HCPCS Level II code S5498 designates per diem home infusion therapy services for simple single-lumen catheter care and maintenance, including administrative and professional pharmacy services, care coordination, and all necessary supplies and equipment; drugs and nursing visits are billed separately. This code matters nationally as home infusion services expand, affecting care coordination, pharmacy administration practices, and payment workflows across commercial insurers and Medicare. Key payers included in this overview are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

Readers will find a concise explanation of what S5498 represents, typical sites of service, and the operational scope of per diem catheter maintenance in home infusion programs. The publication summarizes how major payers handle this service line, outlines common modifiers used with home infusion per diem claims, and presents benchmarking context where available. It also highlights clinical and billing considerations relevant to infusion pharmacies, home health agencies, and billing teams, including separation of drug and nursing visit coding. Data not available in the input for associated taxonomies, specific ICD-10 diagnoses, and related codes is noted where applicable.