ICD-10-PCS Code For Renal Sympathetic Nerve(s): Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group X051 includes procedures performed to destroy neural tissue in the renal sympathetic nerve(s) in the nervous system. These ICD-10-PCS codes are used for inpatient documentation when a clinician performs physical eradication of all or a portion of the renal sympathetic nerve(s) using energy, force, or a destructive agent. Accurate coding within the ICD-10-PCS X051 group is essential for proper inpatient reimbursement, as it captures the procedure performed and supports clinical documentation accuracy.

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Renal Sympathetic Nerve Destruction Procedure Overview

This procedure group includes destruction of the renal sympathetic nerves within the nervous system, typically performed to interrupt sympathetic signaling to the kidney. Procedures use direct energy, force, or a destructive agent applied to the renal sympathetic nerve(s). Accurate coding of these procedures in the inpatient setting ensures the procedure is captured correctly for clinical documentation and reimbursement.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
X	Section	New Technology
0	Body System	Nervous System
5	Operation	Destruction
1	Body Part	Renal Sympathetic Nerve(s)

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ICD-10-PCS Code For Renal Sympathetic Nerve(s): Procedure Code Group Overview

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Renal Sympathetic Nerve Destruction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
X	Section	New Technology
0	Body System	Nervous System
5	Operation	Destruction
1	Body Part	Renal Sympathetic Nerve(s)

When to Use

Use a code from this group when the operative intent and documentation indicate destruction of the renal sympathetic nerve(s) as the primary procedure. Do not use these codes for procedures that only expose, monitor, or manipulate the nerve without physically destroying nerve tissue.

ICD-10-PCS Codes

2 rows

ICD-10-PCS Code	Description
X051329	Destruction of Renal Sympathetic Nerve(s) using Ultrasound Ablation, Percutaneous Approach, New Technology Group 9
X05133A	Destruction of Renal Sympathetic Nerve(s) using Radiofrequency Ablation, Percutaneous Approach, New Technology Group 10

DRG Codes

4 rows

DRG Code	Description
040	Peripheral, Cranial Nerve and Other Nervous System Procedures with MCC
041	Peripheral, Cranial Nerve and Other Nervous System Procedures with CC or Peripheral Neurostimulator
042	Peripheral, Cranial Nerve and Other Nervous System Procedures without CC/MCC
264	Other Circulatory System O.R. Procedures

Typical Clinical Scenarios

A middle-aged patient with resistant hypertension despite maximally tolerated multi-drug therapy is admitted for planned inpatient evaluation and percutaneous renal sympathetic denervation to reduce sympathetic-driven blood pressure elevation; the procedure is performed percutaneously using radiofrequency energy to ablate renal sympathetic nerve fibers under image guidance. Typical codes: X05133A
An elderly patient with refractory heart failure and sympathetic overactivity is electively admitted for percutaneous renal nerve modulation as part of advanced heart failure management; the team performs percutaneous ultrasound-based ablation targeting the renal sympathetic nerves to reduce neurohormonal activation contributing to volume overload. Typical codes: X051329
A patient who previously underwent percutaneous renal sympathetic ablation returns with recurrent hypertension; after inpatient workup confirming recurrence of sympathetic-mediated blood pressure elevation, a repeat percutaneous radiofrequency ablation of the renal sympathetic nerves is performed to re-establish nerve disruption. Typical codes: X05133A

ICD-10-PCS Code For Thoracic Sympathetic Nerve, Cardiac Plexus: Procedure Code Group Overview

X053-BRAIN-DESTRUCTION

ICD-10-PCS Code For Brain: Procedure Code Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

2 rows

ICD-10-PCS Code	Description
X051329	Destruction of Renal Sympathetic Nerve(s) using Ultrasound Ablation, Percutaneous Approach, New Technology Group 9
X05133A	Destruction of Renal Sympathetic Nerve(s) using Radiofrequency Ablation, Percutaneous Approach, New Technology Group 10

DRG Codes

4 rows

DRG Code	Description
040	Peripheral, Cranial Nerve and Other Nervous System Procedures with MCC
041	Peripheral, Cranial Nerve and Other Nervous System Procedures with CC or Peripheral Neurostimulator
042	Peripheral, Cranial Nerve and Other Nervous System Procedures without CC/MCC
264	Other Circulatory System O.R. Procedures

Typical Clinical Scenarios

A middle-aged patient with resistant hypertension despite maximally tolerated multi-drug therapy is admitted for planned inpatient evaluation and percutaneous renal sympathetic denervation to reduce sympathetic-driven blood pressure elevation; the procedure is performed percutaneously using radiofrequency energy to ablate renal sympathetic nerve fibers under image guidance. Typical codes: X05133A
An elderly patient with refractory heart failure and sympathetic overactivity is electively admitted for percutaneous renal nerve modulation as part of advanced heart failure management; the team performs percutaneous ultrasound-based ablation targeting the renal sympathetic nerves to reduce neurohormonal activation contributing to volume overload. Typical codes: X051329
A patient who previously underwent percutaneous renal sympathetic ablation returns with recurrent hypertension; after inpatient workup confirming recurrence of sympathetic-mediated blood pressure elevation, a repeat percutaneous radiofrequency ablation of the renal sympathetic nerves is performed to re-establish nerve disruption. Typical codes: X05133A

ICD-10-PCS Code For Thoracic Sympathetic Nerve, Cardiac Plexus: Procedure Code Group Overview

X053-BRAIN-DESTRUCTION

ICD-10-PCS Code For Brain: Procedure Code Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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ICD-10-PCS Code For Renal Sympathetic Nerve(s): Procedure Code Group Overview

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Renal Sympathetic Nerve Destruction Procedure Overview

Code Attributes

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ICD-10-PCS Code For Renal Sympathetic Nerve(s): Procedure Code Group Overview

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Renal Sympathetic Nerve Destruction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Renal Sympathetic Nerve(s): Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Renal Sympathetic Nerve(s): Procedure Code Group Overview policy alerts

Renal Sympathetic Nerve Destruction Procedure Overview

Code Attributes

ICD-10-PCS Code For Renal Sympathetic Nerve(s): Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Renal Sympathetic Nerve(s): Procedure Code Group Overview policy alerts

Renal Sympathetic Nerve Destruction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS code group covers destruction of the renal sympathetic nerve(s)?

What are the specific codes listed in the X051 group and their approaches?

What is the defined operation and body system for codes in this group?

How does coding in the X051 group affect inpatient reimbursement?

Which DRGs are related to procedures in the X051 code group?

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS code group covers destruction of the renal sympathetic nerve(s)?

What are the specific codes listed in the X051 group and their approaches?

What is the defined operation and body system for codes in this group?

How does coding in the X051 group affect inpatient reimbursement?

Which DRGs are related to procedures in the X051 code group?

References