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    OpenPayerBilling CodesThromboendarterectomy Procedures on Arteries and VeinsCPT cpt-35321-axillary-brachial-artery-thrombectomy-endarterectomy
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    CPT 35321: Axillary or Brachial Artery Thrombectomy/Endarterectomy

    Medicare pays $828 on average nationally for this procedure.

    CPT code 35321 describes surgical removal of thrombus and plaques from the axillary or brachial artery, a vascular thrombectomy/endarterectomy procedure performed to restore arterial blood flow; service type: open surgical arterial thrombectomy/endarterectomy; typical site of service: operating room or surgical suite in a hospital or ambulatory surgery center.

    For related coverage guidance, see recent payer policy updates: Dental Anesthesia Services, Anesthesia Services for Interventional Pain Management Procedures in an Adult, General Anesthesia and Conscious Sedation Services.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male with a history of peripheral arterial disease and poorly controlled diabetes presents with acute onset of worsening right upper extremity claudication, coolness, pallor, and diminished radial pulse. Diagnostic arterial duplex and CT angiography demonstrate an occlusive thrombus with superimposed atherosclerotic plaque in the right brachial artery with compromised distal perfusion. Vascular surgery evaluates the patient in the hospital and schedules an open embolectomy/thrombectomy of the brachial artery with removal of thrombus and plaque under general anesthesia. The typical clinical workflow includes preoperative assessment and consent, intraoperative vascular exposure of the axillary or brachial artery, arteriotomy, manual or instrument thrombus and plaque removal, possible intraoperative angiography or completion duplex to confirm flow, arterial repair or patch angioplasty as indicated, postoperative monitoring in a recovery unit, anticoagulation management, and discharge planning with vascular follow-up.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    35321Thrombectomy, axillary or brachial artery; removal of thrombus and plaquesPrimary procedure code for open removal of thrombus and plaque from axillary or brachial artery.
    35221Thrombectomy, femoral or popliteal artery; with or without patch angioplastyFrequently performed for lower extremity arterial thromboembolectomy in similar clinical presentations; analogous technique and coding considerations.
    35721Thrombectomy, tibial or peroneal artery, with or without transluminal angioplastyMay be performed for distal runoff procedures when distal emboli are present after brachial thrombectomy.
    35266Embolectomy, with or without thrombectomy, upper arm arteries (humeral)Related procedure for adjacent arterial segments in the upper extremity; used when more distal arterial segments require intervention.
    36247Selective catheter placement, arterial system; each first order thoracic branch, for diagnostic angiographyUsed when intraoperative or preoperative angiography is performed to localize occlusion or confirm flow after thrombectomy.
    99024Postoperative follow-up visit global periodUsed for routine postoperative evaluation during the global surgical period following the thrombectomy.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    2080P0206X
    208800000X
    133NN1002X
    1710I1002X
    335U00000X
    2470A2800X
    246QH0000X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    E11.51Type 2 diabetes mellitus with diabetic peripheral angiopathy without gangrene
    E78.5Hyperlipidemia, unspecified
    I65.21Occlusion and stenosis of right carotid artery
    I65.22Occlusion and stenosis of left carotid artery
    I70.201Unspecified atherosclerosis of native arteries of extremities, right leg
    I70.211Atherosclerosis of native arteries of extremities with intermittent claudication, right leg
    I70.221Atherosclerosis of native arteries of extremities with rest pain, right leg
    I70.231Atherosclerosis of native arteries of right leg with ulceration of thigh
    I70.412Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, left leg
    I70.413Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, bilateral legs

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Dental Anesthesia ServicesProvidence Health Plan2026-10-01
    Anesthesia Services for Interventional Pain Management Procedures in an AdultCigna2026-09-15
    General Anesthesia and Conscious Sedation ServicesUnitedHealthcare2026-09-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21

    Related Codes

    CPT-35301-CAROTID-VERTEBRAL-SUBCLAVIAN-THROMBOENDARTERECTOMY

    CPT 35301: Thromboendarterectomy/Thrombectomy, Carotid/Vertebral/Subclavian

    CPT-35302-SUPERFICIAL-FEMORAL-ARTERY-THROMBECTOMY-ATHERCTOMY

    CPT 35302: Superficial Femoral Artery Thrombectomy/Endarterectomy

    CPT-35303-POPLITEAL-ARTERY-THROMBUS-PLAQUE-REMOVAL

    CPT 35303: Popliteal Artery Thrombectomy/Endarterectomy

    CPT-35304-TIBIOPERONEAL-TRUNK-THROMBECTOMY-ENDARTERECTOMY

    CPT 35304: Tibioperoneal Trunk Thrombectomy and Plaque Removal

    CPT-35305-TIBIAL-PERONEAL-ARTERY-THROMBECTOMY-PLAQUE-REMOVAL

    CPT 35305: Thromboendarterectomy of Tibial or Peroneal Artery

    CPT-35306-ADDITIONAL-TIBIAL-PERONEAL-ARTERY-THROMBOENDARTERECTOMY

    CPT 35306: Additional Tibial or Peroneal Artery Thromboendarterectomy

    CPT-35311-THORACIC-SUBCLAVIAN-INNOMINATE-ARTERY-THROMBECTOMY-ENDARTERECTOMY

    CPT 35311: Subclavian/Innominate Artery Thrombus and Plaque Removal

    CPT-35331-ABDOMINAL-AORTIC-THROMBECTOMY-ENDARTERECTOMY

    CPT 35331: Abdominal Aortic Thrombectomy/Endarterectomy

    CPT-35341-MESENTERIC-CELIAC-RENAL-ARTERY-THROMBUS-PLAQUE-REMOVAL

    CPT 35341: Thrombus/Plaque Removal, Mesenteric/Celiac/Renal Artery

    CPT-35351-ILIAC-ARTERY-THROMBUS-ENDARTERECTOMY

    CPT 35351: Iliac Artery Thrombectomy/Endarterectomy

    Showing 1–10 of 16

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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