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    v1.0.30
    OpenPayerBilling CodesIntroduction Procedures on the BreastCPT cpt-19285-breast-lesion-localization-ultrasound-guided-first-lesion
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    CPT 19285: Ultrasound-Guided Breast Lesion Localization, First Lesion

    Medicare pays $365 on average nationally for this procedure.

    CPT code 19285 describes ultrasound-guided placement of a device for breast lesion localization (such as a clip, metallic pellet, wire/needle, or radioactive seeds) and is reported for the first lesion; service type: image-guided breast lesion localization; typical site of service: outpatient radiology or breast imaging suite, ambulatory surgery center, or hospital outpatient department.

    For related coverage guidance, see recent payer policy updates: Removal of Implantable, Outpatient Surgical Procedures - Site of Service, Surgical Procedures.

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    Clinical & Coding Specifications

    Clinical Context

    A 54-year-old woman with a suspicious, non-palpable breast lesion identified on diagnostic ultrasound is scheduled for ultrasound-guided localization. The patient previously underwent mammography and targeted ultrasound that demonstrated a 9-mm hypoechoic mass in the left breast. The surgeon requests placement of a localization device (clip or wire) immediately prior to a lumpectomy to assist intraoperative identification. In the outpatient breast imaging suite, a breast radiologist performs real-time ultrasound guidance to insert a localization device (such as a clip, metallic pellet, wire/needle, or radioactive seed) into the lesion. The procedure includes patient positioning, sterile preparation, local anesthesia, device placement with sonographic confirmation of position, and brief post-placement imaging and documentation. The localization is billed using 19285 for the first lesion localized. Typical workflow includes pre-procedure consent and review of images, coordination with breast surgery for operating room timing (if wire or seed), and communication of device type and laterality in the report. Typical site of service is an outpatient imaging center, hospital outpatient department, or ambulatory surgical center.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    19290Placement of localization device(s) (eg, clip, metallic pellet, wire, needle), radiology or other modality, for first lesion when performed under stereotactic guidanceAlternative localization technique using stereotactic guidance rather than ultrasound; used when lesion is mammographically seen and requires stereotactic placement.
    19081Percutaneous needle core biopsy, breast, without localization, first lesion, including imaging guidance and placement of localization device when performedPerformed when tissue diagnosis is obtained; clip placement often occurs at time of biopsy and may be billed with this code when applicable.
    19083Biopsy, percutaneous, needle, with placement of clip, each additional lesionAdditional biopsy with clip placement for multiple lesions; relates when more than one lesion requires marking.
    39330Insertion of radioactive implant; for localization or treatment (note: example radiation code may vary)In settings where radioactive seed localization is used, radioactive device handling and related facility workflow intersect with 19285.
    19120Excision of breast lesion identified by preoperative placement of radiological marker (e.g., wire localization)Surgical excision performed after localization; the localization facilitates intraoperative lesion removal.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    363LF0000X
    207V00000X
    261QA0600X
    207QA0401X
    315D00000X
    252Y00000X
    251C00000X

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Removal of ImplantableBlue Cross Blue Shield - Rhode Island2026-10-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Surgical ProceduresUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Medical Necessity Guidelines Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01

    Related Codes

    CPT-19281-BREAST-LESION-LOCALIZATION-MAMMOGRAPHIC-GUIDANCE

    CPT 19281: Mammographic-Guided Breast Lesion Localization, First Lesion

    CPT-19282-BREAST-LOCALIZATION-DEVICE-PLACEMENT-MAMMOGRAPHIC-GUIDANCE

    CPT 19282: Mammographic-Guided Breast Localization Add-On

    CPT-19283-STEREOTACTIC-BREAST-LESION-LOCALIZATION-FIRST-LESION

    CPT 19283: Stereotactic Breast Lesion Localization, First Lesion

    CPT-19284-STEREOTACTIC-BREAST-LOCALIZATION-ADD-ON

    CPT 19284: Stereotactic Add-On Breast Localization, Additional Lesion

    CPT-19286-ULTRASOUND-GUIDED-BREAST-LOCALIZATION-ADD-ON

    CPT 19286: Ultrasound-Guided Breast Localization Device Placement

    CPT-19287-MRI-GUIDED-BREAST-LESION-LOCALIZATION

    CPT 19287: MRI-Guided Breast Lesion Localization, First Lesion

    CPT-19288-MRI-GUIDED-ADD-ON-BREAST-LOCALIZATION

    CPT 19288: MRI-Guided Breast Localization, Add-on

    CPT-19294-TUMOR-CAVITY-PREPARATION-IORT-PARTIAL-MASTECTOMY

    CPT 19294: Tumor Cavity Preparation for Intraoperative Radiation Therapy

    CPT-19296-BALLOON-CATHETER-PLACEMENT-BRACHYTHERAPY-PARTIAL-MASTECTOMY

    CPT 19296: Balloon Catheter Placement for Breast Radiotherapy After Partial Mastectomy

    CPT-19297-BALLOON-CATHETER-PLACEMENT-PARTIAL-MASTECTOMY-RADIOTHERAPY

    CPT 19297: Balloon Catheter Placement for Radiotherapy at Partial Mastectomy

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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