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    v1.0.28
    OpenPayerBilling CodesTemporary National Codes (Non-Medicare)HCPCS hcpcs-s2411-fetoscopic-laser-therapy-twin-to-twin-transfusion-syndrome
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    HCPCS Level II S2411: Fetoscopic Laser Therapy for Twin-to-Twin Transfusion Syndrome

    HCPCS Level II code S2411 describes fetoscopic laser therapy for treatment of twin-to-twin transfusion syndrome, a minimally invasive fetal surgical procedure typically performed by maternal-fetal medicine or fetal surgery teams as an operative fetoscopy to coagulate placental vascular anastomoses; service type: therapeutic fetal intervention; typical site of service: hospital operating room or specialized fetal surgery center.

    For related coverage guidance, see recent payer policy updates: Fixed Wing Air Ambulance Transport, Air Ambulance, Ambulance Services (for Tennessee Only).

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    Table of contents

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    • Billing CodesCPT, HCPCS, DRG & more
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    • ModifiersCPT modifiers & usage
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    Clinical & Coding Specifications

    Clinical Context

    A 28-year-old gravida 2 para 1 woman with monochorionic diamniotic twin pregnancy at 19 weeks gestation presents after routine ultrasound demonstrates discordant fetal bladder sizes, oligohydramnios in one twin and polyhydramnios in the co-twin. Doppler studies suggest twin-to-twin transfusion syndrome (TTTS) Stage II progressing toward Stage III with abnormal ductus venosus flow in the donor twin. After multidisciplinary consultation with maternal-fetal medicine, neonatology, and anesthesiology, the patient is scheduled for fetoscopic laser photocoagulation of placental vascular anastomoses.

    Typical clinical workflow:

    • Pre-procedure counseling and informed consent with maternal-fetal medicine and neonatology.

    • Preoperative maternal testing: CBC, blood type and screen, infectious disease screening as indicated, and fetal ultrasound mapping of placental vascular connections.

    • Procedural day: regional or general anesthesia administered; continuous fetal monitoring when feasible; ultrasound-guided placement of a 3–4 mm fetoscope transabdominally into the recipient sac.

    • Fetoscopic inspection of the placental vascular equator and sequential laser coagulation of identified arterio-venous anastomoses until separation is achieved (selective or Solomon technique as indicated).

    • Hemostasis verification, removal of instruments, and monitoring for uterine contractions or membrane rupture.

    • Post-procedure monitoring in a maternal-fetal unit with repeat ultrasound within 24–72 hours and scheduled surveillance until delivery.

    Typical site of service: hospital operating room or procedure suite with maternal-fetal surgery capabilities; may occur in tertiary-care centers with fetal surgery programs.

    Typical patient scenario: a mid-trimester monochorionic diamniotic twin gestation complicated by progressive TTTS, where fetoscopic laser therapy is indicated to interrupt placental vascular anastomoses to improve survival and reduce neurologic morbidity in surviving twin(s).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    59076Fetal monitoring during labor and delivery (complicated) — Intrauterine fetal monitoring (non-specific for fetoscopy)May be used for intraoperative or immediate postoperative fetal monitoring documentation when separately reportable.
    76940Ultrasound guidance for procedures (e.g., needle placement)Used for ultrasound guidance during transabdominal fetoscopic access and mapping of placental vessels.
    59425Antepartum care only; delivery not included (high-risk)May apply to separate high-risk antepartum management encounters by the maternal-fetal medicine physician surrounding the fetal procedure.
    58353Removal of cervical cerclage (during pregnancy)Occasionally reported if cerclage removal is performed in the same episode when indicated prior to fetoscopic access.

    Related Modifiers

    14 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    32Modifier 32 (Mandated Services) indicates that a CPT-coded service was required by a third party—such as an insurer, school, state agency, or court. The AMA defines it as denoting services mandated…- Use Modifier 32 when a service or procedure was explicitly mandated by a third party (for example an insurer requiring a second opinion, a school requiring a sports physical, a state agency or…
    47Modifier -47 (“Anesthesia by Surgeon”) is appended to a surgical or procedural CPT code when the surgeon personally provides regional or general anesthesia for the procedure. Use of -47 indicates the…- Use modifier -47 when the surgeon personally provides regional or general anesthesia during the surgical procedure (i.e., the surgeon administers the anesthesia in addition to performing the…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…

    Showing 1–10 of 14

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    2080P0207XPediatric Hematology & Oncology PhysicianA pediatrician trained in the combination of pediatrics, hematology and oncology to recognize and manage pediatric blood disorders and cancerous disea…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    261QM0850XAdult Mental Health Clinic/CenterAn entity, facility, or distinct part of a facility providing diagnostic, treatment, and prescriptive services related to mental and behavioral disord…
    207ZP0105XClinical Pathology/Laboratory Medicine PhysicianA pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis and treatment through knowledge gained by the labora…
    246ZN0300XNephrology Specialist/TechnologistTechnologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Other
    163WX0002XHigh-Risk Obstetric Registered NurseNursing Service Providers · Registered Nurse

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    9 rows

    PolicyPayerEffective Date
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01
    Ambulance Services (for Tennessee Only)UnitedHealthcare2026-08-01
    Ambulance Services (for New Mexico Only)UnitedHealthcare2026-08-01
    Clinical Policy: Air AmbulanceArizona Complete Health2026-08-01
    Clinical Policy: Air AmbulanceCentene2026-08-01
    Air AmbulanceCentene2026-08-01
    Clinical Policy: Air AmbulanceAmbetter Nevada2026-08-01
    Ambulance TransportProvidence Health Plan2026-07-01

    Related Codes

    HCPCS-LEVEL-II-S2152-SOLID-ORGAN-TRANSPLANTATION-GLOBAL-CARE

    HCPCS Level II S2152: Solid Organ Procurement and Transplantation

    HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

    HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

    HCPCS-LEVEL-II-S3630-EOSINOPHIL-COUNT-BLOOD-DIRECT

    HCPCS Level II S3630: Eosinophil Count, Blood, Direct

    HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

    HCPCS Level II S4017: Incomplete Cycle — Cancelled Prior to Stimulation

    HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

    HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction

    HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

    HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

    HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

    HCPCS Level II S9024: Paranasal Sinus Ultrasound

    HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

    HCPCS Level II S9366: Home Infusion TPN, 1–2 L/day

    HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

    HCPCS S9446: Patient Education, Non-Physician Provider, Group, Per Session

    HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

    HCPCS S9451: Exercise Classes, Non-Physician Provider, Per Session

    Showing 1–10 of 532

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    76937Ultrasound guidance for vascular access (e.g., needle/catheter placement, real-time)Used when real-time ultrasound guidance is billed for instrument placement into an amniotic sac.