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    v1.0.28
    OpenPayerBilling CodesOther viral diseasesICD-10-CM b25-cytomegaloviral-disease
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    ICD-10-CM Code For Cytomegaloviral Disease: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group B25 includes cytomegaloviral disease codes describing systemic and organ-specific cytomegalovirus infections such as pneumonitis, hepatitis, retinitis, and other tissue-invasive manifestations. These ICD-10-CM diagnosis codes are used to document the presence, severity, and organ involvement of cytomegaloviral infection, capturing clinical complexity and complications. Accurate coding within the ICD-10-CM B25 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM B25: Cytomegaloviral Disease Overview

    The ICD-10-CM B25 code group represents cytomegaloviral infections caused by cytomegalovirus affecting various organ systems. These diagnoses target systemic and organ-specific manifestations such as pneumonitis, hepatitis, retinitis, and other tissue-invasive disease. Accurate coding is important for reflecting clinical severity and organ involvement, which supports appropriate claim adjudication and documentation for patient care.

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    When to Use

    Use a code from this group when cytomegalovirus is identified as the cause of symptomatic disease or tissue-invasive infection documented in the medical record. Select the specific B25 code that corresponds to the organ system affected and the documented clinical manifestation.

    ICD-10-CM Codes

    5 rows

    ICD-10-CM CodeDescription
    B25.0Cytomegaloviral pneumonitis
    B25.1Cytomegaloviral hepatitis
    B25.2Cytomegaloviral pancreatitis
    B25.8Other cytomegaloviral diseases
    B25.9Cytomegaloviral disease, unspecified

    DRG Codes

    16 rows

    DRG CodeDescription
    177Respiratory Infections and Inflammations with MCC
    178Respiratory Infections and Inflammations with CC
    179Respiratory Infections and Inflammations without CC/MCC
    438Disorders of Pancreas Except Malignancy with MCC
    439Disorders of Pancreas Except Malignancy with CC
    440Disorders of Pancreas Except Malignancy without CC/MCC
    441Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis with MCC
    442Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis with CC
    443Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis without CC/MCC
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems
    865Viral Illness with MCC
    866Viral Illness without MCC
    974HIV with Major Related Condition with MCC
    975HIV with Major Related Condition with CC
    976HIV with Major Related Condition without CC/MCC

    Typical Clinical Scenarios

    • An infant born to a mother with known primary cytomegalovirus infection presents with petechial rash, hepatosplenomegaly, jaundice, and sensorineural hearing concern on newborn screening. The neonate is evaluated in the nursery with targeted labs (CMV PCR, liver panel) and imaging; a confirmed congenital viral infection explains the systemic findings and organ involvement, prompting assignment of a code for cytomegaloviral disease presenting in a newborn. Typical codes: B25.1
    • An adult patient with advanced HIV infection is admitted with fever, malaise, and progressively worsening visual blurring; ophthalmologic exam reveals necrotizing retinitis consistent with CMV ocular disease. Hospital workup including CMV PCR and retinal imaging supports active cytomegaloviral infection causing end-organ disease, so a code for CMV disease affecting the eye is recorded. Typical codes: B25.2
    • A hospitalized transplant recipient on immunosuppressive therapy develops fever, hepatitis with markedly elevated transaminases, and positive CMV PCR in blood without focal organ-specific manifestations. The clinician documents systemic CMV disease as the cause of the febrile hepatitis and viremia in the immunocompromised host, leading to assignment of a general cytomegaloviral disease code when organ-specific code is not used. Typical codes: B25.9, B25.8

    Related Codes

    B26-MUMPS

    ICD-10-CM Code For Mumps: Group Overview

    B27-INFECTIOUS-MONONUCLEOSIS

    ICD-10-CM Code For Infectious Mononucleosis: Group Overview

    B30-VIRAL-CONJUNCTIVITIS

    ICD-10-CM Code For Viral Conjunctivitis: Group Overview

    B33-OTHER-VIRAL-DISEASES-NOT-ELSEWHERE-CLASSIFIED

    ICD-10-CM Code For Other Viral Diseases Not Elsewhere Classified: Group Overview

    B34-VIRAL-INFECTION-OF-UNSPECIFIED-SITE

    ICD-10-CM Code For Viral Infection Of Unspecified Site: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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