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    OpenPayerBilling CodesChromosomal abnormalities, not elsewhere classifiedICD-10-CM q98-other-sex-chromosome-abnormalities-male-phenotype
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    ICD-10-CM Code For Other Sex Chromosome Abnormalities Male Phenotype Not Elsewhere Classified: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group Q98 includes congenital sex chromosome abnormalities in individuals with a male phenotype that are not classified elsewhere, such as atypical sex chromosome complements leading to disorders of sexual development. These ICD-10-CM diagnosis codes are used to document clinical scenarios involving chromosomal anomalies affecting sexual differentiation, gonadal development, and associated genitourinary or endocrine manifestations. Accurate coding within the ICD-10-CM Q98 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM Q98: Other Sex Chromosome Abnormalities, Male Phenotype, Not Elsewhere Classified Overview

    This code group represents congenital chromosomal abnormalities involving sex chromosomes in individuals with a male phenotype that do not fit more specific categories. It targets genetic and developmental conditions affecting sexual differentiation and related systems. Accurate coding matters for clinical records and reimbursement because it clarifies the diagnosis for claim adjudication and ensures appropriate documentation of complexity.

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    When to Use

    Use a code from this group when a documented chromosomal abnormality affecting sex chromosomes is present in a patient with a male phenotype and no more specific International Classification of Diseases, Tenth Revision, Clinical Modification code applies. These codes apply when clinical documentation or genetic testing identifies an atypical sex chromosome finding linked to phenotypic male sexual development and there is no alternative categorized diagnosis.

    ICD-10-CM Codes

    9 rows

    ICD-10-CM CodeDescription
    Q98.0Klinefelter syndrome karyotype 47, XXY
    Q98.1Klinefelter syndrome, male with more than two X chromosomes
    Q98.3Other male with 46, XX karyotype
    Q98.4Klinefelter syndrome, unspecified
    Q98.5Karyotype 47, XYY
    Q98.6Male with structurally abnormal sex chromosome
    Q98.7Male with sex chromosome mosaicism
    Q98.8Other specified sex chromosome abnormalities, male phenotype
    Q98.9Sex chromosome abnormality, male phenotype, unspecified

    DRG Codes

    6 rows

    DRG CodeDescription
    729Other Male Reproductive System Diagnoses with CC/MCC
    730Other Male Reproductive System Diagnoses without CC/MCC
    742Uterine and Adnexa Procedures for Non-Malignancy with CC/MCC
    743Uterine and Adnexa Procedures for Non-Malignancy without CC/MCC
    760Menstrual and Other Female Reproductive System Disorders with CC/MCC
    761Menstrual and Other Female Reproductive System Disorders without CC/MCC

    Typical Clinical Scenarios

    • A newborn male infant is noted at birth to have micropenis, cryptorchidism, and dysmorphic facial features during the initial neonatal exam and endocrinology consult; karyotype reveals 47,XYY or other supernumerary Y mosaicism consistent with an extra Y chromosome variant, so a chromosomal abnormality in a phenotypic male is coded to document the congenital finding and guide follow-up. Typical codes: Q98.8, Q98.9.
    • An adolescent male presents for evaluation of delayed puberty, tall stature, and learning difficulties; chromosomal analysis demonstrates 47,XXY mosaicism or other sex chromosome anomaly in a predominantly male phenotype, prompting a diagnosis from this group to explain the endocrine and developmental features and coordinate endocrine and psychosocial care. Typical codes: Q98.4, Q98.1.
    • An adult male with infertility undergoes reproductive evaluation after years of unsuccessful conception; semen analysis shows azoospermia and subsequent genetic testing identifies a sex chromosome abnormality (such as structural Y-chromosome abnormality) as the underlying cause, so a code from this group is assigned as the comorbid chromosomal etiology affecting fertility management. Typical codes: Q98.6, Q98.3.

    Related Codes

    Q90-DOWN-SYNDROME

    ICD-10-CM Code For Down Syndrome: Group Overview

    Q91-TRISOMY-18-AND-TRISOMY-13

    ICD-10-CM Code For Trisomy 18 And Trisomy 13: Group Overview

    Q92-OTHER-TRISOMIES-AND-PARTIAL-TRISOMIES

    ICD-10-CM Code For Other Trisomies And Partial Trisomies Of The Autosomes Not Elsewhere Classified: Group Overview

    Q93-MONOSOMIES-AND-DELETIONS

    ICD-10-CM Code For Monosomies And Deletions From The Autosomes Not Elsewhere Classified: Group Overview

    Q95-BALANCED-REARRANGEMENTS-AND-STRUCTURAL-MARKERS

    ICD-10-CM Code For Balanced Rearrangements And Structural Markers Not Elsewhere Classified: Group Overview

    Q96-TURNERS-SYNDROME

    ICD-10-CM Code For Turner's Syndrome: Group Overview

    Q97-OTHER-SEX-CHROMOSOME-ABNORMALITIES-FEMALE-PHENOTYPE

    ICD-10-CM Code For Other Sex Chromosome Abnormalities Female Phenotype Not Elsewhere Classified: Group Overview

    Q99-OTHER-CHROMOSOME-ABNORMALITIES-NOT-ELSEWHERE-CLASSIFIED

    ICD-10-CM Code For Other Chromosome Abnormalities, Not Elsewhere Classified: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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