Preferred Products Guidelines — Injectable Oncology Medications
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Defines Aloha Care's preferred and non-preferred injectable oncology medications (including radiopharmaceuticals) covered under the medical benefit and the criteria for when non-preferred products are medically necessary; applies to Aloha Care members subject to their benefits.
No material clinical or coverage changes in this revision.
Coverage Criteria for Injectable Oncology Products
Coverage for preferred and non-preferred products
Coverage is provided as follows:
See Diagnosis -Specific Criteria; preferred products are listed in the Preferred Oncology products tables.
Physician attestation and documentation of prior intolerance/contraindication required.
Preferred products for oncology indications
Covered for oncology indications as indicated in the list
See the Preferred Oncology products tables for specific drug-to-code mappings.
Preferred products — oncology indications
Covered when drug and code match payer's preferred list for oncology indications
No additional clinical criteria are specified in these list entries; clinical eligibility follows Diagnosis -Specific Criteria and NCCN guidance.
Preferred designation (informational)
Preferred status and indication scope when stated
This block is informational; refer to product tables for code mappings.
Preferred products (general coverage)
Preferred products are listed with coverage designation in this excerpt
These entries represent the payer's formulary/preferred product roster rather than discrete medical-necessity criteria.
Preferred-product coverage
Covered when product is one of the listed preferred agents for oncology indications
Many entries are noted as 'All oncology indications'; clinical appropriateness is determined by Diagnosis -Specific Criteria and NCCN compendia alignment.
Preferred product listing
Preferred products for oncology:
This is a formulary/preferred product listing rather than indication-specific medical necessity criteria.
Preferred product lists
Preferred products for oncology-administered injectable agents
Providers should reference the listed code for the preferred product when submitting requests or claims.
Pegfilgrastim-class products are enumerated across the Preferred Oncology products tables.
Preferred products
Preferred when included on formulary for oncology use (no additional criteria provided in this section).
Clinical eligibility and coverage must still align with Diagnosis -Specific Criteria and NCCN recommendations.
Preferred products (informational)
Preferred when used for oncology indications as listed
Use the code-to-product mapping from the Preferred Oncology products tables when requesting coverage or billing.
Coverage tied to NCCN evidence categories and pediatric unconditional coverage
Covered when aligned with NCCN Categories 1 or 2A and benefit plan provisions; pediatric coverage is unconditional for chemotherapy agents:
Therapies listed in NCCN with Category 3 evidence are considered unproved and not medically necessary per policy.
Most pediatric treatments follow national pediatric protocols similar to NCCN guidelines.
This policy governs coverage of injectable oncology medications (including therapeutic radiopharmaceuticals) under the medical benefit using the National Comprehensive Cancer Network (NCCN) Drugs and Biologics Compendia® as the evidence source. It does not provide coverage criteria for Chimeric Antigen Receptor (CAR) T‑cell products or tumor‑infiltrating lymphocyte (TIL) cell products; separate guidelines address colony stimulating factors, erythropoiesis stimulating agents, bone‑modifying agents, and antiemetics. Coverage decisions depend on member benefits and alignment with NCCN compendium recommendations and evidence categories.
The provided excerpt does not list any explicit exclusions beyond the CAR T‑cell and TIL product exclusions noted elsewhere. Most chunks present a formulary‑style preferred product list; individual entries do not state additional product exclusions in the visible text.
No explicit exclusions are recorded in these chunks. The content is a preferred product listing mapping drug names to HCPCS/J and Q‑codes rather than a set of excluded therapies.
No explicit exclusions are listed in this section of the excerpt. Entries repeatedly denote products as preferred for oncology indications; exclusion language is absent.
These portions of the document present preferred product entries (many annotated “All oncology indications”) and do not state explicit exclusions for listed agents.
No exclusions are specified in these chunks. The text functions as a formulary/preferred products roster pairing agents with HCPCS/J/Q codes rather than an exclusions list.
No explicit exclusions are stated in these excerpts; the material reiterates preferred product designations (including multiple pegfilgrastim biosimilars and cytotoxic agents) without exclusionary statements for those listed.
These chunks continue the preferred products listing (pegfilgrastim group, melphalan, methotrexate, pemetrexed and others) and do not include explicit exclusions in the visible text.
