radiologic Supervision

    CPT-37213-CATHETER-DIRECTED-THROMBOLYTIC-INFUSION

    CPT 37213: Catheter-Directed Thrombolysis, Subsequent Day (Noncoronary)

    CPT-37214-CATHETER-DIRECTED-THROMBOLYTIC-INFUSION

    CPT 37214: Catheter-Directed Thrombolysis for Noncoronary Vessels

    CPT-37215-CAROTID-ARTERY-STENT-PLACEMENT-EMBOLIC-PROTECTION

    CPT 37215: Carotid Artery Stent Placement with Embolic Protection

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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