Loading...

    Explore
    • Policy Monitoring
    • Live Policy Feed
    • Billing Codes
    • Healthcare Providers
    • Health Insurance Payers
    • States
    • Service Lines
    • Taxonomy Codes
    Lookup tools
    • Billing Code Lookup
    • CPT Modifier Lookup
    • Provider Taxonomy Code Lookup
    • Healthcare Provider & Facility Lookup
    • Health Insurance Payer Lookup
    • Payer Contact Directory

    Policy & Benchmark Tools

    • Prior Authorization Lookup
    • Coverage Criteria Lookup
    • Timely Filing Lookup
    • Billing Code Reimbursement Rates
    • Payer Comparison Dashboard
    • Facility Comparison Dashboard
    • All tools

    Company

    • About OpenPayer
    • Data Sources
    • Trek Health
    OpenPayerby Trek Health
    LinkedInYouTube

    © 2026 Trek Health. All rights reserved.

    OpenPayer is built and maintained by Trek Health.

    v1.0.31
    OpenPayerPolicy UpdatesGeneral SurgeryCurative APR Inpatient Coverage Policy | OpenPayer
    Ask Trek AI about this page

    OpenPayer is powered by Trek Health's payer performance platform. Trek continuously ingests, validates, and normalizes Transparency in Coverage data alongside payer policies and other commercial payer data to create a structured payer intelligence foundation. OpenPayer uses this foundation to deliver personalized search results, dynamically generated policy pages, and tailored policy monitoring based on each user's payers, specialties, billing codes, and areas of interest. The same intelligence powers broader payer performance workflows, including reimbursement benchmarking, contract evaluation, payer negotiations, and financial decision-making.

    CurrentCurativePolicy CHP-IP-2026-147

    Abdominoperineal Resection (APR)

    Customize your policy alerts

    Sign up for curative Policy CHP-IP-2026-147 alerts

    Get alerted when Policy CHP-IP-2026-147 changes without checking for updates manually.

    Monitor payer policy activity

    Receive email alerts as soon as relevant payer policies are published or updated.

    This policy governs medical necessity, inpatient level of care, continued stay, discharge readiness, and documentation for open, laparoscopic, or robotic abdominoperineal resection with permanent end colostomy and perineal closure or flap reconstruction in adults 18 years and older.

    Policy Summary
    PayerCurative
    PolicyAbdominoperineal Resection (APR)
    Policy CodePolicy CHP-IP-2026-147
    Change TypeAdministrative version update
    Effective DateN/A
    Next Review DateN/A
    Key ActionSubmit the operative plan, perioperative risk information, and operative note to support authorization.
    SourceLink
    POLICY UPDATE CHANGES

    No material clinical or coverage changes in this revision.

    Adults 18+Applicable population
    4-7 daysExpected uncomplicated stay
    6-9 daysStay with flap reconstruction
    NEWS2 ≥7ICU assessment threshold
    28 daysCancer VTE prophylaxis

    Medical Necessity and Level-of-Care Criteria

    Initial inpatient admission

    Acute inpatient admission for abdominoperineal resection is medically necessary when ALL of the following are met.

    APR inpatient medical necessity

    • Procedure indication

      • Low rectal adenocarcinoma: Tumor involves the anal sphincter complex or levators, or sphincter-preserving resection cannot achieve clear margins or acceptable function, supported by pelvic MRI and applicable rectal cancer guidance.
      • Persistent or recurrent anal squamous cell carcinoma: Biopsy-proven persistent disease, generally assessed up to approximately 26 weeks after chemoradiation, or local recurrence.Up to approximately 26 weeks after chemoradiation for response assessment
    Policy Summary
    PayerCurative
    PolicyAbdominoperineal Resection (APR)
    Policy CodePolicy CHP-IP-2026-147
    Change TypeAdministrative version update
    Effective DateN/A
    Next Review DateN/A
    Key ActionSubmit the operative plan, perioperative risk information, and operative note to support authorization.
    SourceLink
    On This Page
    Medical Necessity and Level-of-Care CriteriaCoding and Utilization ReferenceAuthorization and Documentation RequirementsProcedure BackgroundPolicy Definitions
    Severe benign disease is not amenable to sphincter preservation, such as refractory Crohn perianal disease or radiation injury with fecal incontinence and fistula.
  1. Inpatient setting required

