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    v1.0.28
    OpenPayerBilling CodesChromosomal abnormalities, not elsewhere classifiedICD-10-CM q91-trisomy-18-and-trisomy-13
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    ICD-10-CM Code For Trisomy 18 And Trisomy 13: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group Q91 includes diagnoses for trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome), congenital chromosomal disorders characterized by multiple structural and developmental anomalies. These ICD-10-CM diagnosis codes are used to document the presence and specific form of autosomal trisomies in newborns and patients with congenital anomalies, capturing disease severity, organ involvement, and clinical complexity relevant to this group. Accurate coding within the ICD-10-CM Q91 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM Q91: Trisomy 18 And Trisomy 13 Overview

    The ICD-10-CM Q91 group represents trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome), which are chromosomal abnormalities affecting multiple organ systems with marked developmental and structural anomalies. These conditions target congenital multisystem and neurodevelopmental impairments and often involve cardiac, craniofacial, and central nervous system malformations. Accurate coding matters for appropriate clinical documentation and can affect reimbursement and resource allocation for complex congenital care.

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    When to Use

    Use a code from this group when a patient is diagnosed with trisomy 18 or trisomy 13 based on chromosomal testing or clinical diagnosis documented by a clinician. Apply the specific code that reflects the confirmed trisomy and any associated congenital anomalies or complications documented in the medical record.

    ICD-10-CM Codes

    8 rows

    ICD-10-CM CodeDescription
    Q91.0Trisomy 18, nonmosaicism (meiotic nondisjunction)
    Q91.1Trisomy 18, mosaicism (mitotic nondisjunction)
    Q91.2Trisomy 18, translocation
    Q91.3Trisomy 18, unspecified
    Q91.4Trisomy 13, nonmosaicism (meiotic nondisjunction)
    Q91.5Trisomy 13, mosaicism (mitotic nondisjunction)
    Q91.6Trisomy 13, translocation
    Q91.7Trisomy 13, unspecified

    DRG Codes

    1 rows

    DRG CodeDescription
    884Organic Disturbances and Intellectual Disability

    Typical Clinical Scenarios

    • A newborn in the neonatal intensive care unit with growth restriction, micrognathia, low-set ears, clenched hands with overlapping fingers, severe hypotonia, and multiple congenital heart defects identified on echocardiogram is evaluated after prenatal ultrasound suggested a chromosomal anomaly. Genetic testing (karyotype or chromosomal microarray) confirms full trisomy 18, explaining the constellation of congenital malformations and guiding prognosis and supportive care decisions. Typical codes: Q91.3, Q91.5
    • A term infant delivered after prenatal diagnosis of a chromosome 13 trisomy shows midline defects including holoprosencephaly on head imaging, polydactyly, cleft lip/palate, and severe feeding difficulties requiring nasogastric support; the family presents for neonatal palliative care consultation and coordination of outpatient genetics follow-up. The diagnosis of trisomy 13 accounts for the structural brain and facial anomalies and informs goals-of-care discussions and long-term planning. Typical codes: Q91.1, Q91.4
    • An adult patient with a known mosaic form of a trisomy identified in childhood presents to a genetics clinic for assessment of developmental delay, endocrine abnormalities, and fertility counseling; prior records document partial trisomic cell lines and a history of congenital cardiac repair. A code from this group is assigned to capture the chromosomal abnormality as a chronic comorbidity influencing surveillance and management of multisystem issues. Typical codes: Q91.6, Q91.7

    Related Codes

    Q90-DOWN-SYNDROME

    ICD-10-CM Code For Down Syndrome: Group Overview

    Q92-OTHER-TRISOMIES-AND-PARTIAL-TRISOMIES

    ICD-10-CM Code For Other Trisomies And Partial Trisomies Of The Autosomes Not Elsewhere Classified: Group Overview

    Q93-MONOSOMIES-AND-DELETIONS

    ICD-10-CM Code For Monosomies And Deletions From The Autosomes Not Elsewhere Classified: Group Overview

    Q95-BALANCED-REARRANGEMENTS-AND-STRUCTURAL-MARKERS

    ICD-10-CM Code For Balanced Rearrangements And Structural Markers Not Elsewhere Classified: Group Overview

    Q96-TURNERS-SYNDROME

    ICD-10-CM Code For Turner's Syndrome: Group Overview

    Q97-OTHER-SEX-CHROMOSOME-ABNORMALITIES-FEMALE-PHENOTYPE

    ICD-10-CM Code For Other Sex Chromosome Abnormalities Female Phenotype Not Elsewhere Classified: Group Overview

    Q98-OTHER-SEX-CHROMOSOME-ABNORMALITIES-MALE-PHENOTYPE

    ICD-10-CM Code For Other Sex Chromosome Abnormalities Male Phenotype Not Elsewhere Classified: Group Overview

    Q99-OTHER-CHROMOSOME-ABNORMALITIES-NOT-ELSEWHERE-CLASSIFIED

    ICD-10-CM Code For Other Chromosome Abnormalities, Not Elsewhere Classified: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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