Within the policy framework, therapies in the NCCN Drugs and Biologics Compendium with Category 3 evidence are considered unproved and not medically necessary for AlohaCare coverage determinations (subject to Benefits Considerations). Additionally, the J1442 listing for filgrastim is annotated as "excluded biosimilars", indicating certain biosimilars are excluded from that specific J‑code entry.
No additional explicit exclusions are stated in the provided portion of the document; the text primarily lists preferred products and applicable HCPCS/J/Q codes. Where exclusionary language appears, it is limited to the Category 3 compendia classification and the J1442 annotation noted above.
The excerpt does not enumerate further explicit exclusions. Instead, it clarifies that coverage decisions rely on NCCN evidence categories (Categories 1/2A considered proven; Category 3 considered unproved and not medically necessary) and member benefits, and that pediatric chemotherapy agents (age <19 years) are covered.
No explicit exclusions are stated in these chunks; the content is an informational preferred‑product list showing product names paired with preferred HCPCS/J‑ and Q‑codes for oncology indications.
The policy explicitly states that therapies listed in the NCCN Drugs and Biologics Compendium with Category 3 evidence are considered unproved and not medically necessary for AlohaCare coverage determinations (see Benefits Considerations). This is the principal not‑medically‑necessary rule present in the excerpt.
The J1442 line for filgrastim in the applicable codes list is annotated as "excluded biosimilars", which indicates that certain biosimilars are excluded from that specific J‑code listing. The document otherwise lists multiple biosimilar Q‑codes separately (e.g., Q5101, Q5110, etc.).
These chunks do not contain explicit "not medically necessary" statements beyond the general Category 3 rule; the document is primarily a preferred products listing and coding reference in the visible text.
No statements labeled "not medically necessary" are present in these chunks. The content repeats preferred product entries and associated codes without NMN declarations here.
No explicit "not medically necessary" conditions are listed in these sections. The preferred products lists predominate and NMN determinations are conveyed elsewhere (e.g., NCCN Category 3 language).
Not specified in these excerpts — the text lists preferred agents and codes; it does not provide additional NMN conditions beyond the Category 3 rule elsewhere in the document.
No explicit "not medically necessary" statements appear in these chunks; the policy primarily enumerates preferred products and code mappings.
These excerpts do not contain separate NMN statements; they reiterate preferred product listings and reference NCCN evidence categories which drive NMN determinations (Category 3 = not medically necessary).
No additional "not medically necessary" claims are presented in the visible text beyond the NCCN Category 3 classification noted above, which the policy uses to identify unproved therapies for coverage decisions.
Not specified in these chunks — the document section provides HCPCS/J/Q code descriptions and preferred product mappings; NMN conditions are not enumerated here other than the Category 3 rule referenced elsewhere.
The excerpt does not provide other NMN conditions. The principal NMN guidance in this section is: therapies with NCCN Category 3 evidence are considered unproved and not medically necessary for AlohaCare coverage determinations.
No new "not medically necessary" conditions are defined in these chunks. The policy relies on NCCN evidence categories to identify unproved therapies (Category 3) and otherwise lists preferred products and applicable codes.
The policy classifies agents cited in the NCCN Drugs and Biologics Compendium with Category 3 evidence as unproved and not medically necessary for AlohaCare coverage decisions; this classification is the key NMN rule present in the provided excerpts.
