HCPCS Level II code J9255 describes a 50 mg injection of methotrexate (brand listed as Accord) identified as not therapeutically equivalent to J9260; this code represents medication administration for systemic methotrexate therapy, typically billed when the single‑dose injectable drug product is provided for infusion or injection in outpatient infusion centers, physician offices, or hospital outpatient departments and is associated with parenteral chemotherapy or disease‑modifying treatment.

For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chimeric Antigen Receptor (CAR) T-Cell Therapy, Antibody-Drug Conjugates.