    • APR postoperative requirement: APR requires inpatient postoperative care because of pelvic dissection, the perineal wound, and creation of a new colostomy.
    • Elevated perioperative risk: ASA physical status III or higher, or documented frailty, with anticipated postoperative physiologic monitoring beyond observation capability.ASA III or higher
    • Significant comorbidity: Comorbidity requires inpatient perioperative management, including heart failure with LVEF 40% or less or NYHA class III-IV symptoms; insulin-treated diabetes requiring intravenous insulin or frequent titration; obstructive sleep apnea requiring parenteral opioids and continuous oximetry; CKD stage 4-5 or dialysis; or therapeutic anticoagulation requiring bridging.LVEF ≤40% or NYHA III-IV; CKD stage 4-5 or dialysis
    • Intraoperative change in expected course: Blood loss requiring transfusion, conversion to an open approach, unplanned additional organ resection, or a difficult airway changes the expected course.
  2. Observation or outpatient evaluation

    Observation or outpatient care is appropriate only for the related evaluation procedures below.

    Related evaluation procedure: Examination under anesthesia and biopsy to confirm persistent or recurrent disease are ordinarily performed on an outpatient basis.

    No observation pathway applies to APR itself.

    Intensive care unit

    ICU care is appropriate when ANY of the following is documented.

    ICU criteria

    • Major surgical complication: Anastomotic leak with sepsis, planned relook laparotomy, or open abdomen.
    • Shock or vasoactive support: Vasopressor or inotrope infusion is required to maintain mean arterial pressure of at least 65 mmHg, or septic shock is present.MAP ≥65 mmHg; septic shock: lactate >2 mmol/L despite adequate fluid resuscitation
    • Severe respiratory failure: Invasive mechanical ventilation or escalating noninvasive support is required for acute respiratory failure.SpO2 <90% despite FiO2 ≥0.6, or pH <7.25 with rising PaCO2
    • Unstable hemorrhage: Active hemorrhage causes hemodynamic instability or activates a massive transfusion protocol, with return to the operating room or angioembolization pending.
    • Persistent high NEWS2: NEWS2 of 7 or higher persists after initial treatment and the physician documents a need for organ support or continuous one-to-one monitoring.NEWS2 ≥7

    Step-down or intermediate care

    Step-down or intermediate care is appropriate when ANY of the following is documented and no ICU criterion is present.

    Step-down criteria

    • Flap or epidural monitoring: A myocutaneous flap requires hourly checks, or epidural analgesia causes hypotension after pelvic dissection.Hourly flap checks
    • Intermediate NEWS2: NEWS2 of 5-6 or a single parameter score of 3 requires vital signs at least every 1-2 hours without organ-support need.NEWS2 5-6 or single parameter score 3
    • Significant arrhythmia: A new or hemodynamically significant arrhythmia requires continuous cardiac monitoring and rate-control titration.
    • Stable respiratory or opioid monitoring need: Noninvasive ventilation or high-flow nasal oxygen is required in an otherwise stable patient, or obstructive sleep apnea with parenteral opioids requires continuous pulse oximetry and capnography.

    Medical-surgical unit

    Medical-surgical unit care is appropriate when ANY of the following applies.

    Medical-surgical criteria

    • Routine postoperative care: Colostomy teaching, perineal wound care, positioning restrictions after flap, and mobilization are required.
    • Stable hospital-level treatment: The patient is hemodynamically stable with NEWS2 of 0-4 and requires parenteral or epidural analgesia, intravenous fluids or antibiotics, drain or wound management, or monitored diet advancement.NEWS2 0-4
    • Routine vital-sign monitoring: Vital signs every 4 hours are adequate and no ICU or step-down criterion is present.Every 4 hours

    Discharge readiness

    The patient is ready for discharge from acute care when ALL of the following are met.