Applicable HCPCS / J / Q Codes and Mappings
| Q5110 | Nivestym (Filgrastim - aafi ) |
| Q5101 | Zarxio (Filgrastim - sndz) |
| J1442 | Neupogen (Filgrastim) |
| Q5148 | Nypozi (Filgrastim - txid) |
| Q5125 | Releuko (Filgrastim - ayow) |
| J1447 | Granix (TBO-filgrastim) |
| J9395 | Faslodex (Fulvestrant) |
| J9394 | Fulvestrant (Fresenius kabi) |
| J9393 | Fulvestrant (Teva) |
| J2353 | Sandostatin LAR (Octreotide Depot) |
| J0641 | Levoleucovorin |
| J0642 | Levoleucovorin |
| J0881 | Aranesp (Darbepoetin) |
| J0885 | Epogen/Procrit (Epoetin alfa) |
| Q5106 | Retacrit (Epoetin alfa - epbx) |
| Q5110 | Nivestym (Filgrastim - aafi) |
| Q5101 | Zarxio (Filgrastim - sndz) |
| J1442 | Neupogen (Filgrastim) |
| Q5148 | Nypozi (Filgrastim - txid) |
| Q5125 | Releuko (Filgrastim - ayow) |
| J9395 | Fulvestrant (Faslodex) |
| J9394 | Fulvestrant (Fresenius kabi) |
| J9393 | Fulvestrant (Teva) |
| J2353 | Sandostatin LAR (Octreotide Depot) |
| J1930 | Somatuline (Lanreotide) |
| J0640 | Leucovorin |
| J0641 | Levoleucovorin |
| J0642 | Levoleucovorin |
| J9217 | Eligard/Lupron Depot (Leuprolide) |
| J3315 | Trelstar (Triptorelin) |
| J1954 | Leuprolide (listed multiple brands) |
| J9202 | Goserelin (Zoladex) - oncology indications |
| J9245 | Melphalan |
| J9246 | Evomela (Melphalan) |
| J9249 | Ivra (Melphalan - apotex) |
| J9393 | Fulvestrant (Teva) |
| J9394 | Fulvestrant (Fresenius kabi) |
| J1930 | Somatuline (Lanreotide) |
| J0641 | Levoleucovorin |
| J0642 | Levoleucovorin (other) |
| Q5108 | Fulphila (Pegfilgrastim - jmdb) |
| Q5130 | Fylnetra (Pegfilgrastim - pbbk) |
| J2506 | Neulasta (Pegfilgrastim) |
| Q5111 | Udenyca (Pegfilgrastim - cbqv) |
| Q5122 | Nyvepria (Pegfilgrastim - apgf) |
| J1449 | Rolvedon (Eflapegrastim - xnst) |
| J9361 | Ryzneuta (Efbemalenograstim alfa - vuxw) |
| J9246 | Evomela (Melphalan) |
| J9249 | Ivra (Melphalan - apotex) |
| J9245 | Melphalan |
| J1952 | Camcevi / Lupron Depot (Leuprolide) |
| J1950 | Lupron Depot (Leuprolide) |
| J1954 | Lutrate / Vabrinty (Leuprolide) |
| J9202 | Zoladex (Goserelin) |
| J9246 | Evomela (Melphalan) |
| J9249 | Ivra (Melphalan - apotex) |
| J9255 | Methotrexate- accord |
| Q5111 | Udenyca (Pegfilgrastim - cbqv) |
| Q5108 | Fulphila (Pegfilgrastim - jmdb) |
| Q5130 | Fylnetra (Pegfilgrastim - pbbk) |
| J2506 | Neulasta (Pegfilgrastim) |
| Q5111 | Udenyca (Pegfilgrastim - cbqv) |
| Q5108 | Fulphila (Pegfilgrastim - jmdb) |
| Q5130 | Fylnetra (Pegfilgrastim - pbbk) |
| Q5122 | Nyvepria (Pegfilgrastim - apgf) |
| J1449 | Rolvedon (Eflapegrastim - xnst) |
| J9361 | Ryzneuta (Efbemalenograstim alfa - vuxw) |
| Q5127 | Stimufend (Pegfilgrastim - fpgk) |
| Q5120 | Ziextenzo (Pegfilgrastim - bmez) |
| J3315 | Trelstar (Triptorelin) |
| Q5122 | Nyvepria (Pegfilgrastim - apgf) |
| J1449 | Rolvedon (Eflapegrastim - xnst) |
| J9361 | Ryzneuta (Efbemalenograstim alfa - vuxw) |
| Q5127 | Stimufend (Pegfilgrastim - fpgk) |
| J1954 | Lutrate (Leuprolide) |
| J9202 | Zoladex (Goserelin) |
| J9245 | Melphalan |
| J9246 | Evomela (Melphalan) |
| J9249 | Ivra (Melphalan - apotex) |
| J9260 | Methotrexate |
| Q5127 | Ziextenzo (Pegfilgrastim - bmez) |
| Q5120 | Ziextenzo (Pegfilgrastim - bmez) repeated |
| J9202 | Zoladex (Goserelin) |
| J9245 | Evomela (Melphalan) |
| J9246 | Ivra (Melphalan - apotex) |
| J9249 | Melphalan (unspecified) |
| J9260 | Methotrexate |
| J9255 | Methotrexate - accord |
