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    v1.0.28
    OpenPayerBilling CodesOther viral diseasesICD-10-CM b27-infectious-mononucleosis
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    ICD-10-CM Code For Infectious Mononucleosis: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group B27 includes infectious mononucleosis diagnoses caused by Epstein-Barr virus and related viral agents, capturing presentations such as acute infectious mononucleosis and complications like hepatitis or splenic enlargement. These ICD-10-CM diagnosis codes are used to document clinical scenarios including acute symptomatic infection, organ-specific complications, and prolonged convalescence that affect management and resource use. Accurate coding within the ICD-10-CM B27 group supports proper claim adjudication and complete clinical documentation for appropriate reimbursement.

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    ICD-10-CM B27: Infectious Mononucleosis Overview

    The ICD-10-CM B27 group includes infectious mononucleosis diagnoses caused by Epstein-Barr virus and related viral agents affecting the lymphoreticular and oropharyngeal systems. These conditions primarily involve systemic viral infection with symptoms such as fever, sore throat, lymphadenopathy, and fatigue. Accurate coding matters for appropriate claim processing and to reflect clinical complexity for reimbursement.

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    When to Use

    Use a code from this group when a patient is diagnosed with infectious mononucleosis confirmed by clinical evaluation or laboratory testing and when documentation specifies related complications or organ involvement. Select codes that reflect the specific viral cause and any documented complications to ensure accurate clinical and billing records.

    ICD-10-CM Codes

    16 rows

    ICD-10-CM CodeDescription
    B27.00Gammaherpesviral mononucleosis without complication
    B27.01Gammaherpesviral mononucleosis with polyneuropathy
    B27.02Gammaherpesviral mononucleosis with meningitis
    B27.09Gammaherpesviral mononucleosis with other complications
    B27.10Cytomegaloviral mononucleosis without complications
    B27.11Cytomegaloviral mononucleosis with polyneuropathy
    B27.12Cytomegaloviral mononucleosis with meningitis
    B27.19Cytomegaloviral mononucleosis with other complication
    B27.80Other infectious mononucleosis without complication
    B27.81Other infectious mononucleosis with polyneuropathy
    B27.82Other infectious mononucleosis with meningitis
    B27.89Other infectious mononucleosis with other complication
    B27.90Infectious mononucleosis, unspecified without complication
    B27.91Infectious mononucleosis, unspecified with polyneuropathy
    B27.92Infectious mononucleosis, unspecified with meningitis
    B27.99Infectious mononucleosis, unspecified with other complication

    DRG Codes

    2 rows

    DRG CodeDescription
    865Viral Illness with MCC
    866Viral Illness without MCC

    Typical Clinical Scenarios

    • A previously healthy teenager presents to urgent care with 2 weeks of fever, severe sore throat, tender anterior and posterior cervical lymphadenopathy, marked fatigue limiting school attendance, and splenomegaly on exam. Heterophile antibody testing (Monospot) is positive and supportive care is recommended; an acute primary infection due to Epstein–Barr virus is diagnosed. Typical codes: B27.00, B27.01.
    • An adult patient with a history of infectious mononucleosis months ago returns with persistent fatigue, intermittent low-grade fever, and prolonged cervical lymph node enlargement despite resolution of acute pharyngitis. The clinician documents convalescent or prolonged course following viral mononucleosis requiring follow-up and symptomatic management. Typical codes: B27.10, B27.11.
    • A college athlete presents to the emergency department with acute-onset high fever, severe sore throat, and abdominal pain after a recent diagnosis of infectious mononucleosis; imaging confirms splenic enlargement and concern for splenic rupture is evaluated. The visit documents complications or sequelae of the viral infection requiring urgent assessment and possible surgical consultation. Typical codes: B27.80, B27.81.

    Related Codes

    B25-CYTOMEGALOVIRAL-DISEASE

    ICD-10-CM Code For Cytomegaloviral Disease: Group Overview

    B26-MUMPS

    ICD-10-CM Code For Mumps: Group Overview

    B30-VIRAL-CONJUNCTIVITIS

    ICD-10-CM Code For Viral Conjunctivitis: Group Overview

    B33-OTHER-VIRAL-DISEASES-NOT-ELSEWHERE-CLASSIFIED

    ICD-10-CM Code For Other Viral Diseases Not Elsewhere Classified: Group Overview

    B34-VIRAL-INFECTION-OF-UNSPECIFIED-SITE

    ICD-10-CM Code For Viral Infection Of Unspecified Site: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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