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    OpenPayerBilling CodesIntroduction Procedures on the BreastCPT cpt-19294-tumor-cavity-preparation-iort-partial-mastectomy
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    CPT 19294: Tumor Cavity Preparation for Intraoperative Radiation Therapy

    Medicare pays $148 on average nationally for this procedure.

    CPT code 19294 describes the surgical preparation of a tumor cavity for placement of a device used to deliver intraoperative radiation therapy (IORT) during the same operative session as a partial mastectomy; service type: surgical oncology procedure to prepare the lumpectomy/tumor bed for IORT; typical site of service: operating room in an inpatient or outpatient surgical setting during partial mastectomy.

    For related coverage guidance, see recent payer policy updates: Removal of Implantable, Outpatient Surgical Procedures - Site of Service, Surgical Procedures.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old woman with an early-stage, unifocal invasive ductal carcinoma of the breast presents for breast-conserving surgery. The surgical oncology team performs a partial mastectomy (lumpectomy) under general anesthesia. In the same operative session, the surgeon prepares the tumor cavity for placement of an intraoperative radiation therapy (IORT) device to deliver a single fraction of radiation directly to the tumor bed. The workflow includes: preoperative multidisciplinary planning with radiation oncology to confirm candidacy for IORT; intraoperative lumpectomy with margin assessment; mobilization and preparation of the lumpectomy cavity to accept the IORT applicator (device sizing, hemostasis, and packing as needed); placement and securement of the IORT device; delivery of the prescribed intraoperative radiation dose; device removal and standard wound closure; and postoperative handoff to recovery. The procedure coded by 19294 documents the surgeon’s work in preparing the tumor cavity for device placement during the same session as the partial mastectomy.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    19301Partial mastectomy (lumpectomy), with or without axillary samplingThe primary breast-conserving surgical procedure performed in the same session; 19294 is reported when preparing the tumor cavity for IORT during this operation
    77263Special medical radiation physics consultation, review and interpretation prior to complex radiation therapyPreoperative or intraoperative radiation physics planning and consultation associated with IORT device commissioning and dose planning
    77520Insertion or repositioning of radiation source (brachytherapy), interstitialRelated to device placement and radiation delivery techniques; performed by radiation oncology team when intraoperative radiation sources are placed or managed
    77499Unlisted radiation therapy procedureUsed when a specific IORT delivery or device-related procedure lacks an exact CPT descriptor and an unlisted radiation code is required for billing
    99024Postoperative follow-up visit, related to routine postoperative care during postoperative periodGlobal period postoperative visits after the partial mastectomy and IORT session for routine follow-up and wound assessment

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    2084P0800X
    363L00000X
    363A00000X
    2471V0106X
    261QX0203X
    363LP0808X
    225100000X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    C50.111Malignant neoplasm of central portion of right female breast
    C50.112Malignant neoplasm of central portion of left female breast
    C50.121Malignant neoplasm of central portion of right male breast
    C50.122Malignant neoplasm of central portion of left male breast
    C50.211Malignant neoplasm of upper-inner quadrant of right female breast
    C50.212Malignant neoplasm of upper-inner quadrant of left female breast
    C50.311Malignant neoplasm of lower-inner quadrant of right female breast
    C50.312Malignant neoplasm of lower-inner quadrant of left female breast
    C50.411Malignant neoplasm of upper-outer quadrant of right female breast
    C50.412Malignant neoplasm of upper-outer quadrant of left female breast

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Removal of ImplantableBlue Cross Blue Shield - Rhode Island2026-10-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Surgical ProceduresUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Medical Necessity Guidelines Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01

    Related Codes

    CPT-19281-BREAST-LESION-LOCALIZATION-MAMMOGRAPHIC-GUIDANCE

    CPT 19281: Mammographic-Guided Breast Lesion Localization, First Lesion

    CPT-19282-BREAST-LOCALIZATION-DEVICE-PLACEMENT-MAMMOGRAPHIC-GUIDANCE

    CPT 19282: Mammographic-Guided Breast Localization Add-On

    CPT-19283-STEREOTACTIC-BREAST-LESION-LOCALIZATION-FIRST-LESION

    CPT 19283: Stereotactic Breast Lesion Localization, First Lesion

    CPT-19284-STEREOTACTIC-BREAST-LOCALIZATION-ADD-ON

    CPT 19284: Stereotactic Add-On Breast Localization, Additional Lesion

    CPT-19285-BREAST-LESION-LOCALIZATION-ULTRASOUND-GUIDED-FIRST-LESION

    CPT 19285: Ultrasound-Guided Breast Lesion Localization, First Lesion

    CPT-19286-ULTRASOUND-GUIDED-BREAST-LOCALIZATION-ADD-ON

    CPT 19286: Ultrasound-Guided Breast Localization Device Placement

    CPT-19287-MRI-GUIDED-BREAST-LESION-LOCALIZATION

    CPT 19287: MRI-Guided Breast Lesion Localization, First Lesion

    CPT-19288-MRI-GUIDED-ADD-ON-BREAST-LOCALIZATION

    CPT 19288: MRI-Guided Breast Localization, Add-on

    CPT-19296-BALLOON-CATHETER-PLACEMENT-BRACHYTHERAPY-PARTIAL-MASTECTOMY

    CPT 19296: Balloon Catheter Placement for Breast Radiotherapy After Partial Mastectomy

    CPT-19297-BALLOON-CATHETER-PLACEMENT-PARTIAL-MASTECTOMY-RADIOTHERAPY

    CPT 19297: Balloon Catheter Placement for Radiotherapy at Partial Mastectomy

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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