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    v1.0.28
    OpenPayerBilling CodesPersons with potential health hazards related to family and personal history and certain conditions influencing health statusICD-10-CM z88-allergy-status-to-drugs-medicaments
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    ICD-10-CM Code For Allergy Status To Drugs Medicaments And Biological Substances: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group Z88 includes diagnoses indicating a patient's documented allergy or adverse reaction status to drugs, medicaments, and biological substances, such as penicillin allergy or sensitivity to vaccines. These ICD-10-CM diagnosis codes are used to document clinical scenarios where a known drug allergy or reaction influences treatment decisions, medication selection, or procedural planning. Accurate coding within the ICD-10-CM Z88 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM Z88: Allergy Status To Drugs, Medicaments And Biological Substances Overview

    This diagnosis group documents a patients known allergy or adverse reaction history to drugs, medicaments, and biological substances, and flags potential hazards for future care. It targets medication-related hypersensitivity information rather than active disease of a specific organ system. Accurate coding ensures the allergy history is visible in claims and clinical records, which supports safe care and appropriate reimbursement.

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    When to Use

    Use a code from this group when a patient has a documented allergy or adverse reaction to a medication or biological substance that is relevant to current or future care. These codes are applied when the allergy status affects treatment choices, precludes certain therapies, or must be included in the medical record for safety and billing.

    ICD-10-CM Codes

    10 rows

    ICD-10-CM CodeDescription
    Z88.0Allergy status to penicillin
    Z88.1Allergy status to other antibiotic agents
    Z88.2Allergy status to sulfonamides
    Z88.3Allergy status to other anti-infective agents
    Z88.4Allergy status to anesthetic agent
    Z88.5Allergy status to narcotic agent
    Z88.6Allergy status to analgesic agent
    Z88.7Allergy status to serum and vaccine
    Z88.8Allergy status to other drugs, medicaments and biological substances
    Z88.9Allergy status to unspecified drugs, medicaments and biological substances

    DRG Codes

    1 rows

    DRG CodeDescription
    951Other Factors Influencing Health Status

    Related Codes

    Z77-OTHER-CONTACT-WITH-EXPOSURES

    ICD-10-CM Code For Other Contact With And Suspected Exposures Hazardous To Health: Group Overview

    Z78-OTHER-SPECIFIED-HEALTH-STATUS

    ICD-10-CM Code For Other Specified Health Status: Group Overview

    Z79-LONG-TERM-DRUG-THERAPY

    ICD-10-CM Code For Long Term Current Drug Therapy: Group Overview

    Z80-FAMILY-HISTORY-OF-CANCER

    ICD-10-CM Code For Family History Of Primary Malignant Neoplasm: Group Overview

    Z81-FAMILY-HISTORY-OF-MENTAL-DISORDERS

    ICD-10-CM Code For Family History Of Mental And Behavioral Disorders: Group Overview

    Z82-FAMILY-HISTORY-OF-DISABILITIES

    ICD-10-CM Code For Family History Of Certain Disabilities And Chronic Diseases: Group Overview

    Z83-FAMILY-HISTORY-OF-OTHER-SPECIFIC-DISORDERS

    ICD-10-CM Code For Family History Of Other Specific Disorders: Group Overview

    Z84-FAMILY-HISTORY-OTHER-CONDITIONS

    ICD-10-CM Code For Family History Of Other Conditions: Group Overview

    Z85-PERSONAL-HISTORY-OF-MALIGNANT-NEOPLASM

    ICD-10-CM Code For Personal History Of Malignant Neoplasm: Group Overview

    Z86-PERSONAL-HISTORY-OF-CERTAIN-DISEASES

    ICD-10-CM Code For Personal History Of Certain Other Diseases: Group Overview

    Showing 1–10 of 22

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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