HCPCS Level II code S9365 represents a per diem payment for home infusion therapy delivering total parenteral nutrition (TPN) at a one-liter-per-day regimen. The code covers administrative and professional pharmacy services, care coordination, and necessary supplies and equipment, while excluding nursing visits and nonstandard drugs that must be billed separately. This code matters nationally as home-based TPN supports patients with chronic intestinal failure or other conditions requiring long-term parenteral nutrition, shifting care from inpatient settings to home and affecting utilization, care coordination, and pharmacy workflows.

Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will learn which services are bundled under the per diem, how the code is typically used in home-infusion programs, and common billing considerations tied to supplies and pharmacy professional services. The publication provides national benchmarks and policy context related to home infusion coverage and reimbursement, clarifies reporting boundaries (what is included vs billed separately), and outlines implications for clinical and administrative teams responsible for home TPN delivery and billing. Data not available in the input is noted where applicable.