    • Temperature is below 38.0 C for at least 24 hours, or a fever source is identified with an oral or outpatient treatment plan.<38.0 C for ≥24 hours
    • Stable vital signs: Vital signs are stable on room air or the baseline home oxygen requirement.NEWS2 0-4 for 12-24 hours
    • Pain control: Pain is controlled on oral analgesics with an opioid-sparing discharge regimen documented.
    • Nutrition: Oral fluids and diet are tolerated, or an enteral or parenteral nutrition plan is arranged.
    • Laboratory stability: Hemoglobin is stable without transfusion, and creatinine and electrolytes are at or near baseline or have a follow-up plan.No transfusion for ≥24 hours
    • Mobility and transition: Mobility is at the expected post-procedure level or safe transfer to documented post-acute care is arranged; medication reconciliation, VTE prophylaxis, wound and drain instructions, return precautions, and follow-up are documented.
    • Bowel and stoma function: Flatus or stool has returned; a regular or soft diet is tolerated without vomiting; the colostomy is functioning with self-care demonstrated or home health arranged; and the perineal wound is intact or has a wound-care plan.
    • Cancer VTE prophylaxis: Extended venous thromboembolism prophylaxis is arranged after cancer resection.28 days

    Continued acute inpatient stay

    Continued acute inpatient stay is medically necessary when ANY of the following is documented at each review.

    Continued-stay criteria

    • High-acuity care: Any ICU or step-down level-of-care criterion is present, or NEWS2 is 5 or higher.NEWS2 ≥5
    • Non-lower-level IV treatment: Intravenous therapy cannot be provided at a lower level of care, such as IV antibiotics without an oral or outpatient infusion option, initiation of parenteral nutrition, or IV analgesia.
    • Intake or ileus problem: The patient cannot tolerate oral intake, or ileus requires nasogastric decompression.
    • Pending acute intervention: An urgent procedure, imaging study, or consultation expected within 24 hours is pending and could change acute management.Within 24 hours
    • Pelvic or anastomotic complication: Anastomotic leak, pelvic abscess, or fistula requires image-guided drainage, IV antibiotics, or reoperation.
    • Obstruction or ileus: Ileus or small-bowel obstruction requires nasogastric decompression or parenteral nutrition.
    • Stoma-related metabolic complication: High-output ileostomy with acute kidney injury or electrolyte derangement requires IV replacement.
    • Wound complication: A perineal or abdominal wound complication requires inpatient debridement or IV antibiotics.
    • Flap compromise or dehiscence: Perineal flap compromise or wound dehiscence requires initiation of negative-pressure therapy or operative revision.

    Extended-stay review

    Days beyond the expected benchmark are supported when ANY extended-stay trigger is documented with clinical evidence and an active treatment plan.

    Extended-stay triggers

    • Perineal wound infection or dehiscence: Active perineal wound infection or dehiscence is documented.
    • Flap compromise: Myocutaneous flap compromise is documented.
    • Ileus is documented and requires ongoing acute management.
    • Urinary or ureteral complication: Urinary retention or ureteral injury is documented.
    • Pelvic abscess is documented with an active treatment plan.

    Preoperative admission more than one day before surgery for scheduling, travel, or convenience is excluded from medical necessity unless a documented medical reason supports the additional inpatient time. Preoperative evaluation and preparation can generally be completed on an outpatient basis.

    Custodial, respite, or convenience days do not meet medical necessity for acute inpatient care. These days should be referred for physician review rather than supported as acute-level hospitalization.

    Abdominoperineal resection for anal squamous cell carcinoma is not medically necessary before completion of chemoradiation and the response-assessment period when there is no documented progression. Chemoradiation is the primary treatment, and tumor regression may continue for approximately 26 weeks; such requests require physician review.

    Continued inpatient stay after all discharge-readiness criteria are met is not acute-level care. This includes days spent awaiting post-acute placement, transportation, or equipment when no acute medical need remains. The case should be referred to discharge planning and physician review; days already authorized are not reversed retroactively.

