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    v1.0.30
    OpenPayerBilling CodesChemotherapy DrugsHCPCS hcpcs-j9041-bortezomib-injection-0-1-mg
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    HCPCS Level II J9041: Injection, bortezomib, 0.1 mg

    HCPCS Level II code J9041 describes billing for an injection of bortezomib, 0.1 mg, used as an antineoplastic agent administered for chemotherapy; the service is an injectable chemotherapy drug administration typically provided in outpatient oncology clinics or infusion centers and documented for drug dosing and dispensing on the medical claim.

    For related coverage guidance, see recent payer policy updates: T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and Romidepsin, Tumor Treatment Fields - Medical Policy, Extracorporeal Photopheresis.

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old patient with relapsed multiple myeloma presents to the outpatient oncology infusion center for administration of chemotherapy. The regimen includes bortezomib given by subcutaneous or intravenous injection using HCPCS Level II code J9041 billed per 0.1 mg unit. The clinical workflow begins with verification of diagnosis and treatment plan by the oncologist, review of prior therapy and laboratory results (including complete blood count and hepatic function), informed consent, and site-of-care assessment. Nursing performs medication preparation per pharmacy protocol, verifies dose calculation (mg and total mg based on body surface area or flat dosing per regimen), confirms route (subcutaneous preferred for reduced neuropathy risk) and administers the injection. Vital signs and toxicity monitoring occur during and after administration; documentation includes exact dose, lot numbers, route, site, time, and any immediate reaction. Pharmacy and billing convert administered milligrams to units of J9041 (0.1 mg per unit) for accurate HCPCS billing and attach applicable modifier codes to reflect circumstances such as professional services, drug wastage, or patient status changes.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96413Chemotherapy administration, infusion technique; intravenous infusion, each additional hour (List separately in addition to primary)Used when continuous infusion chemotherapy is provided in conjunction with injectable agents; not typical for single bortezomib bolus but may apply if combined regimens include infusional agents
    96417Chemotherapy administration, intravenous push, single or initial substance/drugUse when bortezomib is given as an IV push (initial or single drug administration)
    96415Chemotherapy administration, intravenous; each additional sequential infusion (the code set includes variations)Applies if multiple sequential IV infusions are administered during the same encounter alongside bortezomib
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularCommonly used for billing the administration service when bortezomib is given subcutaneously if payer requires separate administration code
    96401Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anticancer drug, single or initial substance/drugUsed to report subcutaneous administration of an anticancer agent such as bortezomib when payer accepts chemotherapy administration codes

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    363LF0000X
    251B00000X
    3336C0003X
    207RP1001X
    333600000X
    332BD1200X
    2083S0010X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    C76.0Malignant neoplasm of head, face and neck
    C77.0Secondary and unspecified malignant neoplasm of lymph nodes of head, face and neck
    C81.90Hodgkin lymphoma, unspecified, unspecified site
    C81.99Hodgkin lymphoma, unspecified, extranodal and solid organ sites
    C83.30Diffuse large B-cell lymphoma, unspecified site
    C83.31Diffuse large B-cell lymphoma, lymph nodes of head, face, and neck
    C85.80Other specified types of non-Hodgkin lymphoma, unspecified site
    C85.89Other specified types of non-Hodgkin lymphoma, extranodal and solid organ sites
    C90.00Multiple myeloma not having achieved remission
    C90.01Multiple myeloma in remission

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and RomidepsinMass General Brigham Health Plan2027-01-04
    Tumor Treatment Fields - Medical PolicyHealth-New-England2026-12-01
    Extracorporeal PhotopheresisCigna2026-11-15
    Electric Tumor Treatment Field Therapy (for Tennessee Only)Colorado Rocky Mountain Health Plans2026-11-01
    Tumor Treating Fields Therapypremerabluecrossofwashington2026-11-01
    Tumor Treating Fields Therapypremerabluecrossofwashington2026-11-01
    OmisirgeCigna2026-11-01
    Hematology - AdzynmaCigna2026-10-15
    Transcatheter Arterial Chemoembolization for Liver Tumorspremerabluecrossofwashington2026-10-01
    Cryoablation of Tumors Located in the Kidney, Lung, Breast, Pancreas, or Bonepremerabluecrossofwashington2026-10-01

    Related Codes

    HCPCS-J9000-DOXORUBICIN-10MG-INJECTION

    HCPCS J9000: Doxorubicin Hydrochloride Injection, 10 mg

    HCPCS-J9003-LEUPROLIDE-INJECTABLE-CAMCEVI-1MG

    HCPCS Level II J9003: Leuprolide injectable (camcevi etm), 1 mg

    HCPCS-J9010-ALEMTUZUMAB-INJECTION-10MG

    HCPCS Level II J9010: Injection, alemtuzumab, 10 mg

    HCPCS-J9011-DATOPOTAMAB-DERUXTECAN-INJECTION-1MG

    HCPCS J9011: Datopotamab Deruxtecan Injection, 1 mg

    HCPCS-J9015-ALDESLEUKIN-INJECTION-SINGLE-USE-VIAL

    HCPCS Level II J9015: Aldesleukin Injection, Single-Use Vial

    HCPCS-J9017-ARSENIC-TRIOXIDE-INJECTION-1MG

    HCPCS J9017: Arsenic Trioxide Injection, 1 mg

    HCPCS-J9019-ASPARAGINASE-ERWINAZE-INJECTION-1000-IU

    HCPCS Level II J9019: Asparaginase (Erwinaze) Injection, 1,000 IU

    HCPCS-J9020-ASPARAGINASE-INJECTION-10000-UNITS

    HCPCS J9020: Asparaginase Injection, 10,000 Units

    HCPCS-J9021-ASPARAGINASE-RYLAZE-INJECTION-0-1-MG

    HCPCS Level II J9021: Injection, asparaginase (Rylaze), 0.1 mg

    HCPCS-J9022-ATEZOLIZUMAB-INJECTION-10MG

    HCPCS J9022: Injection, atezolizumab 10 mg

    Showing 1–10 of 227

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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