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    v1.0.28
    OpenPayerBilling CodesMycosesICD-10-CM b45-cryptococcosis
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    ICD-10-CM Code For Cryptococcosis: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group B45 includes diagnoses for cryptococcal infections such as cryptococcal meningitis, pulmonary cryptococcosis, cutaneous cryptococcosis, and disseminated cryptococcosis, covering both localized and systemic disease presentations. These ICD-10-CM diagnosis codes are used to document clinical scenarios including organ-specific involvement, severity of infection, and presence of dissemination or immunocompromise that affects management and resource use. Accurate coding within the ICD-10-CM B45 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM B45: Cryptococcosis Overview

    The ICD-10-CM B45 code group represents diagnoses for cryptococcal infections caused by Cryptococcus species, affecting the central nervous system, lungs, skin, or disseminated systems. These infections are fungal in origin and can range from localized pulmonary disease to life-threatening meningitis or disseminated infection. Accurate coding is important for reflecting disease severity and organ involvement, which supports appropriate reimbursement and clinical tracking.

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    When to Use

    Use a code from this group when a confirmed diagnosis of cryptococcosis is documented, specifying the anatomical site and whether the infection is disseminated or involves the central nervous system. Choose the most specific code available to reflect severity, organ involvement, and any associated complications.

    ICD-10-CM Codes

    7 rows

    ICD-10-CM CodeDescription
    B45.0Pulmonary cryptococcosis
    B45.1Cerebral cryptococcosis
    B45.2Cutaneous cryptococcosis
    B45.3Osseous cryptococcosis
    B45.7Disseminated cryptococcosis
    B45.8Other forms of cryptococcosis
    B45.9Cryptococcosis, unspecified

    DRG Codes

    13 rows

    DRG CodeDescription
    023Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator
    024Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC
    097Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC
    098Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC
    099Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems
    867Other Infectious and Parasitic Diseases Diagnoses with MCC
    868Other Infectious and Parasitic Diseases Diagnoses with CC
    869Other Infectious and Parasitic Diseases Diagnoses without CC/MCC
    974HIV with Major Related Condition with MCC
    975HIV with Major Related Condition with CC
    976HIV with Major Related Condition without CC/MCC

    Typical Clinical Scenarios

    • An HIV-positive adult with progressive headache, fever, neck stiffness, and confusion presents to the emergency department; lumbar puncture shows encapsulated yeast on India ink, elevated opening pressure, and positive cryptococcal antigen in cerebrospinal fluid. Because this is a central nervous system infection with evidence of meningitis, a code reflecting cryptococcal meningoencephalitis is assigned. Typical codes: B45.1
    • A middle-aged patient on chronic corticosteroid therapy for autoimmune disease develops slowly progressive pulmonary symptoms including cough, weight loss, and new pulmonary nodules on imaging; sputum culture grows Cryptococcus species. This scenario represents a localized pulmonary cryptococcal infection confirmed microbiologically, so a pulmonary cryptococcosis code is used. Typical codes: B45.0
    • A hospitalized patient with disseminated cryptococcal infection identified by positive blood cultures and multiple organ involvement (skin papules and focal neurologic deficits) who also has septic physiology; the clinical circumstance is a systemic, disseminated mycosis requiring inpatient management, and a code for disseminated cryptococcosis is assigned. Typical codes: B45.7, B45.9

    Related Codes

    B35-DERMATOPHYTOSIS

    ICD-10-CM Code For Dermatophytosis: Group Overview

    B36-OTHER-SUPERFICIAL-MYCOSES

    ICD-10-CM Code For Other Superficial Mycoses: Group Overview

    B37-CANDIDIASIS

    ICD-10-CM Code For Candidiasis: Group Overview

    B38-COCCIDIOIDOMYCOSIS

    ICD-10-CM Code For Coccidioidomycosis: Group Overview

    B39-HISTOPLASMOSIS

    ICD-10-CM Code For Histoplasmosis: Group Overview

    B41-PARACOCCIDIOIDOMYCOSIS

    ICD-10-CM Code For Paracoccidioidomycosis: Group Overview

    B42-SPOROTRICHOSIS-INFECTION

    ICD-10-CM Code For Sporotrichosis: Group Overview

    B43-CHROMOMYCOSIS-AND-PHEOMYCOTIC-ABSCESS

    ICD-10-CM Code For Chromomycosis And Pheomycotic Abscess: Group Overview

    B44-ASPERGILLOSIS

    ICD-10-CM Code For Aspergillosis: Group Overview

    B46-ZYGOMYCOSIS

    ICD-10-CM Code For Zygomycosis: Group Overview

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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