HCPCS Level II code S5497 represents a per diem service for home infusion catheter care and maintenance that bundles administrative tasks, professional pharmacy services, care coordination, and supplies and equipment (excluding drugs and nursing visits). This code matters nationally as home infusion expands as an alternative to facility-based care, affecting payers, providers, and patients through care coordination and supply management needs. Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise briefing on what S5497 covers clinically and operationally, typical sites of service, and which major payers recognize or reimburse the service. The publication also outlines benchmarking context where available, common modifier usage, and implementation considerations relevant to billing workflows and revenue cycle processes. Policy updates and billing guidance summaries are provided at a national level to inform provider billing practice and payer contract discussions. Data not available in the input is noted where applicable.