| J2506 | Neulasta (Pegfilgrastim) |
| Q5111 | Udenyca (Pegfilgrastim - cbqv) |
| J2506 | Neulasta (Pegfilgrastim) |
| Q5111 | Udenyca (Pegfilgrastim - cbqv) |
| Q5108 | Fulphila (Pegfilgrastim - jmdb) |
| Q5130 | Fylnetra (Pegfilgrastim - pbbk) |
| Q5122 | Nyvepria (Pegfilgrastim - apgf) |
| Q5127 | Stimufend (Pegfilgrastim - fpgk) |
| Q5120 | Ziextenzo (Pegfilgrastim - bmez) |
| J1449 | Rolvedon (Eflapegrastim - xnst) |
| J9361 | Ryzneuta (Efbemalenograstim alfa - vuxw) |
| J1449 | Ryzneuta (Efbemalenograstim alfa - vuxw) |
| J9361 | Stimufend (Pegfilgrastim - fpgk) |
| Q5127 | Ziextenzo (Pegfilgrastim - bmez) |
| Q5120 | Ziextenzo (Pegfilgrastim - bmez) |
| J9245 | Evomela (Melphalan) |
| J9246 | Ivra (Melphalan - apotex) |
| J9249 | Methotrexate |
| J9260 | Methotrexate- accord |
| J9255 | Neulasta (Pegfilgrastim) |
| J2506 | Udenyca (Pegfilgrastim - cbqv) |
| A9513 | Lutetium lu 177, dotatate, therapeutic, 1 millicurie |
| A9590 | Iodine i-131, iobenguane, 1 millicurie |
| A9606 | Radium Ra-223 dichloride, therapeutic, per microcurie |
| A9607 | Lutetium Lu 177 vipivotide tetraxetan, therapeutic, 1 millicurie |
| A9699 | Radiopharmaceutical, therapeutic, not otherwise classified |
| J0185 | Injection, aprepitant, 1 mg |
| J0640 | Injection, leucovorin calcium, 50 mg |
| J0641 | Injection, levoleucovorin, not otherwise specified, 0.5 mg |
| J0642 | Injection, levoleucovorin (khapzory), 0.5 mg |
| J0881 | Injection, darbepoetin alfa, 1 mcg (non - ESRD) |
| A9513 | Lutetium lu 177, dotatate, therapeutic, 1 millicurie |
| A9590 | Iodine i - 131, iobenguane, 1 millicurie |
| A9606 | Radium Ra-223 dichloride, therapeutic, per microcurie |
| A9607 | Lutetium Lu 177 vipivotide tetraxetan, therapeutic, 1 millicurie |
| A9699 | Radiopharmaceutical, therapeutic, not otherwise classified |
| J0185 | Injection, aprepitant, 1 mg |
| J0640 | Injection, leucovorin calcium, 50 mg |
| J0641 | Injection, levoleucovorin, not otherwise specified, 0.5 mg |
| J0642 | Injection, levoleucovorin (khapzory), 0.5 mg |
| J0881 | Injection, darbepoetin alfa, 1 mcg (non - esrd) |
| J0885 | Injection, epoetin alfa, 1000 units (non - esrd) |
| J0897 | Injection, denosumab, 1 mg |
| J1434 | Injection, fosaprepitant (focinvez), 1 mg |
| J1442 | Injection, filgrastim (g - csf), excluded biosimilars, 1 mcg |
| J1447 | Injection, tbo -filgrastim, 1 mcg |
| J1449 | Injection, eflapegrastim - xnst, 0.1 mg |
| J1453 | Injection, fosaprepitant, 1 mg |
| J1626 | Injection, granisetron hydrochloride, 100 mcg |
| J1930 | Injection, lanreotide, 1 mg |
| J1950 | Injection, leuprolide acetate (for depot suspension), 3.75 mg |
| J2353 | Injection, octreotide, depot form for intramuscular injection, 1 mg |
| J3262 | Injection, tocilizumab, 1 mg |
| J2405 | Injection, ondansetron hydrochloride, per 1 mg |
| J2506 | Injection, pegfilgrastim, excludes biosimilar, 0.5 mg |
| J2562 | Injection, plerixafor, 1 mg |
| J3315 | Injection, triptorelin pamoate, 3.75 mg |
| J9033 | Injection, bendamustine hydrochloride, 1 mg |
| J9035 | Injection, bevacizumab, 10 mg |
| J9041 | Injection, bortezomib, 0.1mg |
| J9054 | Injection, bortezomib (Boruzu), 0.1 mg |
| J9171 | Injection, docetaxel, 1 mg |
| J9245 | Injection, melphalan hydrochloride, not otherwise specified, 50 mg |
| J9260 | Injection, methotrexate sodium, 50 mg |
| J9292 | Injection, pemetrexed dipotassium, 10 mg |
| J9311 | Injection, rituximab 10 mg and hyaluronidase |