    Coding and Utilization Reference

    ICD-10-CM rectal and anal malignancyICD-10
    C20Malignant neoplasm of rectum
    C21.0Malignant neoplasm of anus, unspecified
    C21.1Malignant neoplasm of anal canal
    C21.2Malignant neoplasm of cloacogenic zone
    C21.8Malignant neoplasm of overlapping sites of rectum, anus and anal canal
    ICD-10-PCS rectal and anal resectionICD-10
    0DTP0ZZResection of rectum, open approach
    0DTQ0ZZResection of anus, open approach
    0DTP4ZZResection of rectum, percutaneous endoscopic approach
    0DTQ4ZZResection of anus, percutaneous endoscopic approach
    CPT abdominoperineal proctectomyCPT
    45110Abdominoperineal proctectomy, open
    45395Abdominoperineal proctectomy, laparoscopic
    MS-DRG FY2027 v44Revenue
    332Rectal resection with MCC
    333Rectal resection with CC
    334Rectal resection without CC/MCC
    Facility revenue codesRevenue
    0120Facility revenue code
    0121Facility revenue code
    0200Facility revenue code
    0206Facility revenue code
    0270Facility revenue code
    0360Facility revenue code
    0370Facility revenue code
    0710Facility revenue code
    0762Facility revenue code
    NEWS2 ICU threshold
    NEWS2 threshold7 or higher
    PersistencePersists after initial treatment
    Required supportDocumented need for organ support or continuous one-to-one monitoring
    Septic shock
    Vasopressor criterionVasopressor requirement
    Lactate criterionLactate above 2 mmol/L
    Resuscitation statusDespite adequate fluid resuscitation
    Acute respiratory failure
    Oxygenation criterionSpO2 below 90% despite FiO2 of 0.6 or higher
    Acid-base criterionpH below 7.25 with rising PaCO2
    Respiratory supportInvasive mechanical ventilation or escalating noninvasive support
    NEWS2 step-down threshold
    NEWS2 range5-6
    Single-parameter thresholdA single parameter score of 3
    Monitoring requirementVital signs at least every 1-2 hours without need for organ support
    Stable medical-surgical acuity
    NEWS2 range0-4
    Higher-acuity criteriaNo criterion for ICU or step-down care is present
    Monitoring levelVital signs every 4 hours are adequate
    Expected stay
    Uncomplicated course4-7 days
    Myocutaneous flap reconstruction6-9 days
    Use of benchmarkPlanning benchmark for concurrent review, not a limit on covered days
    CMS FY2027 geometric mean LOS
    MS-DRG 332Rectal resection with MCC: 5.8 days
    MS-DRG 333Rectal resection with CC: 3.3 days
    MS-DRG 334Rectal resection without CC/MCC: 2.2 days

    Authorization and Documentation Requirements

    Prior Authorization

    APR Medical-Necessity Authorization

    Request acute inpatient admission for abdominoperineal resection (APR) when an eligible indication is documented and the inpatient setting is medically necessary. APR requires inpatient postoperative care because of pelvic dissection, perineal wound management, and creation of a new colostomy; inpatient need may also be supported by ASA III or higher, frailty, significant comorbidity requiring inpatient management, or an intraoperative event that changes the expected course.

    • Eligible indications include low rectal adenocarcinoma involving the anal sphincter complex or levators, or inability to achieve clear margins or acceptable function with sphincter-preserving resection.
    • Eligible indications also include biopsy-proven persistent anal squamous cell carcinoma generally assessed up to 26 weeks after chemoradiation, local recurrence, or severe benign disease not amenable to sphincter preservation.
    • Document relevant inpatient factors, including heart failure with LVEF ≤40% or NYHA III-IV symptoms, insulin-treated diabetes requiring intravenous insulin or frequent titration, obstructive sleep apnea requiring parenteral opioids and continuous oximetry, CKD stage 4-5 or dialysis, therapeutic-anticoagulation bridging, transfusion, conversion to open surgery, unplanned additional organ resection, or difficult airway.
    Prior Authorization

    Level-of-Care Authorization

    Assign and authorize the level of care that matches the documented acuity. ICU, step-down/intermediate, and medical-surgical placement require objective clinical findings and physician documentation; step-down criteria apply only when no ICU criterion is present.

    • ICU: anastomotic leak with sepsis, planned relook laparotomy or open abdomen; vasopressor/inotrope support to maintain MAP ≥65 mmHg or septic shock; invasive ventilation or escalating noninvasive support for acute respiratory failure; active hemorrhage with instability or massive-transfusion activation; or persistent NEWS2 ≥7 requiring organ support or continuous one-to-one monitoring.
    • Step-down/intermediate: myocutaneous flap requiring hourly checks; epidural-related hypotension; NEWS2 5-6 or a single parameter score of 3 requiring vital signs every 1-2 hours; new hemodynamically significant arrhythmia requiring continuous monitoring and titration; stable noninvasive ventilation/high-flow oxygen; or obstructive sleep apnea requiring parenteral opioids with continuous pulse oximetry and capnography.
    • Medical-surgical: postoperative colostomy teaching, perineal wound care, flap-related positioning restrictions, and mobilization; stable NEWS2 0-4 with ongoing hospital-level analgesia, fluids, antibiotics, drain/wound care, or diet advancement; or need for four-hour vital signs without ICU or step-down criteria.
    Documentation Required

    Continued-Stay Authorization

    Submit documentation supporting each continued acute inpatient day. Continued stay is medically necessary when at least one acute need remains documented at each review, with active treatment and the reason a lower level of care is insufficient.

