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    OpenPayerBilling CodesUrticaria and erythemaICD-10-CM l51-erythema-multiforme
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    ICD-10-CM Code For Erythema Multiforme: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group L51 includes diagnoses for erythema multiforme ranging from minor cutaneous forms to more extensive presentations with mucosal involvement, including cases related to medications or infections. These ICD-10-CM diagnosis codes are used to document clinical scenarios such as acute targetoid skin eruptions, involvement of mucous membranes, or progression to more severe forms requiring additional medical management. Accurate coding within the ICD-10-CM L51 group supports proper claim adjudication.

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    ICD-10-CM L51: Erythema Multiforme Overview

    The ICD-10-CM L51 group represents erythema multiforme, an acute immune-mediated skin condition characterized by targetoid lesions and sometimes mucosal involvement. These diagnoses affect the integumentary system and can vary from localized cutaneous eruptions to more extensive disease with mucous membrane involvement. Accurate coding matters for reimbursement because it captures disease severity, documents complications, and supports appropriate claim adjudication.

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    When to Use

    Use a code from this group when a patient presents with clinical findings consistent with erythema multiforme, such as characteristic targetoid lesions or documented mucosal lesions. Select the code that reflects the extent of skin and mucosal involvement and any specified cause when documented, such as drug-induced or infection-associated cases.

    ICD-10-CM Codes

    6 rows

    ICD-10-CM CodeDescription
    L51.0Nonbullous erythema multiforme
    L51.1Stevens-Johnson syndrome
    L51.2Toxic epidermal necrolysis [Lyell]
    L51.3Stevens-Johnson syndrome-toxic epidermal necrolysis overlap syndrome
    L51.8Other erythema multiforme
    L51.9Erythema multiforme, unspecified

    DRG Codes

    2 rows

    DRG CodeDescription
    595Major Skin Disorders with MCC
    596Major Skin Disorders without MCC

    Typical Clinical Scenarios

    • An adult presents to the emergency department with a sudden onset of targetoid macules and bullous lesions on the extremities and trunk after a recent herpes simplex virus outbreak; mucous membranes are minimally involved and there is no systemic organ dysfunction. The acute, self-limited eruption follows an identifiable trigger and the clinician documents erythema multiforme major vs minor based on extent and mucosal involvement, prompting assignment of a diagnosis code from this group. Typical codes: L51.0, L51.1
    • A pediatric patient visits dermatology for recurrent, localized target lesions that develop over weeks after repeated medication exposures or infections; lesions are limited to the distal extremities with no mucosal involvement and symptoms have recurred over several months. Because this represents a recurrent, non-life-threatening form of erythema multiforme managed as an ongoing dermatologic condition, a code denoting erythema multiforme without significant mucous membrane involvement is used. Typical codes: L51.2, L51.9
    • A hospitalized patient on a new anticonvulsant develops widespread blistering, painful mucocutaneous erosions with systemic symptoms prompting concern for a severe mucocutaneous reaction; dermatology documents extensive mucosal involvement and epidermal necrolysis spectrum features requiring inpatient management. Given the severe mucosal-dominant presentation and need to distinguish from other bullous disorders, a specific code for erythema multiforme with significant mucous membrane involvement or specified severe form is assigned. Typical codes: L51.1, L51.3

    Related Codes

    L49-EXFOLIATION-DUE-TO-ERYTHEMATOUS-CONDITIONS

    ICD-10-CM Code For Exfoliation Due To Erythematous Conditions: Group Overview

    L50-URTICARIA

    ICD-10-CM Code For Urticaria: Group Overview

    L52-ERYTHEMA-NODOSUM

    ICD-10-CM Code For Erythema Nodosum: Group Overview

    L53-OTHER-ERYTHEMATOUS-CONDITIONS

    ICD-10-CM Code For Other Erythematous Conditions: Group Overview

    L54-ERYTHEMA-IN-DISEASES-CLASSIFIED-ELSEWHERE

    ICD-10-CM Code For Erythema In Diseases Classified Elsewhere: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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