| J9355 | Injection, trastuzumab, 10 mg |
| Q0166 | Granisetron hydrochloride, 1 mg, oral, FDA approved prescription anti-emetic |
| Q5101 | Injection, filgrastim-sndz, biosimilar, (zarxio), 1 microgram |
| Q5106 | Injection, epoetin alfa-epbx, biosimilar, (retacrit) (for non-ESRD use), 1000 units |
| Q5112 | Injection, trastuzumab-dttb, biosimilar, (ontruzant), 10 mg |
| Q5115 | Injection, rituximab-abbs, biosimilar, (truxima) 10 mg |
| Q5120 | Injection, pegfilgrastim-bmez (ziextenzo), biosimilar, 0.5 mg |
| Q5123 | Injection, rituximab-arrx, biosimilar, (Riabni), 10 mg |
| Q5146 | Injection, trastuzumab-strf (Hercessi), biosimilar, 10 mg |
Provider Actions, Billing and Prior Authorization Guidance
Prior authorization required for non-preferred oncology products
Treatment with a non-preferred oncology product is medically necessary only when BOTH: (1) the member has a history of intolerance or contraindication to two AlohaCare preferred products (unless there is only one preferred product available) AND (2) the physician attests that the same intolerance, contraindication, or adverse event would not be expected to occur with the requested non-preferred product.
- Document history of intolerance/contraindication to two preferred AlohaCare products (unless only one preferred product exists).
- Obtain physician attestation that the adverse event/intolerance is not expected with the non-preferred agent.
Use listed preferred product codes for PA and billing
When requesting coverage or submitting claims, use the HCPCS/J- or Q-code that corresponds to the AlohaCare-listed preferred product (preferred product codes are enumerated in the preferred products tables).
- Select the listed preferred product code on prior authorization requests and claims to reflect the payer-preferred agent.
Preferred product — HCPCS/J-/Q-code mappings listed
Preferred products are paired with specific HCPCS/J- and Q-codes in the policy tables (examples include J1442, J1447, J2506, Q5108, Q5111, J9245, J9260 among many others); these code-to-product mappings identify the payer-preferred agents for oncology indications.
- Refer to the policy's preferred products tables for the full list of HCPCS/J/Q codes associated with preferred agents.
Preferred product codes enumerated (informational)
The document lists numerous HCPCS/J/Q codes as preferred oncology products (for example J9395, J9246, J0640, Q5148, Q5125); the policy text does not add separate prior-authorization mechanics within these listing chunks.
- Codes in the preferred list are informational but are used to identify payer-preferred agents.
Preferred products and associated HCPCS/J-codes (annotated)
The preferred-products tables enumerate agents and associated HCPCS/J-codes and frequently annotate entries as 'All oncology indications' for many products; these listings identify the preferred agents for oncology use though specific PA conditions are described elsewhere.
- Many entries are annotated 'All oncology indications' — use those code mappings when billing for oncology indications.
Preferred oncology product code listings (use for identification)
The policy provides a preferred product roster paired with HCPCS/J- and Q-codes (e.g., multiple pegfilgrastim biosimilars and melphalan/methotrexate codes); these codes function as the payer’s preferred-product identifiers for oncology indications.