    • Any ICU or step-down criterion, or NEWS2 ≥5.
    • Intravenous therapy unavailable at a lower level of care; inability to tolerate oral intake; ileus requiring nasogastric decompression; or parenteral nutrition initiation.
    • Urgent procedure, imaging, or consultation expected within 24 hours that may change acute management.
    • Anastomotic leak, pelvic abscess, fistula, ileus, small-bowel obstruction, high-output ileostomy with acute kidney injury/electrolyte derangement, or wound/flap complication requiring inpatient treatment, drainage, intravenous therapy, negative-pressure therapy initiation, or operative revision.
    • Review at least daily in ICU or step-down care and at least every 48 hours on the medical-surgical unit; also review when a red flag occurs or the expected-length-of-stay benchmark is reached. The uncomplicated benchmark is 4-7 days, or 6-9 days with myocutaneous flap reconstruction, and is not a limit on covered days.
    Documentation Required

    Procedure and Perioperative Record

    Include the procedure and perioperative record needed to establish the indication, operative risk, approach, and changes in the expected course.

    • Operative or procedure plan specifying the indication, staging or classification, and approach: open, laparoscopic, or robotic.
    • ASA physical status, relevant comorbidities, and anesthesia risk assessment.
    • Operative note with estimated blood loss, transfusion, intraoperative events, and drains or devices placed.
    Documentation Required

    Concurrent Review and Acuity Documentation

    Support concurrent review with daily clinical and treatment documentation that establishes current acuity, response, and the specific reason acute inpatient care remains necessary.

    • Daily progress notes with vital signs or NEWS2, intake and output, drain output, laboratory trends, active treatment, response to treatment, and the specific reason acute care is still needed.
    • Document the assigned level of care and the objective finding supporting ICU or step-down placement when used.
    • Record clinically relevant changes, escalation or de-escalation of monitoring and treatment, and any red flag prompting reassessment.
    Documentation Required

    Discharge and Surgical Transition Plan

    Document discharge readiness and the surgical transition plan before discharge, including the services, education, and post-acute arrangements needed for a safe transition.

    • Discharge readiness assessment and transition plan, including post-acute referral when applicable.
    • Stoma marking and plan for perineal closure.
    • Colostomy teaching, wound and flap-care instructions, mobility or positioning restrictions, follow-up, and equipment or transportation planning when applicable.
    Documentation Required

    Disease-Specific Supporting Records

    Provide disease-specific records supporting the APR indication, treatment timing, and anatomic or pathologic findings.

    • Pelvic MRI documenting the relationship of the tumor to the sphincters and levators.
    • Biopsy confirming persistent or recurrent anal carcinoma, including timing after chemoradiation when applicable.
    • Relevant oncologic staging, chemoradiation history, response assessment, recurrence documentation, and related clinical records.
    Documentation Required

    Support the Requested Amount

    Ensure the requested quantity, units, and duration are supported by the clinical documentation and active treatment plan.

    • Document the number of inpatient days, level-of-care days, services, units, or other requested increments.
    • If only part of the request is supported, the supported portion may be approved and only the unsupported increment is referred for review.
    Denial Risk

    Premature Salvage APR

    APR for anal squamous cell carcinoma before completion of chemoradiation and the response-assessment period, without progression, does not meet medical-necessity criteria for automatic approval.

    • Chemoradiation is the primary treatment, and regression can continue for up to approximately 26 weeks.
    • Refer the request for physician review; do not issue an automated or non-physician adverse determination.
    Denial Risk

    Unnecessary Preoperative Days

    Preoperative admission more than one day before surgery is not medically necessary when used for scheduling, travel, or convenience without a documented medical reason.

