HCPCS Level II code S5520 denotes the bundled supplies required for insertion of a peripherally inserted central venous catheter (PICC) as part of home infusion therapy. This code identifies the complete supply set — including the catheter — furnished to enable PICC placement outside the acute care setting, supporting outpatient and home-based infusion care. Nationally, appropriate use of this HCPCS code matters for care continuity, outpatient infusion program operations, and accurate supply reimbursement for home infusion providers.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the code's clinical context and service setting, common modifiers and payer practices where available, and guidance on the types of benchmarks and policy updates typically reviewed for HCPCS supply codes in home infusion. The publication clarifies what the code covers, the expected site of service, and where to look for payer-specific guidance. Data not available in the input is noted where relevant.