- Use the exact HCPCS/J/Q code from the preferred-products table when documenting or billing the preferred agent.
Use listed HCPCS/J-/Q-codes when submitting PA requests and claims
Submit prior authorization requests and claims using the HCPCS/J- or Q-code listed beside the preferred product in the tables (selected examples include J1952, J2506, Q5111, Q5122, J9246).
- Ensure PA forms and claims reference the code that matches the preferred product name in the policy table.
Preferred product code list (informational)
The document’s preferred-product sections are primarily informational code–to–product lists; the policy does not define PA criteria within each listing chunk but these codes may be implicated in utilization management.
- Treat the code lists as the authoritative mapping of AlohaCare preferred products; check other policy sections for PA requirements.
Preferred products — code list (reference)
A long enumerated list pairs preferred oncology products with HCPCS/J/Q codes (pegfilgrastim biosimilars, melphalan, pemetrexed, leuprolide/goserelin entries); the chunks document the preferred codes but do not add separate PA conditions in these excerpts.
- Reference these code listings for billing and product selection; PA conditions are covered in other policy text.
Preferred product codes (informational — oncology)
The policy lists preferred oncology HCPCS/J/Q codes (including multiple pegfilgrastim biosimilars, eflapegrastim, and others); these codes are identified as preferred for oncology indications though the excerpt does not impose additional PA rules here.
- When selecting an agent for oncology use, ensure the administered product and billing code match a listed preferred entry.
Preferred oncology product codes — use for PA and claims
The preferred-products table identifies HCPCS/J/Q codes that AlohaCare treats as the payer-preferred identifiers for listed oncology agents; providers should reference these codes on claims and PA requests for the listed products.
- Listing of a code does not guarantee coverage; verify coverage against Diagnosis‑Specific Criteria and benefit terms.
Formulary / Covered Regimens and Product Lists
not_specified
Further sections of the full policy may define line-of-therapy requirements.
| Regimen / Listing | Coverage |
|---|---|
| Not applicable — listing of individual preferred products (supportive care and oncology supportive agents: growth factors, epoetins, bone-modifying agents, hormonal depot agents). | |
| This section enumerates individual preferred products rather than protocolized multi‑drug regimens; use of listed agents is governed by the preferred products guidance and applicable coverage criteria (see Diagnosis‑Specific Criteria). |
| Preferred Product(s) | Indication / Notes |
|---|---|
| Multiple pegfilgrastim products (Neulasta J2506; Fulphila Q5108; Fylnetra Q5130; Nyvepria Q5122; Udenyca Q5111; Stimufend Q5127; Ziextenzo Q5120) | |
| Listed as preferred for 'All oncology indications' where explicitly stated in the product list; providers should bill using the listed HCPCS/J/Q code for the preferred product. |
| Preferred Product(s) | Indication / Notes |
|---|---|
| Leuprolide / goserelin / triptorelin products (Camcevi J1952; Lupron J1950; Lutrate J1954; Eligard J9217; Trelstar J3315; Zoladex J9202) | |
| Alkylators and antimetabolites including melphalan (J9245/J9246/J9249), methotrexate (J9260/J9255), pemetrexed (J9305/J9304/J9294/J9324), and leucovorin (J0640/J0641/J0642) are listed as preferred for oncology uses. |
| Preferred Agent / Code | Coverage / Indication |
|---|---|
| Leuprolide products: Camcevi (J1952), Lupron Depot (J1950), Lutrate (J1954), Eligard (J9217); Goserelin: Zoladex (J9202) | |
| Melphalan formulations: Melphalan (J9245), Evomela (J9246), Ivra (J9249); Methotrexate: J9260, J9255; Pegfilgrastim originator and biosimilars (J2506, Q5111, Q5108, Q5130, Q5122, Q5127, Q5120); Eflapegrastim J1449 and other G‑CSF agents listed as preferred. |