    • Preoperative evaluation and preparation can generally be completed as an outpatient.
    • Refer for physician review when a medical reason for the additional preoperative days is not documented.
    Denial Risk

    Stay After Discharge Readiness

    Continued inpatient days after all discharge-readiness criteria are met do not meet acute inpatient medical-necessity criteria when the patient is only awaiting placement, transportation, or equipment without an acute need.

    • Direct the case to discharge planning and physician review.
    • Days already authorized are not reversed retroactively.
    Denial Risk

    Custodial or Convenience Days

    Custodial, respite, or convenience days are not medically necessary at the acute inpatient level.

    • Refer for physician review rather than issuing an adverse determination through an automated system or non-physician review.
    • Document any acute medical need if continued inpatient care is requested.
    Denial Risk

    Postoperative Red Flags

    Immediately escalate postoperative findings that may indicate wound or flap failure, stoma ischemia, sepsis, hemodynamic or respiratory deterioration, thromboembolism, or another unsafe condition.

    • Perineal wound purulence, flap discoloration, or wound separation: obtain surgical evaluation, consider imaging for pelvic abscess, and initiate antibiotics or debridement as indicated.
    • Dusky or retracted colostomy: obtain urgent bedside assessment of stoma viability and surgical revision if ischemic.
    • NEWS2 ≥7, new systolic blood pressure <90 mmHg, or new oxygen requirement >6 L/min: activate rapid response or emergency evaluation and reassess for ICU transfer.
    • Suspected sepsis, including new organ dysfunction with suspected infection or lactate >2 mmol/L: obtain urgent physician evaluation, cultures, antibiotics, and source-control imaging; transfer to ICU if vasopressors are needed.
    • Signs of pulmonary embolism or deep-vein thrombosis, including unexplained tachycardia, hypoxemia, pleuritic pain, or unilateral leg findings: obtain urgent imaging and make an anticoagulation decision; discharge is unsafe until evaluated.
    Documentation Required

    Criteria Not Met

    Requests that do not satisfy the stated criteria must be referred for physician review. Automated systems and non-physician clinical reviewers may approve in full or in part but may not issue an adverse determination.

    • Only a licensed physician of the same or similar specialty may issue an adverse determination after offering the requesting provider a peer-to-peer discussion and meeting applicable licensure, specialty, and medical-director requirements.
    • The absence of a criterion addressing a service is not itself a basis for an adverse determination; the physician applies generally accepted standards of medical practice.
    • Concurrent review applies to each continued-stay period. Days already authorized are not retroactively denied, and expected length of stay is a planning benchmark, not a limit on covered days.
    Documentation Required

    Requested Amount Exceeds Documentation

    When the requested quantity, units, or duration exceed what the documentation supports, separate the supported portion from the unsupported increment.

    • Approve the supported portion when criteria are met.
    • Refer only the excess quantity, units, or duration for physician review; do not treat the entire request as unsupported solely because an increment exceeds the documentation.

    Procedure Background

    APR may be performed through an open, laparoscopic, or robotic approach. The perineal wound may be closed primarily or reconstructed with a myocutaneous flap, particularly when pelvic radiation or other factors increase the risk of wound complications. Perineal wound complications are a major cause of prolonged hospitalization and readmission.

    Policy Definitions

    Clinical severity findings
    Examination findingsObjective, documented examination findings may establish acuity
    Physiologic findingsVital-sign and laboratory findings may establish acuity
    Other supporting findingsImaging or validated-score findings may establish acuity
    Hospital-level services required
    Setting limitationServices cannot be delivered safely in observation, ambulatory, home, or post-acute settings
    Intravenous therapyFrequent titration of intravenous therapy may require hospital-level services
    Monitoring or proceduresContinuous monitoring or procedures with significant early complication risk may require hospital-level services
    Expected length of stay
    PurposePlanning benchmark for an uncomplicated course
    ReferenceCMS FY2027 MS-DRG geometric mean length of stay
    Coverage interpretationNot a limit on covered days
    NEWS2
    Score componentsRespiratory rate, oxygen saturation, supplemental oxygen, systolic blood pressure, heart rate, level of consciousness, and temperature
    Urgent reviewA score of 5-6 or a single parameter score of 3 prompts urgent review
    Emergency responseA score of 7 or more prompts emergency response
    ASA physical status
    ClassificationAmerican Society of Anesthesiologists classification of preoperative comorbidity
    ASA class IIISevere systemic disease
    ASA class IVSevere systemic disease that is a constant threat to life