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    OpenPayerBilling CodesIntroduction Procedures on the BreastCPT cpt-19281-breast-lesion-localization-mammographic-guidance
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    CPT 19281: Mammographic-Guided Breast Lesion Localization, First Lesion

    Medicare pays $244 on average nationally for this procedure.

    CPT code 19281 describes placement of a device for breast lesion localization (such as a clip, metallic pellet, wire, needle, or radioactive seed) performed under mammographic guidance, intended for the first lesion; service type is image-guided localization, and the typical site of service is an outpatient radiology suite or breast imaging center where mammographic localization procedures are performed.

    For related coverage guidance, see recent payer policy updates: Removal of Implantable, Outpatient Surgical Procedures - Site of Service, Surgical Procedures.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old woman with a screening mammogram that identified a 9 mm suspicious spiculated mass in the right breast is scheduled for marker placement under mammographic guidance prior to surgical excision. The patient arrives to the breast imaging suite on the day of localization. The radiology team reviews prior imaging and consent, confirms the target lesion on real-time mammographic views (stereotactic or tomosynthesis guidance), administers local anesthesia, and places a localization device (e.g., clip, metallic pellet, or wire/seed) into the lesion. Post-placement mammographic images document device position relative to the lesion. The patient is discharged to the surgical team for targeted resection later the same day or within days as planned. Typical site of service is an outpatient hospital radiology department or an ambulatory imaging center dedicated to breast procedures.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    19281Placement of localization device(s) for breast lesion, first lesion, mammographic guidancePrimary procedure describing mammographic-guided placement of a clip, pellet, wire, needle, or radioactive seed for the first lesion
    19282Placement of localization device(s) for breast lesion, each additional lesion, mammographic guidanceUsed when more than one lesion in the same operative session requires separate localization
    19083Image-guided needle localization of breast lesion(s) (e.g., for biopsy or surgical guidance), including placement of localization device, radiologic supervision and interpretation; stereotacticMay be used when stereotactic guidance is specifically documented for localization and image guidance services are billed separately
    77046Radiologic guidance for needle placement (e.g., stereotactic), breastDescribes the imaging guidance component that supports the localization procedure when billed separately
    19125Excision of breast lesion identified by preoperative placement of radiological markerSurgical excision typically performed after localization; directly related in the procedural workflow

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    99Modifier 99 is a placeholder modifier used when more modifiers apply to a single procedure than the claim form or electronic field allows. The AMA classifies it under Provider Services and Ambulatory…- Use CPT modifier -99 when more modifiers apply to a single procedure line than the claim form or payer field allows (CMS/Noridian: when more than four modifiers are needed); append modifier 99 on…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    164W00000X
    363LF0000X
    344600000X
    251F00000X
    163WN0003X
    2080S0012X
    283X00000X

    Related ICD-10-CM Codes

    23 rows

    ICD-10-CM CodeDescription
    C50.911Malignant neoplasm of unspecified site of right female breast
    C50.912Malignant neoplasm of unspecified site of left female breast
    C50.919Malignant neoplasm of unspecified site of unspecified female breast
    D05.10Intraductal carcinoma in situ of unspecified breast
    D05.11Intraductal carcinoma in situ of right breast
    D05.12Intraductal carcinoma in situ of left breast
    D24.9Benign neoplasm of unspecified breast
    N60.01Solitary cyst of right breast
    N60.11Diffuse cystic mastopathy of right breast
    N60.12Diffuse cystic mastopathy of left breast

    Showing 1–10 of 23

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Removal of ImplantableBlue Cross Blue Shield - Rhode Island2026-10-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Surgical ProceduresUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Medical Necessity Guidelines Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01

    Related Codes

    CPT-19282-BREAST-LOCALIZATION-DEVICE-PLACEMENT-MAMMOGRAPHIC-GUIDANCE

    CPT 19282: Mammographic-Guided Breast Localization Add-On

    CPT-19283-STEREOTACTIC-BREAST-LESION-LOCALIZATION-FIRST-LESION

    CPT 19283: Stereotactic Breast Lesion Localization, First Lesion

    CPT-19284-STEREOTACTIC-BREAST-LOCALIZATION-ADD-ON

    CPT 19284: Stereotactic Add-On Breast Localization, Additional Lesion

    CPT-19285-BREAST-LESION-LOCALIZATION-ULTRASOUND-GUIDED-FIRST-LESION

    CPT 19285: Ultrasound-Guided Breast Lesion Localization, First Lesion

    CPT-19286-ULTRASOUND-GUIDED-BREAST-LOCALIZATION-ADD-ON

    CPT 19286: Ultrasound-Guided Breast Localization Device Placement

    CPT-19287-MRI-GUIDED-BREAST-LESION-LOCALIZATION

    CPT 19287: MRI-Guided Breast Lesion Localization, First Lesion

    CPT-19288-MRI-GUIDED-ADD-ON-BREAST-LOCALIZATION

    CPT 19288: MRI-Guided Breast Localization, Add-on

    CPT-19294-TUMOR-CAVITY-PREPARATION-IORT-PARTIAL-MASTECTOMY

    CPT 19294: Tumor Cavity Preparation for Intraoperative Radiation Therapy

    CPT-19296-BALLOON-CATHETER-PLACEMENT-BRACHYTHERAPY-PARTIAL-MASTECTOMY

    CPT 19296: Balloon Catheter Placement for Breast Radiotherapy After Partial Mastectomy

    CPT-19297-BALLOON-CATHETER-PLACEMENT-PARTIAL-MASTECTOMY-RADIOTHERAPY

    CPT 19297: Balloon Catheter Placement for Radiotherapy at Partial Mastectomy

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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