| Preferred Injectable Product | Notes / Indication |
|---|---|
| Pegfilgrastim and pegfilgrastim biosimilars: Neulasta (J2506), Udenyca (Q5111), Fulphila (Q5108), Fylnetra (Q5130), Nyvepria (Q5122), Stimufend (Q5127), Ziextenzo (Q5120) | |
| Document lists these injectable agents as preferred for oncology uses; many entries are annotated 'All oncology indications' in the preferred products list. |
| Preferred Product(s) | Scope / Indication |
|---|---|
| Pegfilgrastim products (J2506 and multiple Q‑codes), melphalan (J9245/J9246/J9249), methotrexate (J9260/J9255), pemetrexed (J9305/J9304/J9294/J9324), leuprolide/goserelin therapies (J1950/J1952/J1954/J9217/J9202) | |
| Listed as preferred for oncology use; many entries specify 'All oncology indications' in the document excerpts. |
| Preferred Agent(s) | Coverage / Indication |
|---|---|
| Multiple agents including pegfilgrastim biosimilars (Q5108/Q5130/Q5122/Q5111/Q5127/Q5120), melphalan formulations (J9245/J9246/J9249), methotrexate (J9260/J9255), pemetrexed (J9305/J9304), and leuprolide/goserelin products (J1950/J1952/J1954/J9217/J9202) | |
| Preferred for oncology indications as listed; the product list is formulary‑style rather than a protocolized regimen. |
| Formulary Product | Remarks |
|---|---|
| Preferred oncology products (formulary listing) including multiple pegfilgrastim biosimilars, melphalan, methotrexate, pemetrexed, and hormonal depot agents. | |
| This is a preferred‑product formulary list and not a protocolized multi‑drug regimen; some entries are annotated 'All oncology indications'. |
| Preferred Product(s) | Coverage / Indication |
|---|---|
| Pegfilgrastim products and biosimilars (J2506, Q5111, Q5108, Q5130, Q5122, Q5127, Q5120); Melphalan (J9245/J9246/J9249); Methotrexate (J9260/J9255); Pemetrexed (J9305/J9304/J9294/J9324) | |
| Preferred formulary listing of oncology drugs; indication details are not expanded in the excerpt beyond frequent 'All oncology indications' annotations. |
| Product / HCPCS-J/Q Code | Preferred Status |
|---|---|
| Neulasta (J2506); Fulphila (Q5108); Udenyca (Q5111); Fylnetra (Q5130); Nyvepria (Q5122); Stimufend (Q5127); Ziextenzo (Q5120); Rolvedon (J1449); Ryzneuta (J9361) | |
| Pemetrexed products: Alimta (J9305), Pemfexy (J9304), Pemetrexed alternate (J9294), Pemrydi RTU (J9324); Melphalan J9245/J9246/J9249; Methotrexate J9260/J9255 — all listed among preferred products. |
| Antiemetic Product (HCPCS) | Preferred / Notes |
|---|---|
| Aloxi (Palonosetron) IV J2469; Emend (Fosaprepitant) IV J1453; Emend (Aprepitant) PO J8501; Akynzeo IV J1454 / PO J8655; Kytril IV J1626 / PO Q0166; Zofran IV J2405 / PO Q0162 | |
| Additional antiemetics listed: Cinvanti (Aprepitant) J0185; Focinvez (Fosaprepitant) J1434; Posfrea (Palonosetron) J2468; Sustol (Granisetron ER) J1627 — preferred antiemetic products enumerated in the document. |
Definitions and Reference Concepts
Background and Scope
This guideline governs coverage of injectable oncology medications and therapeutic radiopharmaceuticals under the medical benefit using the NCCN Drugs and Biologics Compendia to establish evidence‑based indication support. Coverage for preferred products is contingent on meeting applicable coverage criteria and benefit provisions; non‑preferred products are medically necessary only when the member has documented intolerance or contraindication to two AlohaCare preferred products (unless only one preferred product exists) and the treating physician attests the same adverse event would not be expected with the requested non‑preferred agent. Pediatric chemotherapy agents (age <19 years) are covered per policy. Refer to the applicable codes table for HCPCS/J/Q mappings and note that some entries (e.g., J1442) annotate excluded biosimilars.
Policy Revision History
Policy adopted.
Document updated (unspecified content changes).
Document updated / last revised (reflects current preferred products guidance).
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